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Details

Stereochemistry ACHIRAL
Molecular Formula C29H35NO2
Molecular Weight 429.5937
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of MIPROXIFENE

SMILES

CC\C(=C(/C1=CC=C(O)C=C1)C2=CC=C(OCCN(C)C)C=C2)C3=CC=C(C=C3)C(C)C

InChI

InChIKey=FVVPWVFWOOMXEZ-ZIADKAODSA-N
InChI=1S/C29H35NO2/c1-6-28(23-9-7-22(8-10-23)21(2)3)29(24-11-15-26(31)16-12-24)25-13-17-27(18-14-25)32-20-19-30(4)5/h7-18,21,31H,6,19-20H2,1-5H3/b29-28-

HIDE SMILES / InChI

Molecular Formula C29H35NO2
Molecular Weight 429.5937
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Description

TAT-59 (Miproxifene Phosphate) is a triphenylethylene analog of tamoxifen. TAT-59 is the phosphate ester prodrug of the practically insoluble parent drug DP-TAT-59. It is an antiestrogen developed in Japan for breast cancer. It is a potent antitumor agent for hormone-dependent tumors. Most of TAT-59 metabolites possessed remarkable binding affinity toward estrogenic receptors as well as fairly good antiuterotrophic activity.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

PubMed

Sample Use Guides

In Vivo Use Guide
20 mg/day
Route of Administration: Oral
In Vitro Use Guide
TAT-59 given at 1, 5, and 20 mg/kg inhibited the estrogen-stimulated growth of MCF-7 tumors in athymic mice in a dose-dependent fashion.
Substance Class Chemical
Record UNII
BGJ4Z7930W
Record Status Validated (UNII)
Record Version