Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Omipalisib, also known as GSK2126458, is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity. Omipalisib (GSK2126458, GSK458) is a highly selective and potent inhibitor of p110α...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Vistusertib (AZ-2014) is a dual inhibitor of mTORC1/mTORC2 which was developed by AstraZeneca for the treatment of cancer. The drug is under clinical development (phase II) in patients with Renal Carcinoma, Squamous Non Small Cell Lung Cancer, Diffus...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
LY3023414, an investigational drug, is a small molecule that that demonstrates activity against PI3K, mTOR, and DNA-PK in tumor cells, thereby inducing cell-cycle effects and inhibiting cancer cell viability. As shown in vitro LY3023414 inhibits the ...
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
OSI-027 is an orally bioavailable mammalian inhibitor of mTOR kinase and has antineoplastic activity. OSI-027 binds to and inhibits of the catalytic site of mTOR, which is a central part of two protein complexes, mTORC1 and mTORC2, which may result i...
Class (Stereo):
CHEMICAL (ACHIRAL)
Sapanisertib is an oral dual inhibitor of mTORC1/mTORC2, discovered by Intellikine for the treatment of cancer. The drug is being tested in phase II of clinical trials for different cancers among which are sarcoma, hepatocellular carcinoma, etc. The ...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
AstraZeneca was developing AZD-8055, an orally active mTORC1/mTORC2 inhibitor, for the treatment of advanced solid tumours. AZD-8055 is an ATP-competitive mTORC1/2 inhibitor that exhibits immunosuppressive and anticancer chemotherapeutic activities. ...
Class (Stereo):
CHEMICAL (RACEMIC)
RES-529 (previously named Palomid 529, P529) is a phosphoinositide 3-kinase (PI3K)/AKT/mechanistic target of rapamycin (mTOR) pathway inhibitor that interferes with the pathway through both mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2) dissocia...
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Torin 1 is a highly potent and selective ATP-competitive mTOR inhibitor discovered as a potential anticancer drug. It directly inhibits two functionally distinct complexes, mTORC1 and mTORC2, that coordinately promote cell growth, proliferation, and ...
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
XL388 is a selective small-molecule ATP-competitive inhibitor of mTOR kinase complexes mTORC1 and mTORC2. XL388 inhibited cellular phosphorylation of mTOR complex 1 (p-p70S6K, pS6, and p-4E-BP1) and mTOR complex 2 (pAKT (S473)) substrates. In vitro, ...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Leucine is an α-amino acid used in the biosynthesis of proteins. Leucine is an essential hydrophobic amino acid. It is used in the Leucine may be used some people as a supplement to build muscle. Leucine is also found in fish, meat, and poultry. In ...