Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C7H8O |
| Molecular Weight | 108.1378 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OCC1=CC=CC=C1
InChI
InChIKey=WVDDGKGOMKODPV-UHFFFAOYSA-N
InChI=1S/C7H8O/c8-6-7-4-2-1-3-5-7/h1-5,8H,6H2
| Molecular Formula | C7H8O |
| Molecular Weight | 108.1378 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: description was created based on several sources, including, http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022129s005lbl.pdf
Curator's Comment: description was created based on several sources, including, http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022129s005lbl.pdf
Benzyl Alcohol is an aromatic alcohol used in a wide variety of cosmetic formulations as a fragrance component, preservative, solvent, and viscosity-decreasing agent. FDA agency approved benzyl alcohol for the treatment of head lice. The drug acts on head lice by inhibiting them from closing their respiratory spiracles, allowing the vehicle to obstruct the spiracles and causing the lice to asphyxiate.
Originator
Approval Year
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
34.8 μM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/27019966/ |
0.46 mmol single, subcutaneous dose: 0.46 mmol route of administration: Subcutaneous experiment type: SINGLE co-administered: NANDROLONE DECANOATE |
BENZYL ALCOHOL serum | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: UNKNOWN |
|
1.8 μM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/27019966/ |
0.46 mmol single, subcutaneous dose: 0.46 mmol route of administration: Subcutaneous experiment type: SINGLE co-administered: NANDROLONE DECANOATE |
BENZOIC ACID serum | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: UNKNOWN |
|
16.6 μM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/27019966/ |
0.46 mmol single, subcutaneous dose: 0.46 mmol route of administration: Subcutaneous experiment type: SINGLE co-administered: NANDROLONE DECANOATE |
HIPPURIC ACID serum | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: UNKNOWN |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
397.3 μM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/27019966/ |
0.46 mmol single, subcutaneous dose: 0.46 mmol route of administration: Subcutaneous experiment type: SINGLE co-administered: NANDROLONE DECANOATE |
BENZYL ALCOHOL serum | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: UNKNOWN |
|
417.4 μM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/27019966/ |
0.46 mmol single, subcutaneous dose: 0.46 mmol route of administration: Subcutaneous experiment type: SINGLE co-administered: NANDROLONE DECANOATE |
BENZOIC ACID serum | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: UNKNOWN |
|
7113.6 μM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/27019966/ |
0.46 mmol single, subcutaneous dose: 0.46 mmol route of administration: Subcutaneous experiment type: SINGLE co-administered: NANDROLONE DECANOATE |
HIPPURIC ACID serum | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: UNKNOWN |
Doses
| Dose | Population | Adverse events |
|---|---|---|
234 mg/kg multiple, intravenous Overdose Dose: 234 mg/kg Route: intravenous Route: multiple Dose: 234 mg/kg Sources: |
unhealthy, 29 weeks (range: 26-34 weeks) Health Status: unhealthy Age Group: 29 weeks (range: 26-34 weeks) Sources: |
Disc. AE: Toxic reaction (NOS)... AEs leading to discontinuation/dose reduction: Toxic reaction (NOS) (grade 5, 2 patients) Sources: |
AEs
| AE | Significance | Dose | Population |
|---|---|---|---|
| Toxic reaction (NOS) | grade 5, 2 patients Disc. AE |
234 mg/kg multiple, intravenous Overdose Dose: 234 mg/kg Route: intravenous Route: multiple Dose: 234 mg/kg Sources: |
unhealthy, 29 weeks (range: 26-34 weeks) Health Status: unhealthy Age Group: 29 weeks (range: 26-34 weeks) Sources: |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Isolation and characterization of a pseudomonas strain that degrades 4-acetamidophenol and 4-aminophenol. | 2001 |
|
| Effect of benzene, toluene, xylene on the semen quality and the function of accessory gonad of exposed workers. | 2001 Apr |
|
| Biotransformations catalyzed by cloned p-cymene monooxygenase from Pseudomonas putida F1. | 2001 Apr |
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| Benzylidene analogs of anabaseine display partial agonist and antagonist properties at the mouse 5-hydroxytryptamine(3A) receptor. | 2001 Dec |
|
| Assembly of a robust, thermally stable porous cobalt(II) nicotinate framework based on a dicobalt carboxylate unit. | 2001 Dec 3 |
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| Prochiral selectivity in H(2)O(2)-promoted oxidation of arylalkanols catalysed by chloroperoxidase. The role of the interactions between the OH group and the amino-acid residues in the enzyme active site. | 2001 Feb |
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| Metabolic engineering of bacteria for environmental applications: construction of Pseudomonas strains for biodegradation of 2-chlorotoluene. | 2001 Feb 13 |
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| Racemization kinetics of meluadrine tartrate in aqueous solution. | 2001 Jan |
|
| Three double-blind, randomized trials evaluating the safety and tolerance of different formulations of the saponin adjuvant QS-21. | 2001 Jul 16 |
|
| Mutagenicity of electrophilic N-acyloxy-N-alkoxyamides. | 2001 Jul 25 |
|
| Chemical composition and behavioral responses of the marine insect Halobates hawaiiensis (Heteroptera: Gerridae). | 2001 Jul-Aug |
|
| Rhenium(I) carbonyl complexes of 2,4,6-tris(2-pyridyl)-1,3,5-triazine (TPT). Rhenium(I)-promoted methoxylation of the triazine ring carbon atom in dinuclear rhenium complexes. | 2001 Jun 4 |
|
| Biphasic membrane effects of capsaicin, an active component in Capsicum species. | 2001 May |
|
| Quantitative detection of aromatic compounds in single aerosol particle mass spectrometry. | 2001 May 15 |
|
| A concise total synthesis of the azaphenanthrene alkaloid eupolauramine. | 2001 Nov 30 |
|
| Volatiles from Ficus hispida and their attractiveness to fig wasps. | 2001 Oct |
|
| Metabolism and disposition of the novel antileukaemic drug, benzamide riboside, in the isolated perfused rat liver. | 2001 Oct 12 |
