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Restrict the search for
phenyl aminosalicylate
to a specific field?
Status:
Investigational
Source:
INN:piridicillin [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Piridicillin is the semi-synthetic penicillin. It has exhibited broad-spectrum activity in vitro against gram-positive cocci, except penicillin G-resistant Staphylococcus aureus, and against gram-negative bacilli. Piridicillin is reported to be more active in-vitro than piperacillin, azlocillin or ticarcillin against Ps. aeruginosa. It is unstable at alkaline pH and displays marked inoculum independence.
Status:
Investigational
Source:
NCT04009044: Phase 2 Interventional Recruiting Cancer Survivor
(2020)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Hydroxytamoxifen (Afimoxifene) is an active metabolite of tamoxifen exerting estrogen receptor modulatory function. In addition, hydroxytamoxifen binds to regulates transcriptional activity of the estrogen-related receptor gamma. ASCEND Therapeutics, Inc. was developing TamoGel (4-hydroxytamoxifen gel) for a variety of estrogen-dependent conditions, including breast cancer, cyclic breast pain and gynecomastia.
Class (Stereo):
CHEMICAL (ACHIRAL)
Motrazepam (Ro06-9098) is a benzodiazepine derivative patented by a Swiss multinational healthcare company Hoffmann-La Roche as anticonvulsants, muscle relaxants, and sedative agent.
Class (Stereo):
CHEMICAL (ABSOLUTE)
ROTAMICILLIN was developed as an antibiotic that has never been marketed.
Class (Stereo):
CHEMICAL (ACHIRAL)
Asulacrine, also known as CI-921, an inhibitor of topoisomerase II, participated in clinical trials phase II for the treatment of cancer. In spite of the positive and promising results, this drug showed the toxicity, phlebitis that blocks its implementation in the future.
Status:
Investigational
Source:
NCT00541567: Phase 2/Phase 3 Interventional Withdrawn Obesity and Type 2 Diabetes
(2008)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Ibipinabant (IBI) is an orally active potent cannabinoid-1 receptor (CB1R) antagonist. This drug was studied for the treatment of obesity and psychotic disorders. However, the development of the drug was discontinued in November 2008. Now, ibipinabant is only used for laboratory research, especially structure-activity relationship studies into novel CB1 antagonists.
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Piperamide is substituted piperazine with a tertiary amine group. It was used as an anthelmintic agent. Initially, it was investigated because of its effectiveness against Trypanosoma. Piperamide distorts choroid plexus epithelial ultrastructure by engendering hydropic vacuoles.
Class (Stereo):
CHEMICAL (RACEMIC)
Targets:
Clocinizine is an antihistamine derivative of diphenylmethylpiperazine. Clocinizine is a competitive and reversible H1 receptor antagonist. The drug is marketed in Spain under tradename Senioral in combination with phenylpropanolamine for temporary relief of nasal congestion in colds, rhinitis, and sinusitis.
Class (Stereo):
CHEMICAL (ACHIRAL)
Lexofenac is an ibufenac derivative. It was developed as anti-inflammatory and analgesic agent.
Status:
Investigational
Source:
NCT00040989: Phase 2 Interventional Withdrawn Stage IV Renal Cell Cancer
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Afeletecan (Bay 38-3441) is a camptothecin glycoconjugate which stabilizes the active lactone form of camptothecin and allows selective uptake into tumor cells. Afeletecan is a topoisomerase inhibitor. Afeletecan was in phase I clinical trials with Bayer for the treatment of cancer; however, development appears to have been discontinued.
