U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

Showing 1061 - 1070 of 1227 results

Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Diisopropyl adipate, a skin's surface lubricant, is used to dissolve other substances in cosmetics and personal care products, for example, in LADYS CHOICE INVISIBLE SOLID ANTIPERSPIRANT DEODORANT CUCUMBER MELON. In addition, diisopropyl adipate is an inactive ingredient of JUBLIA (efinaconazole), which is used for topical treatment of onychomycosis of the toenail(s) due to Trichophyton rubrum and Trichophyton mentagrophytes.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Isopropyl Isostearate is the ester of Isopropyl Alcohol and Isostearic Acid used in beauty products as an emollient, skin conditioning agent, binder and humectant. Isopropyl Isostearate is ideal for heat sensitive personal care formulations. It enables superior odour and colour end-products. It also exhibits excellent skin feel without feel of greasiness.
Lorcainide is a class Ic antiarrhythmic medication. It was reported to be highly efficient for the treatment of ventricular arrhythmias, ventricular fibrillation, and tachycardia. The drug was used under the name Remivox. The mechanism of lorcainide action involves the blockage of sodium channels. Lorcainide was withdrawn from the market for a commercial reason, but later it was admitted that the use of the drug is associated with high risk of death.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (RACEMIC)

Iprazochrome is a serotonin antagonist both in vitro and in vivo. It is used in the prophylaxis of migraine and in the treatment of diabetic retinopathy.
Status:
Possibly Marketed Outside US
Source:
NCT03081052: Phase 4 Interventional Completed Heart Transplant Surgery
(2017)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Tezosentan (Veletri; Ro 61–0612) is a dual endothelin receptor antagonist that has been shown to improve cardiac output, decrease pulmonary capillary wedge pressure, and reduce pulmonary and systemic vascular resistance in initial clinical studies in acutely decompensated heart failure. Tezosentan is a water-soluble ET-1 receptor antagonist with high affinity to both ETA and ETB receptors but greater potency for the ETA receptor subtype. Clinical studies demonstrated mixed results for Tezosentan regarding its efficacy and tolerability in the management of decompensated heart failure. The side effects of Tezosentan include a headache, nausea, and hypotension.
Cambendazole is a veterinary anti-parasitic drug, which was approved by FDA for the treatment of worm infections in horses. The mode of action of cambendazole is the inhibition of glucose uptake, fumarate reductase and phosphoenolpyruvate carboxykinase. Due to its mechanism of action, cambendazole causes the paralysis of parasites.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ABSOLUTE)

Amesergide (previously known as LY237733) an ergoline derivative with highly selective 5-hydroxytryptamine (5-HT) antagonist activity and with a long duration of action. This drug was in phase II clinical trials for the treatment of erectile dysfunction and for the treatment of premature ejaculation. In addition, this drug participated in preclinical experiments to treat depression. All these studies were discontinued.
Status:
Possibly Marketed Outside US
Source:
Japan:Miproxifene Phosphate
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

TAT-59 (Miproxifene Phosphate) is a triphenylethylene analog of tamoxifen. TAT-59 is the phosphate ester prodrug of the practically insoluble parent drug DP-TAT-59. It is an antiestrogen developed in Japan for breast cancer. It is a potent antitumor agent for hormone-dependent tumors. Most of TAT-59 metabolites possessed remarkable binding affinity toward estrogenic receptors as well as fairly good antiuterotrophic activity.
Status:
Possibly Marketed Outside US
Source:
UK NHS:Moxisylyte hydrochloride
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Moxisylyte, also known as thymoxamine, is a drug used in urology for the treatment of erectile dysfunction, also was studied, that this drug may be useful to treat ocular disorders such as diabetic retinopathy. It is an alpha1-adrenergic antagonist. Was developed for self-injection therapy in France and marketed in several European countries as Icavex. In the spring 2005 the manufacturer of Icavex decided to withdraw this drug from Europe market, presumable due to its low market shares.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Propallylonal under brand name Nostal was used as a sedative and anticonvulsant agent.

Showing 1061 - 1070 of 1227 results