|
| Redox chemistry of morpholine-based Os(VI)-hydrazido complexes: trans-[Os(VI)(tpy)(Cl)2(NN(CH2)4O)](2+). | 2001 Sep 24 |
|
| Susceptibility to the ototoxic properties of toluene is species specific. | 2002 Apr |
|
| Characterization of paint samples used in drinking water reservoirs: identification of endocrine disruptor compounds. | 2002 Apr |
|
| The depth of porphyrin in a membrane and the membrane's physical properties affect the photosensitizing efficiency. | 2002 Apr |
|
| An MCASE approach to the search of a cure for Parkinson's Disease. | 2002 Apr 2 |
|
| Composition of the volatiles from intact and mechanically pierced tea aphid-tea shoot complexes and their attraction to natural enemies of the tea aphid. | 2002 Apr 24 |
|
| Identification of a protein-promoting vibration in the reaction catalyzed by horse liver alcohol dehydrogenase. | 2002 Apr 3 |
|
| Preparation of soluble and insoluble polymer supported IBX reagents. | 2002 Aug 5 |
|
| The effect of the nature of H-bonding groups on diffusion through PDMS membranes saturated with octanol and toluene. | 2002 Feb |
|
| Disposition of 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'- (methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)- 1H-pyrazole-5-carboxamide (DPC 423) by novel metabolic pathways. Characterization of unusual metabolites by liquid chromatography/mass spectrometry and NMR. | 2002 Jan |
|
| Effects of butylated hydroxyanisole and butylated hydroxytoluene on DNA adduct formation and arylamine N-acetyltransferase activity in human bladder tumour cells. | 2002 Jan-Feb |
|
| Mineralization of aromatic compounds by brown-rot basidiomycetes - mechanisms involved in initial attack on the aromatic ring. | 2002 Jun |
|
| A new amperometric enzyme electrode for alcohol determination. | 2002 Jun |
|
| Investigation of polymeric nanoparticles as carriers of enalaprilat for oral administration. | 2002 Jun 4 |
|
| Microwave-driven zeolite-guest systems show athermal effects from nonequilibrium molecular dynamics. | 2002 Jun 5 |
|
| Hydroxy-substituted oligopyridine dicarboxamide helical foldamers. | 2002 Mar 21 |
|
| Catalytic degradation of CH2O and C6H5CH2OH in wastewaters. | 2002 May |
|
| Comparison of the antioxidant properties of HYAFF-11p75, AQUACEL and hyaluronan towards reactive oxygen species in vitro. | 2002 May |
|
| Essential oil constituents and in vitro antimicrobial activity of Decalepis hamiltonii roots against foodborne pathogens. | 2002 May 22 |
|
| The mediation of veratryl alcohol in oxidations promoted by lignin peroxidase: the lifetime of veratryl alcohol radical cation. | 2002 May 3 |
|
| Diastereoselective reactions of delta-oxy-substituted allylic acetates with organocopper reagents. | 2002 May 3 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 17:55:25 GMT 2025
by
admin
on
Mon Mar 31 17:55:25 GMT 2025
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| Record UNII |
LKG8494WBH
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| Record Status |
Validated (UNII)
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| Record Version |
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| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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JECFA EVALUATION |
BENZYL ALCOHOL
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NCI_THESAURUS |
C28394
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NDF-RT |
N0000181811
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JECFA EVALUATION |
INS-1519
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EC SCIENTIFIC COMMITTEE ON CONSUMER SAFETY OPINION |
SCCS/1459/11
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EPA PESTICIDE CODE |
9502
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WHO-ATC |
P03AX06
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CFR |
21 CFR 172.515
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| Code System | Code | Type | Description | ||
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310
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BENZYL ALCOHOL
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DTXSID5020152
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8044
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C77028
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17987
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m2397
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PRIMARY | Merck Index | ||
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202-859-9
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LKG8494WBH
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100000086395
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BENZYL ALCOHOL
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PRIMARY | Description: A clear, colourless, oily liquid; odour, slightly aromatic. Solubility: Soluble in water; miscible with ethanol (~750 g/l) TS, ether R, fatty and essential oils. Category: Antimicrobial preservative. Storage: Benzyl alcohol should be kept in a tightly closed container, protected from light. Additional information: Benzyl alcohol is affected by air and light, and should be protected from exposure to excessive heat. | ||
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100-51-6
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CHEMBL720
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DB06770
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SUB05771MIG
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334
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45
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D019905
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923
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1061901
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1426
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244
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LKG8494WBH
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
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IMPURITY -> PARENT |
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
http://apps.who.int/phint/pdf/b/Jb.6.1.50.pdf
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