Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C22H25ClN2O4S |
| Molecular Weight | 448.963 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC=C(C=C1)[C@@H]2SC3=C(C=CC(Cl)=C3)N(CCN(C)C)C(=O)[C@@H]2OC(C)=O
InChI
InChIKey=GYKFWCDBQAFCLJ-RTWAWAEBSA-N
InChI=1S/C22H25ClN2O4S/c1-14(26)29-20-21(15-5-8-17(28-4)9-6-15)30-19-13-16(23)7-10-18(19)25(22(20)27)12-11-24(2)3/h5-10,13,20-21H,11-12H2,1-4H3/t20-,21+/m1/s1
Clentiazem is a chloride derivative of diltiazem, originated in Tanabe Seiyaku. It works as a blocker of calcium channels. The drug was investigated in the clinical trials for the treatment of stable angina, and essential hypertension. Despite the positive results of clinical trials, no development of the drug was reported.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Protective effects of the calcium antagonists diltiazem and TA3090 against hepatic injury due to hypoxia. | 1992 Dec 1 |
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| Protective effect of clentiazem against epinephrine-induced cardiac injury in rats. | 1993 Jul |
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| Sex-related differences in the renal disposition of the acidic metabolite of clentiazem in rat. | 2001 Oct |
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| Effects of first and second generation calcium channel blockers on diastolic function of the failing hamster heart: relationship with coronary flow changes. | 2003 Jul |
|
| 1,5-Benzothiazepine, a versatile pharmacophore: a review. | 2008 Nov |
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NCI_THESAURUS |
C333
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96125-53-0
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CLENTIAZEM
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SUB06653MIG
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100000080214
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CHEMBL165667
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DTXSID901028074
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40DK034DRC
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m3616
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6453
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C056595
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C81679
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57026
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
