Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C7H8O |
| Molecular Weight | 108.1378 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OCC1=CC=CC=C1
InChI
InChIKey=WVDDGKGOMKODPV-UHFFFAOYSA-N
InChI=1S/C7H8O/c8-6-7-4-2-1-3-5-7/h1-5,8H,6H2
| Molecular Formula | C7H8O |
| Molecular Weight | 108.1378 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: description was created based on several sources, including, http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022129s005lbl.pdf
Curator's Comment: description was created based on several sources, including, http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022129s005lbl.pdf
Benzyl Alcohol is an aromatic alcohol used in a wide variety of cosmetic formulations as a fragrance component, preservative, solvent, and viscosity-decreasing agent. FDA agency approved benzyl alcohol for the treatment of head lice. The drug acts on head lice by inhibiting them from closing their respiratory spiracles, allowing the vehicle to obstruct the spiracles and causing the lice to asphyxiate.
Originator
Approval Year
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
34.8 μM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/27019966/ |
0.46 mmol single, subcutaneous dose: 0.46 mmol route of administration: Subcutaneous experiment type: SINGLE co-administered: NANDROLONE DECANOATE |
BENZYL ALCOHOL serum | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: UNKNOWN |
|
1.8 μM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/27019966/ |
0.46 mmol single, subcutaneous dose: 0.46 mmol route of administration: Subcutaneous experiment type: SINGLE co-administered: NANDROLONE DECANOATE |
BENZOIC ACID serum | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: UNKNOWN |
|
16.6 μM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/27019966/ |
0.46 mmol single, subcutaneous dose: 0.46 mmol route of administration: Subcutaneous experiment type: SINGLE co-administered: NANDROLONE DECANOATE |
HIPPURIC ACID serum | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: UNKNOWN |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
397.3 μM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/27019966/ |
0.46 mmol single, subcutaneous dose: 0.46 mmol route of administration: Subcutaneous experiment type: SINGLE co-administered: NANDROLONE DECANOATE |
BENZYL ALCOHOL serum | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: UNKNOWN |
|
417.4 μM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/27019966/ |
0.46 mmol single, subcutaneous dose: 0.46 mmol route of administration: Subcutaneous experiment type: SINGLE co-administered: NANDROLONE DECANOATE |
BENZOIC ACID serum | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: UNKNOWN |
|
7113.6 μM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/27019966/ |
0.46 mmol single, subcutaneous dose: 0.46 mmol route of administration: Subcutaneous experiment type: SINGLE co-administered: NANDROLONE DECANOATE |
HIPPURIC ACID serum | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: UNKNOWN |
Doses
| Dose | Population | Adverse events |
|---|---|---|
234 mg/kg multiple, intravenous Overdose Dose: 234 mg/kg Route: intravenous Route: multiple Dose: 234 mg/kg Sources: |
unhealthy, 29 weeks (range: 26-34 weeks) Health Status: unhealthy Age Group: 29 weeks (range: 26-34 weeks) Sources: |
Disc. AE: Toxic reaction (NOS)... AEs leading to discontinuation/dose reduction: Toxic reaction (NOS) (grade 5, 2 patients) Sources: |
AEs
| AE | Significance | Dose | Population |
|---|---|---|---|
| Toxic reaction (NOS) | grade 5, 2 patients Disc. AE |
234 mg/kg multiple, intravenous Overdose Dose: 234 mg/kg Route: intravenous Route: multiple Dose: 234 mg/kg Sources: |
unhealthy, 29 weeks (range: 26-34 weeks) Health Status: unhealthy Age Group: 29 weeks (range: 26-34 weeks) Sources: |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Preparation of soluble and insoluble polymer supported IBX reagents. | 2002-08-05 |
|
| Microwave-driven zeolite-guest systems show athermal effects from nonequilibrium molecular dynamics. | 2002-06-05 |
|
| Investigation of polymeric nanoparticles as carriers of enalaprilat for oral administration. | 2002-06-04 |
|
| SAR and species/stereo-selective metabolism of the sorbitol dehydrogenase inhibitor, CP-470,711. | 2002-06-03 |
|
| Mineralization of aromatic compounds by brown-rot basidiomycetes - mechanisms involved in initial attack on the aromatic ring. | 2002-06 |
|
| A new amperometric enzyme electrode for alcohol determination. | 2002-06 |
|
