CLENTIAZEM

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H25ClN2O4S
Molecular Weight	448.963
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(C=C1)[C@@H]2SC3=C(C=CC(Cl)=C3)N(CCN(C)C)C(=O)[C@@H]2OC(C)=O

InChI

InChIKey=GYKFWCDBQAFCLJ-RTWAWAEBSA-N

InChI=1S/C22H25ClN2O4S/c1-14(26)29-20-21(15-5-8-17(28-4)9-6-15)30-19-13-16(23)7-10-18(19)25(22(20)27)12-11-24(2)3/h5-10,13,20-21H,11-12H2,1-4H3/t20-,21+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C22H25ClN2O4S
Molecular Weight	448.963
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1642678 | https://adisinsight.springer.com/drugs/800000188 | https://www.ncbi.nlm.nih.gov/pubmed/8450166

Clentiazem is a chloride derivative of diltiazem, originated in Tanabe Seiyaku. It works as a blocker of calcium channels. The drug was investigated in the clinical trials for the treatment of stable angina, and essential hypertension. Despite the positive results of clinical trials, no development of the drug was reported.

Approval Year

PubMed

Title	Date	PubMed
Protective effects of the calcium antagonists diltiazem and TA3090 against hepatic injury due to hypoxia.	1992 Dec 1	1472086
Protective effect of clentiazem against epinephrine-induced cardiac injury in rats.	1993 Jul	8392553
Sex-related differences in the renal disposition of the acidic metabolite of clentiazem in rat.	2001 Oct	11695851
Effects of first and second generation calcium channel blockers on diastolic function of the failing hamster heart: relationship with coronary flow changes.	2003 Jul	12827040
1,5-Benzothiazepine, a versatile pharmacophore: a review.	2008 Nov	18639369

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:13:39 GMT 2023` Edited by `admin` on `Fri Dec 15 16:13:39 GMT 2023`
Record UNII	40DK034DRC
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CLENTIAZEM

Official Name

English

clentiazem [INN]

Common Name

English

Clentiazem [WHO-DD]

Common Name

English

CLENTIAZEM [MI]

Common Name

English

(+)-(2S,3S)-8-CHLORO-5-(2-(DIMETHYLAMINO)ETHYL)-2,3-DIHYDRO-3-HYDROXY-2-(P-METHOXYPHENYL)-1,5-BENZOTHIAZEPIN-4(5H)-ONE ACETATE (ESTER)

Common Name

English

1,5-BENZOTHIAZEPIN-4(5H)-ONE, 3-(ACETYLOXY)-8-CHLORO-5-(2-(DIMETHYLAMINO)ETHYL)-2,3-DIHYDRO-2-(4-METHOXYPHENYL)-, (2S-CIS)-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C333