PIPERAMIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H28N4O
Molecular Weight	304.4304
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)CCCN1CCN(CC1)C2=CC=C(NC(C)=O)C=C2

InChI

InChIKey=DPCSPGOPQYRPCP-UHFFFAOYSA-N

InChI=1S/C17H28N4O/c1-15(22)18-16-5-7-17(8-6-16)21-13-11-20(12-14-21)10-4-9-19(2)3/h5-8H,4,9-14H2,1-3H3,(H,18,22)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4970351 | https://www.ncbi.nlm.nih.gov/pubmed/21189316 | Spencer, P.S., Schaumburg, H.H. (1980) Experimental and Clinical Neurotoxicology, page 604, retrieved from: https://books.google.ru/books?id=RL9rAAAAMAAJ | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 987, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Piperamide is substituted piperazine with a tertiary amine group. It was used as an anthelmintic agent. Initially, it was investigated because of its effectiveness against Trypanosoma. Piperamide distorts choroid plexus epithelial ultrastructure by engendering hydropic vacuoles.

Approval Year

PubMed

Title	Date	PubMed
Piperamide-induced morphological changes in the choroid plexus.	1968 Aug	4970351
Impact of novel N-aryl piperamide NO donors on NF-κB translocation in neuroinflammation: rational drug-designing synthesis and biological evaluation.	2018 Jan	29145791

Name

Type

Language

PIPERAMIDE

Official Name

English

ACETAMIDE, N-(4-(4-(3-(DIMETHYLAMINO)PROPYL)-1-PIPERAZINYL)PHENYL)-

Systematic Name

English

piperamide [INN]

Common Name

English

4'-(4-(3-(DIMETHYLAMINO)PROPYL)-1-PIPERAZINYL)ACETANILIDE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C250