U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 101 - 110 of 2582 results

Status:
Investigational
Source:
USAN:Acebrochol
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Acebrochol is a neuroactive steroid that may act as a sedative and hypnotic, through the mechanism of altering ligand-gated ion channels and cell surface receptors.
Status:
Investigational
Source:
INN:rifamexil
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Rifamexil (also known as MDL 62769 or P/DEA) is a derivative of rifamycin (a natural antibiotic produced by Amycolatopsis rifamycinica). This drug has greater intrinsic activity against Myobacterium avium (MAC) than rifampin. Information on current use of this compound is not available.
Status:
Investigational
Source:
INN:nisbuterol
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Nisbuterol, a nicotinic acid ester, is a bronchodilator.
Status:
Investigational
Source:
INN:salmisteine
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Salmisteine was studied as an antipyretic and mucolytic agent. Information about the current use of this compound is not available.
Status:
Investigational
Source:
INN:oxabrexine
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Oxabrexine was developed as a diuretic; however, this compound has never been marketed. Information about the current use of this compound is not available.
Status:
Investigational
Source:
INN:clentiazem
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Clentiazem is a chloride derivative of diltiazem, originated in Tanabe Seiyaku. It works as a blocker of calcium channels. The drug was investigated in the clinical trials for the treatment of stable angina, and essential hypertension. Despite the positive results of clinical trials, no development of the drug was reported.
Status:
Investigational
Source:
INN:pyrrolifene [INN]
Source URL:

Class (Stereo):
CHEMICAL (UNKNOWN)

Pyrroliphene is a dialkylaminodiphenylbutanol ester with antitussive and analgesic activities. In clinical trials the major side effect of Pyrroliphene was sedation, and the other side effect liabilities were similar to those of morphine.
Status:
Investigational
Source:
INN:cicortonide
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Cicortonide is a synthetic cyano-glucocorticoid with anti-inflammatory and antirheumatic, as well as antiallergenic properties.
Status:
Investigational
Source:
INN:mespirenone
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Mespirenone (ZK 94679, 15β,16β-methylene-spironolactone) is a steroid aldosterone antagonist. In addition, it is a quite specific inhibitor of adrenocortical mineralocorticoid synthesis. In rodents mespirenone effectively prevents aldosterone-induced hypertension. It exerts natriuretic efficacy. Although it reached phase II clinical trials, it was discontinued in 1989.
Status:
Investigational
Source:
INN:diacetamate [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Diacetamate (Acetaminophen Acetate, Acetaminophen Impurity, diacetyl-p-aminophenol) is a acetaminophen synthetic impurity. Acetaminophen-aspirin mixtures have lower stability due to acetylation of the former by the latter, producing diacetyl-p-aminophenol.