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Details

Stereochemistry ACHIRAL
Molecular Formula C16H25NO3
Molecular Weight 279.3746
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MOXISYLYTE

SMILES

CC(C)C1=CC(OC(C)=O)=C(C)C=C1OCCN(C)C

InChI

InChIKey=VRYMTAVOXVTQEF-UHFFFAOYSA-N
InChI=1S/C16H25NO3/c1-11(2)14-10-15(20-13(4)18)12(3)9-16(14)19-8-7-17(5)6/h9-11H,7-8H2,1-6H3

HIDE SMILES / InChI
Molecular Formula C16H25NO3
Molecular Weight 279.3746
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://books.google.ru/books?id=S4GJio79XOUC&pg=PA97&lpg=PA97&dq=MOXISYLYTE+%09Withdrawal&source=bl&ots=dzBbL_E8c0&sig=r1pfUZ1LhFGihzzNswfGr7f38Mg&hl=ru&sa=X&ved=0ahUKEwjNlJeazZnOAhWJnBoKHZRoC3YQ6AEIVzAJ#v=onepage&q=MOXISYLYTE%20%09Withdrawal&f=false http://www.ncbi.nlm.nih.gov/pubmed/1475074

Moxisylyte, also known as thymoxamine, is a drug used in urology for the treatment of erectile dysfunction, also was studied, that this drug may be useful to treat ocular disorders such as diabetic retinopathy. It is an alpha1-adrenergic antagonist. Was developed for self-injection therapy in France and marketed in several European countries as Icavex. In the spring 2005 the manufacturer of Icavex decided to withdraw this drug from Europe market, presumable due to its low market shares.

Originator

Approval Year

Unknown
134361
Targets

Targets

Primary TargetPharmacologyConditionPotency
Antagonist
2760
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Withdrawn
Unknown

Approved Use

Unknown
Primary
Preclinical
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Effect of thymoxamine and pilocarpine on the depth of the anterior chamber.
1980 Oct
Effects of thymoxamine and its metabolites on clonidine-induced hypotension and bradycardia in rats.
1982 Jul
Ergotamine-induced peripheral ischaemia reversed by oral thymoxamine hydrochloride.
1986 Jan
The esterase-like activity of serum albumin may be due to cholinesterase contamination.
2001 Oct
Synergistic effects of sildenafil on relaxation of rabbit and rat cavernosal smooth muscles when combined with various vasoactive agents.
2001 Oct
Assessment of the intrinsic urethral sphincter component function in postprostatectomy urinary incontinence.
2002
Unoprostone isopropyl ester darkens iris color in pigmented rabbits with sympathetic denervation.
2003 Aug
Oral vasodilators for primary Raynaud's phenomenon.
2008 Apr 16
Raynaud's phenomenon (primary).
2008 Dec 16
Raynaud's phenomenon (secondary).
2008 Sep 26
Patents

