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Search results for ethanolamine root_notes_note in Note (approximate match)
Status:
US Previously Marketed
Source:
21 CFR 310.545(a)(18)(v)(A) skin protectant:insect bites/stings trolamine
Source URL:
First approved in 1952
Source:
NDA007936
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Trolamine, an organic compound, is the salt formed between triethanolamine and salicylic acid. It is widely used as a topical analgesic. 10% trolamine salicylate medical products sold over-the-counter such as are creams for temporarily relief of minor aches and pains of muscles and joints associated with arthritis, simple backache, lumbago, neuralgia, strains, bruises, and sprains. The FDA approved in 1958 otic solution drops containing triethanolamine polypeptide used in the ear to break down and loosen earwax was discontinued. Trolamine can enhance skin healing by recruiting macrophages and modifying the concentrations of various immunomodulators. Trolamine (Biafine; Genmedix Ltd, France) is commonly prescribed at the beginning of radiotherapy for preventing acute radiation-induced skin toxicity in China. Biafine has been studied in radiodermatitis and Phase 2 clinical trial has been initiated in 2016 by Sun Yat-sen University to establish the efficacy of trolamine (Biafine) for the management of radiation dermatitis in patients with nasopharyngeal carcinoma receiving IMRT.
Status:
US Previously Marketed
Source:
Oleic Acid U.S.P.
(1921)
Source URL:
First marketed in 1921
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Oleic acid is an unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. Oleic acid occurs naturally in various animal and vegetable fats and oils. It is a component of the normal human diet as a part of animal fats and vegetable oils. Oleic acid may be responsible for the hypotensive (blood pressure reducing) effects of olive oil. Oleic acid has being shown to have a potential anticancer activity.
Status:
US Previously Marketed
Source:
Corrosive Mercuric Chloride U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Corrosive Mercuric Chloride U.S.P.
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Potassium Triiodomercurate(II) is a periodometallate salt. It contains a triiodomercurate(1-). It is an antiseptic (topical) and disinfectant. It is also an antiseborrheic agent.
Status:
US Previously Marketed
First marketed in 1921
Class (Stereo):
CHEMICAL (ACHIRAL)
Mercury, with the chemical symbol Hg (from Greek "Hydrargyros"), is the only metal adopting liquid form in room temperature. Mercury appears in seven natural isotopic forms. The metal is extracted from the mineral cinnabar, mercuric sulfide, in former times used also for paint. Mercury has fascinated people for millennia, as a heavy liquid metal. However, because of its toxicity, many uses of mercury are being phased out or are under review. It is now mainly used in the chemical industry as catalysts. It is also used in some electrical switches and rectifiers. Previously its major use was in the manufacture of sodium hydroxide and chlorine by electrolysis of brine. These plants will all be phased out by 2020. Elemental mercury is used in thermometers, blood pressure devices, and thermostats because its ability to expand and contract uniformly makes it useful for measuring changes in temperature and pressure. Mercury is also used in dental fillings, paints, soaps, batteries, and fluorescent lighting. Mercury will dissolve numerous metals to form amalgams and is used to extract gold dust from rocks by dissolving the gold and then boiling off the mercury. The amalgam used in dental fillings contains tin and silver alloyed with mercury. Because it works as a biocide, mercury has been used as a fungicide in paint, though this kind of paint is no longer sold. Mercury and its compounds used in dental practice may be responsible for release of mercury into the oral cavity. Compounds of mercury tend to be much more toxic than the element itself, and organic compounds of mercury (e.g., dimethyl-mercury) are often extremely toxic and may be responsible in causing brain and liver damage. Human exposure to mercury has increased through anthropogenic mercury emissions from fuel combustion, municipal incinerators, and chemical industries. Mercury is considered a major environmental toxicant throughout the world. Mercury is harmless in insoluble form, but vapor or soluble forms such as inorganic mercury or methylmercury can be extremely toxic to humans. Most human mercury exposure occurs through inhalation of elemental mercury vapor released from dental amalgam and through the consumption of fish contaminated with methylmercury.
Status:
US Previously Marketed
Source:
THEOMINAL RS THEOBROMINE by WINTHROP
(1961)
Source URL:
First marketed in 1921
Source:
Theobromine Sodio-Salicylate U.S.P.
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Theobromine is the primary alkaloid present in the cocoa and chocolate. Theobromine is found in the shells and beans of the cacao plant and it is extracted from the husks of the bean and used for the synthesis of caffeine. Theobromine is an adenosine A1 and A2a receptor antagonist. Thesodate is used as a vasodilator, a diuretic, and heart stimulant. And similar to caffeine, it may be useful in management of fatigue and orthostatic hypotension. The symptomatic adverse reactions produced by theobromine are more or less tolerable and if they become severe, they can be treated symptomatically, these include anxiety, restlessness, tremors, sleeplessness, nausea and vomiting, loss of appetite. Theobromine is currently not in use as a medicinal drug.
Status:
US Previously Marketed
Source:
21 CFR 310.545(a)(7) dandruff mercury oleate
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Mercury oleate is a yellowish to red liquid/semi-solid or solid mass. Prepared by dissolving yellow mercuric oxide in oleic acid. Contains 24-26% HgO by mass. Insoluble in water. Toxic by ingestion. Used in medicine, antiseptic and antifouling paint. Mercury oleate was once used to treat ordinary ringworm (tinea circinata).
Status:
Possibly Marketed Outside US
Source:
M016
(2024)
Source URL:
First approved in 2024
Source:
M016
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
Possibly Marketed Outside US
Source:
505G(a)(3)
(2023)
Source URL:
First approved in 2023
Source:
505G(a)(3)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)