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Search results for benzyl root_codes_WIKIPEDIA in WIKIPEDIA (approximate match)
Status:
US Approved OTC
Source:
21 CFR 344.12 otic:ear drying aid isopropyl alcohol
Source URL:
First marketed in 1921
Class (Stereo):
CHEMICAL (ACHIRAL)
Isopropanolamine (1-Amino-2-propanol) is a colorless to yellowish liquid with an amine-like odor. It is miscible in water. Intermediate used in the production of dyes, lubrification oils, corrosion inhibitor, detergents, cutting fluids.
Status:
US Approved OTC
Source:
21 CFR 346.10(b) anorectal:local anesthetic benzyl alcohol
Source URL:
First marketed in 1921
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Benzyl Alcohol is an aromatic alcohol used in a wide variety of cosmetic formulations as a fragrance component, preservative, solvent, and viscosity-decreasing agent. FDA agency approved benzyl alcohol for the treatment of head lice. The drug acts on head lice by inhibiting them from closing their respiratory spiracles, allowing the vehicle to obstruct the spiracles and causing the lice to asphyxiate.
Status:
Investigational
Source:
NCT02357888: Phase 2 Interventional Completed Healthy Highly Dependant Smokers
(2015)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Vanillyl alcohol is a monomethoxybenzene that is 2-methoxyphenol substituted by a hydroxymethyl group at position 4. It has a role as a plant metabolite. It is a member of guaiacols and a member of benzyl alcohols. Vanillyl alcohol is a phenolic alcohol and is used as a flavoring agent in foods and beverages. Vanillyl alcohol effectively inhibited the cytotoxicity and improved cell viability in MPP+-induced MN9D dopaminergic cells. Vanillyl alcohol attenuated the elevation of reactive oxygen species (ROS) levels, decreased in the Bax/Bcl-2 ratio and poly (ADP-ribose) polymerase proteolysis. These results indicate that vanillyl alcohol protected dopaminergic MN9D cells against MPP+-induced apoptosis by relieving oxidative stress and modulating the apoptotic process and is therefore a potential candidate for treatment of neurodegenerative diseases such as Parkinson's disease.
Status:
Investigational
Source:
NCT00608634: Phase 2 Interventional Completed Precancerous Condition
(2004)
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
The monoterpene perillyl alcohol (POH) is a naturally occurring compound derived from citrus fruits, mint, and herbs. It exhibited chemotherapeutic potential against various malignant tumors in preclinical models and was being tested in clinical trials in patients with refractory advanced cancers. POH was formulated in soft gelatine capsules and orally administered to cancer patients several times a day on a continuous basis. However, such clinical trials in humans yielded disappointing results, also because of the large number of capsules that had to be swallowed caused hard-to-tolerate intestinal side effects, causing many patients to withdraw from treatment due to unrelenting nausea, fatigue, and vomiting. The clinical trials in Brazil have explored intranasal POH delivery as an alternative to circumvent the toxic limitations of oral administration. In these trials, patients with recurrent malignant gliomas were given comparatively small doses of POH via simple inhalation through the nose. Results from these studies showed, that this type of long-term, daily chemotherapy was well tolerated and effective. The precise mechanism of action is still undetermined, but it is known, that perillyl alcohol plays an important role in the process of hepatoma cell invasion and migration via decreasing the activity of Notch signaling pathway and increasing E-cadherin expression regulated by Snail. Another possible mechanism is included inhibition of Na/K-ATPase (NKA). The NKA α1 subunit is known to be superexpresses in glioblastoma cells (GBM) and POH acts in signaling cascades associated with NKA can control cell proliferation and/or cellular death.
Benzyl butyl phthalate is used as a plasticizer for polyvinyl chloride in vinyl floor tiles, vinyl foam and carpet backing, in cellulosic resins, and as an organic intermediate. It has also been used as a solvent and fixative in perfume. It is a colorless and odorless organic chemical. Exposure to benzyl butyl phthalate occurs during its production and use as a plasticizer, mainly in polyvinyl chloride products. It has been detected at low levels in indoor air, water, and a few foods. Benzyl butyl phthalate is classified as a substance toxic to reproduction. It demonstrated estrogen and anti-androgen activity. Prenatal exposure to phthalates could lead to smaller penis size and incomplete descent of testicles in baby boys.