Patents

JPH0262846A
3
JPS5925357A
2

Sample Use Guides

In Vivo Use Guide
Intracavernous injection of moxisylyte at 10, 20 or 30 mg can induce an erection adequate for intercourse in most of the patients
Route of Administration: Other
In Vitro Use Guide
Moxisylyte hydrochloride on isolated human penile corpus cavernosum tissue was investigated and compared with other alpha-adrenergic antagonists. Moxisylyte produced a concentration-dependent relaxation of a norepinephrine-induced (1 x 10(-5) M) contraction of the corpus cavernosum tissue. Pretreatment with 1 x 10(-6) M doses of moxisylyte reduced competitively the norepinephrine-induced contraction
Substance Class Chemical
Created
by admin
on Wed Jul 05 22:40:07 UTC 2023
Edited
by admin
on Wed Jul 05 22:40:07 UTC 2023
Record UNII
PW8QYA7KI0
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MOXISYLYTE
INN   MI   WHO-DD  
INN  
Official Name English
MOXISYLYTE [MI]
Common Name English
CARLYTENE
Brand Name English
(2-(4-ACETOXY-2-ISOPROPYL-5-METHYLPHENOXY)ETHYL)DIMETHYLAMINE
Systematic Name English
6-ACETOXYTHYMOL 2-(DIMETHYLAMINO)ETHYL ETHER
Common Name English
THYMOXAMINE
Common Name English
Moxisylyte [WHO-DD]
Common Name English
moxisylyte [INN]
Common Name English
Classification Tree Code System Code
WHO-ATC G04BE06
Created by admin on Wed Jul 05 22:40:07 UTC 2023 , Edited by admin on Wed Jul 05 22:40:07 UTC 2023
NCI_THESAURUS C29713
Created by admin on Wed Jul 05 22:40:07 UTC 2023 , Edited by admin on Wed Jul 05 22:40:07 UTC 2023
WHO-VATC QC04AX10
Created by admin on Wed Jul 05 22:40:07 UTC 2023 , Edited by admin on Wed Jul 05 22:40:07 UTC 2023
WHO-VATC QG04BE06
Created by admin on Wed Jul 05 22:40:07 UTC 2023 , Edited by admin on Wed Jul 05 22:40:07 UTC 2023
WHO-ATC C04AX10
Created by admin on Wed Jul 05 22:40:07 UTC 2023 , Edited by admin on Wed Jul 05 22:40:07 UTC 2023
Code System Code Type Description
EVMPD
SUB09090MIG
Created by admin on Wed Jul 05 22:40:07 UTC 2023 , Edited by admin on Wed Jul 05 22:40:07 UTC 2023
PRIMARY
PUBCHEM
4260
Created by admin on Wed Jul 05 22:40:07 UTC 2023 , Edited by admin on Wed Jul 05 22:40:07 UTC 2023
PRIMARY
RXCUI
10561
Created by admin on Wed Jul 05 22:40:07 UTC 2023 , Edited by admin on Wed Jul 05 22:40:07 UTC 2023
PRIMARY RxNorm
FDA UNII
PW8QYA7KI0
Created by admin on Wed Jul 05 22:40:07 UTC 2023 , Edited by admin on Wed Jul 05 22:40:07 UTC 2023
PRIMARY
INN
1538
Created by admin on Wed Jul 05 22:40:07 UTC 2023 , Edited by admin on Wed Jul 05 22:40:07 UTC 2023
PRIMARY
SMS_ID
100000080620
Created by admin on Wed Jul 05 22:40:07 UTC 2023 , Edited by admin on Wed Jul 05 22:40:07 UTC 2023
PRIMARY
NCI_THESAURUS
C87584
Created by admin on Wed Jul 05 22:40:07 UTC 2023 , Edited by admin on Wed Jul 05 22:40:07 UTC 2023
PRIMARY
MESH
D013948
Created by admin on Wed Jul 05 22:40:07 UTC 2023 , Edited by admin on Wed Jul 05 22:40:07 UTC 2023
PRIMARY
MERCK INDEX
M7648
Created by admin on Wed Jul 05 22:40:07 UTC 2023 , Edited by admin on Wed Jul 05 22:40:07 UTC 2023
PRIMARY Merck Index
ECHA (EC/EINECS)
200-204-1
Created by admin on Wed Jul 05 22:40:07 UTC 2023 , Edited by admin on Wed Jul 05 22:40:07 UTC 2023
PRIMARY
ChEMBL
CHEMBL159226
Created by admin on Wed Jul 05 22:40:07 UTC 2023 , Edited by admin on Wed Jul 05 22:40:07 UTC 2023
PRIMARY
EPA CompTox
DTXSID4023339
Created by admin on Wed Jul 05 22:40:07 UTC 2023 , Edited by admin on Wed Jul 05 22:40:07 UTC 2023
PRIMARY
DRUG BANK
DB09205
Created by admin on Wed Jul 05 22:40:07 UTC 2023 , Edited by admin on Wed Jul 05 22:40:07 UTC 2023
PRIMARY
DRUG CENTRAL
1855
Created by admin on Wed Jul 05 22:40:07 UTC 2023 , Edited by admin on Wed Jul 05 22:40:07 UTC 2023
PRIMARY
CAS
54-32-0
Created by admin on Wed Jul 05 22:40:07 UTC 2023 , Edited by admin on Wed Jul 05 22:40:07 UTC 2023
PRIMARY
WIKIPEDIA
Moxisylyte
Created by admin on Wed Jul 05 22:40:07 UTC 2023 , Edited by admin on Wed Jul 05 22:40:07 UTC 2023
PRIMARY
Related Record Type Details
ALPHA-1A ADRENERGIC RECEPTOR
TARGET -> AGONIST
Structure of MOXISYLYTE HYDROCHLORIDE
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of MOXISYLYTE
ACTIVE MOIETY
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