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Details

Stereochemistry ACHIRAL
Molecular Formula C22H27ClN2O
Molecular Weight 370.916
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LORCAINIDE

SMILES

CC(C)N1CCC(CC1)N(C(=O)CC2=CC=CC=C2)C3=CC=C(Cl)C=C3

InChI

InChIKey=XHOJAWVAWFHGHL-UHFFFAOYSA-N
InChI=1S/C22H27ClN2O/c1-17(2)24-14-12-21(13-15-24)25(20-10-8-19(23)9-11-20)22(26)16-18-6-4-3-5-7-18/h3-11,17,21H,12-16H2,1-2H3

HIDE SMILES / InChI

Molecular Formula C22H27ClN2O
Molecular Weight 370.916
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Lorcainide is a class Ic antiarrhythmic medication. It was reported to be highly efficient for the treatment of ventricular arrhythmias, ventricular fibrillation, and tachycardia. The drug was used under the name Remivox. The mechanism of lorcainide action involves the blockage of sodium channels. Lorcainide was withdrawn from the market for a commercial reason, but later it was admitted that the use of the drug is associated with high risk of death.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown
Primary
Unknown
Primary
Unknown
Primary
Unknown

PubMed

Sample Use Guides

In Vivo Use Guide
Lorcainide is given orally at a dose 50-100 mg 2-3 times/day after a meal; the drug can be also administered as a slow intravenous injection at a dose of 1-2 mg for 5-10 min and the dose can be repeated every 8-12 h.
Route of Administration: Other
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
KGJ2T0N7IQ
Record Status Validated (UNII)
Record Version