| Essential oil constituents and in vitro antimicrobial activity of Decalepis hamiltonii roots against foodborne pathogens. | 2002-05-22 |
|
| The mediation of veratryl alcohol in oxidations promoted by lignin peroxidase: the lifetime of veratryl alcohol radical cation. | 2002-05-03 |
|
| Diastereoselective reactions of delta-oxy-substituted allylic acetates with organocopper reagents. | 2002-05-03 |
|
| Catalytic degradation of CH2O and C6H5CH2OH in wastewaters. | 2002-05 |
|
| Comparison of the antioxidant properties of HYAFF-11p75, AQUACEL and hyaluronan towards reactive oxygen species in vitro. | 2002-05 |
|
| Composition of the volatiles from intact and mechanically pierced tea aphid-tea shoot complexes and their attraction to natural enemies of the tea aphid. | 2002-04-24 |
|
| Identification of a protein-promoting vibration in the reaction catalyzed by horse liver alcohol dehydrogenase. | 2002-04-03 |
|
| An MCASE approach to the search of a cure for Parkinson's Disease. | 2002-04-02 |
|
| Susceptibility to the ototoxic properties of toluene is species specific. | 2002-04 |
|
| Characterization of paint samples used in drinking water reservoirs: identification of endocrine disruptor compounds. | 2002-04 |
|
| The depth of porphyrin in a membrane and the membrane's physical properties affect the photosensitizing efficiency. | 2002-04 |
|
| Yeast-mediated preparation of l-PAC in an organic solvent. | 2002-03-30 |
|
| Hydroxy-substituted oligopyridine dicarboxamide helical foldamers. | 2002-03-21 |
|
| Copper-catalyzed coupling of aryl iodides with aliphatic alcohols. | 2002-03-21 |
|
| Volatiles from rhizomes of Rhodiola rosea L. | 2002-03 |
|
| The discovery of PD 89211 and related compounds: selective dopamine D4 receptor antagonists. | 2002-02 |
|
| The effect of the nature of H-bonding groups on diffusion through PDMS membranes saturated with octanol and toluene. | 2002-02 |
|
| Physico-chemical properties and degradability of non-woven hyaluronan benzylic esters as tissue engineering scaffolds. | 2002-02 |
|
| Rate sensitivity of shear-induced changes in the lateral diffusion of endothelial cell membrane lipids: a role for membrane perturbation in shear-induced MAPK activation. | 2002-02 |
|
| Flash photolytic generation of o-quinone alpha-phenylmethide and o-quinone alpha-(p-anisyl)methide in aqueous solution and investigation of their reactions in that medium. Saturation of acid-catalyzed hydration. | 2002-01-30 |
|
| Effects of butylated hydroxyanisole and butylated hydroxytoluene on DNA adduct formation and arylamine N-acetyltransferase activity in human bladder tumour cells. | 2002-01-25 |
|
| The deprotonation of benzyl alcohol radical cations: a mechanistic dichotomy in the gas phase as in solution. | 2002-01-18 |
|
| The ability of various chemicals to elicit olfactory beta-waves in the pyriform cortex of meadow voles (Microtus pennsylvanicus) and laboratory rats (Rattus norvegicus). | 2002-01-11 |
|
| Sorption of benzoic acid, sorbic acid, benzyl alcohol, and benzalkonium chloride by flexible tubing. | 2002-01 |
|
| Disposition of 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'- (methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)- 1H-pyrazole-5-carboxamide (DPC 423) by novel metabolic pathways. Characterization of unusual metabolites by liquid chromatography/mass spectrometry and NMR. | 2002-01 |
|
| A novel, tunable manganese coordination system based on a flexible "spacer" unit: noncovalent templation effects. | 2001-12-05 |
|
| Dynamic structures of horse liver alcohol dehydrogenase (HLADH): results of molecular dynamics simulations of HLADH-NAD(+)-PhCH(2)OH, HLADH-NAD(+)-PhCH(2)O(-), and HLADH-NADH-PhCHO. | 2001-12-05 |
|
| Assembly of a robust, thermally stable porous cobalt(II) nicotinate framework based on a dicobalt carboxylate unit. | 2001-12-03 |
|
| Bilirubin-albumin binding and free bilirubin. | 2001-12 |
|
| Wound healing activity of human placental extracts in rats. | 2001-12 |
|
| Competitive binding of aroma compounds by beta-cyclodextrin. | 2001-12 |
|
| Isolated mental developmental delay in very low birth weight infants: association with prolonged doxapram therapy for apnea. | 2001-12 |
|
| Mechanism of cytochrome P4503A4- and 2D6-catalyzed dehydrogenation of ezlopitant as probed with isotope effects using five deuterated analogs. | 2001-12 |
|
| Benzylidene analogs of anabaseine display partial agonist and antagonist properties at the mouse 5-hydroxytryptamine(3A) receptor. | 2001-12 |
|
