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Details

Stereochemistry ACHIRAL
Molecular Formula C16H25NO3.ClH
Molecular Weight 315.836
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MOXISYLYTE HYDROCHLORIDE

SMILES

Cl.CC(C)C1=CC(OC(C)=O)=C(C)C=C1OCCN(C)C

InChI

InChIKey=IPWGSXZCDPTDEH-UHFFFAOYSA-N
InChI=1S/C16H25NO3.ClH/c1-11(2)14-10-15(20-13(4)18)12(3)9-16(14)19-8-7-17(5)6;/h9-11H,7-8H2,1-6H3;1H

HIDE SMILES / InChI
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C16H25NO3
Molecular Weight 279.3746
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://books.google.ru/books?id=S4GJio79XOUC&pg=PA97&lpg=PA97&dq=MOXISYLYTE+%09Withdrawal&source=bl&ots=dzBbL_E8c0&sig=r1pfUZ1LhFGihzzNswfGr7f38Mg&hl=ru&sa=X&ved=0ahUKEwjNlJeazZnOAhWJnBoKHZRoC3YQ6AEIVzAJ#v=onepage&q=MOXISYLYTE%20%09Withdrawal&f=false http://www.ncbi.nlm.nih.gov/pubmed/1475074

Moxisylyte, also known as thymoxamine, is a drug used in urology for the treatment of erectile dysfunction, also was studied, that this drug may be useful to treat ocular disorders such as diabetic retinopathy. It is an alpha1-adrenergic antagonist. Was developed for self-injection therapy in France and marketed in several European countries as Icavex. In the spring 2005 the manufacturer of Icavex decided to withdraw this drug from Europe market, presumable due to its low market shares.

Originator

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Antagonist
2778
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Withdrawn
Unknown

Approved Use

Unknown
Primary
Preclinical
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Effect of thymoxamine and pilocarpine on the depth of the anterior chamber.
1980 Oct
Effects of thymoxamine and its metabolites on clonidine-induced hypotension and bradycardia in rats.
1982 Jul
[Intracavernous injections in the treatment of erectile dysfunction in spinal cord injured patients: experience with 36 patients].
2001 Feb
The esterase-like activity of serum albumin may be due to cholinesterase contamination.
2001 Oct
Synergistic effects of sildenafil on relaxation of rabbit and rat cavernosal smooth muscles when combined with various vasoactive agents.
2001 Oct
Assessment of the intrinsic urethral sphincter component function in postprostatectomy urinary incontinence.
2002
Alpha(1L)-, but not alpha(1H)-, adrenoceptor antagonist prevents allergic bronchoconstriction in guinea pigs in vivo.
2002 Sep 27
Electroacupuncture-induced pressor and chronotropic effects in anesthetized rats.
2006 Jan 30
Patents

Patents

JPH0262846A
3
JPS5925357A
2

Sample Use Guides

In Vivo Use Guide
Intracavernous injection of moxisylyte at 10, 20 or 30 mg can induce an erection adequate for intercourse in most of the patients
Route of Administration: Other
In Vitro Use Guide
Moxisylyte hydrochloride on isolated human penile corpus cavernosum tissue was investigated and compared with other alpha-adrenergic antagonists. Moxisylyte produced a concentration-dependent relaxation of a norepinephrine-induced (1 x 10(-5) M) contraction of the corpus cavernosum tissue. Pretreatment with 1 x 10(-6) M doses of moxisylyte reduced competitively the norepinephrine-induced contraction
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:09:01 GMT 2023
Edited
by admin
on Fri Dec 15 15:09:01 GMT 2023
Record UNII
WK2KZM9V6X
Record Status Validated (UNII)
Record Version
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Name Type Language
MOXISYLYTE HYDROCHLORIDE
JAN   MART.   MI   WHO-DD  
Common Name English
THYMOXAMINE HCL
Common Name English
MOXISYLYTE HYDROCHLORIDE [MART.]
Common Name English
MOXISYLYTE HYDROCHLORIDE [JAN]
Common Name English
THYMOXAMINE HYDROCHLORIDE
Common Name English
MOXISYLYTE HCL
Common Name English
Moxisylyte hydrochloride [WHO-DD]
Common Name English
MOXISYLYTE HYDROCHLORIDE [MI]
Common Name English
NSC-170448
Code English
6-ACETOXYTHYMOL 2-(DIMETHYLAMINO)ETHYL ETHER, HYDROCHLORIDE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29713
Created by admin on Fri Dec 15 15:09:01 GMT 2023 , Edited by admin on Fri Dec 15 15:09:01 GMT 2023
FDA ORPHAN DRUG 19887
Created by admin on Fri Dec 15 15:09:01 GMT 2023 , Edited by admin on Fri Dec 15 15:09:01 GMT 2023
Code System Code Type Description
MERCK INDEX
m7648
Created by admin on Fri Dec 15 15:09:01 GMT 2023 , Edited by admin on Fri Dec 15 15:09:01 GMT 2023
PRIMARY Merck Index
CAS
964-52-3
Created by admin on Fri Dec 15 15:09:01 GMT 2023 , Edited by admin on Fri Dec 15 15:09:01 GMT 2023
PRIMARY
PUBCHEM
13758
Created by admin on Fri Dec 15 15:09:01 GMT 2023 , Edited by admin on Fri Dec 15 15:09:01 GMT 2023
PRIMARY
EVMPD
SUB03343MIG
Created by admin on Fri Dec 15 15:09:01 GMT 2023 , Edited by admin on Fri Dec 15 15:09:01 GMT 2023
PRIMARY
NCI_THESAURUS
C87585
Created by admin on Fri Dec 15 15:09:01 GMT 2023 , Edited by admin on Fri Dec 15 15:09:01 GMT 2023
PRIMARY
EPA CompTox
DTXSID9046946
Created by admin on Fri Dec 15 15:09:01 GMT 2023 , Edited by admin on Fri Dec 15 15:09:01 GMT 2023
PRIMARY
NSC
170448
Created by admin on Fri Dec 15 15:09:01 GMT 2023 , Edited by admin on Fri Dec 15 15:09:01 GMT 2023
PRIMARY
ChEMBL
CHEMBL159226
Created by admin on Fri Dec 15 15:09:01 GMT 2023 , Edited by admin on Fri Dec 15 15:09:01 GMT 2023
PRIMARY
FDA UNII
WK2KZM9V6X
Created by admin on Fri Dec 15 15:09:01 GMT 2023 , Edited by admin on Fri Dec 15 15:09:01 GMT 2023
PRIMARY
ECHA (EC/EINECS)
213-519-4
Created by admin on Fri Dec 15 15:09:01 GMT 2023 , Edited by admin on Fri Dec 15 15:09:01 GMT 2023
PRIMARY
RXCUI
235778
Created by admin on Fri Dec 15 15:09:01 GMT 2023 , Edited by admin on Fri Dec 15 15:09:01 GMT 2023
PRIMARY RxNorm
SMS_ID
100000088303
Created by admin on Fri Dec 15 15:09:01 GMT 2023 , Edited by admin on Fri Dec 15 15:09:01 GMT 2023
PRIMARY
Related Record Type Details
Structure of MOXISYLYTE
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of MOXISYLYTE
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