U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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ANABASINE

MORE DETAILS

  LMS11II2LO

Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Cytochrome P450 19A1
39
Neuronal acetylcholine receptor protein alpha-7 subunit
77
Cytochrome P450 19A1
39
Neuronal acetylcholine receptor protein alpha-7 subunit
77
Conditions:
Nicotine dependence
32
Schizophrenia
298
Anabasine, a tobacco alkaloid, was used as a biomarker of active tobacco use. Anabasine is a selective alpha7-nicotinic acetylcholine receptor agonist. Anabasine antagonized MK-801-elicited mouse popping behavior, an animal model of schizophrenia.
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National Center for Advancing Translational Sciences (NCATS),
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