| Inhibition of malonaldehyde formation from blood plasma oxidation by aroma extracts and aroma components isolated from clove and eucalyptus. | 2001-12 |
|
| A concise total synthesis of the azaphenanthrene alkaloid eupolauramine. | 2001-11-30 |
|
| Benzyl alcohol with epinephrine as an alternative to lidocaine with epinephrine. | 2001-11 |
|
| Metabolism and disposition of the novel antileukaemic drug, benzamide riboside, in the isolated perfused rat liver. | 2001-10-12 |
|
| Biotransformation of benzaldehyde into (R)-phenylacetylcarbinol by filamentous fungi or their extracts. | 2001-10 |
|
| Volatiles from Ficus hispida and their attractiveness to fig wasps. | 2001-10 |
|
| Redox chemistry of morpholine-based Os(VI)-hydrazido complexes: trans-[Os(VI)(tpy)(Cl)2(NN(CH2)4O)](2+). | 2001-09-24 |
|
| Pharmacodynamics of intravenous and subcutaneous tinzaparin and heparin in healthy volunteers. | 2001-09-01 |
|
| Isolation and characterization of a pseudomonas strain that degrades 4-acetamidophenol and 4-aminophenol. | 2001 |
|
| Final report on the safety assessment of Benzyl Alcohol, Benzoic Acid, and Sodium Benzoate. | 2001 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 17:55:25 GMT 2025
by
admin
on
Mon Mar 31 17:55:25 GMT 2025
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| Record UNII |
LKG8494WBH
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| Record Status |
Validated (UNII)
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| Record Version |
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| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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JECFA EVALUATION |
BENZYL ALCOHOL
Created by
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NCI_THESAURUS |
C28394
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NDF-RT |
N0000181811
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JECFA EVALUATION |
INS-1519
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EC SCIENTIFIC COMMITTEE ON CONSUMER SAFETY OPINION |
SCCS/1459/11
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EPA PESTICIDE CODE |
9502
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WHO-ATC |
P03AX06
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CFR |
21 CFR 172.515
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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310
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BENZYL ALCOHOL
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DTXSID5020152
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8044
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C77028
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17987
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m2397
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PRIMARY | Merck Index | ||
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202-859-9
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LKG8494WBH
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100000086395
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BENZYL ALCOHOL
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PRIMARY | Description: A clear, colourless, oily liquid; odour, slightly aromatic. Solubility: Soluble in water; miscible with ethanol (~750 g/l) TS, ether R, fatty and essential oils. Category: Antimicrobial preservative. Storage: Benzyl alcohol should be kept in a tightly closed container, protected from light. Additional information: Benzyl alcohol is affected by air and light, and should be protected from exposure to excessive heat. | ||
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100-51-6
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CHEMBL720
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DB06770
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SUB05771MIG
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334
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45
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D019905
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923
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1061901
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1426
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244
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LKG8494WBH
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
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IMPURITY -> PARENT |
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
http://apps.who.int/phint/pdf/b/Jb.6.1.50.pdf
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