Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Tapinarof (also known as benvitimod, WB-1001; GSK-2894512), a therapeutic aryl hydrocarbon receptor agonist that selectively modulates the cytokine cascade deep under the skin, a process that rapidly decreases inflammations and skin plague. Tapinaro...
Class (Stereo):
CHEMICAL (RACEMIC)
Targets:
Conditions:
Ketoconazole is an azole antifungal. Ketoconazole was the first broad-spectrum oral antifungal agent available to treat systemic and superficial mycoses. Evidence of hepatotoxicity associated with its use emerged within the first few years of its app...
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Mivotilate is an orally active hepatoprotective agent for the treatment of liver cirrhosis and hepatitis-B infection. Mivotilate was shown to exert multiple effects on the hepatic cytochrome P450 system, particularly to inhibit CYP2E1 expression and ...
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Kynurenic acid is a product of the normal metabolism of amino acid L-tryptophan which has been shown to have a neuroactive profile. It exhibits activity against NMDA receptors and Neuronal acetylcholine receptor subunit alpha-7. It has been investiga...
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Indole-3-carbinol (I3C), a common phytochemical in cruciferous vegetables, and its condensation product, 3,3'-diindolylmethane (DIM) exert several biological activities on cellular and molecular levels, which contribute to their well-recognized chemo...
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
The compound StemRegenin 1 (SR1) is a selective, cell-permeable, small molecule that promotes the self-renewal of human hematopoietic stem cells in culture. SR1 is an antagonist of the aryl hydrocarbon receptor. SR1 is the first small molecule that p...
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
3-Methylcholanthrene a compound, which can activate both aryl hydrocarbon receptor (AhR) and estrogen receptor alpha. It is used to induce fibrosarcomas and skin carcinomas in laboratory animals. The daily exposure to 3-methylcholanthrene induced cha...
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Pifithrin-alpha is a small molecule p53 functional inhibitor reported to behave like an antiapoptotic agent in neurodegenerative models. Pifithrin-alpha is a prodrug that under physiological conditions
spontaneously undergoes ring closure to yield pi...
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Evodiamine, a naturally occurring indole alkaloid, is one of the main bioactive ingredients of Evodia Rutaecara, the dried unripe fruit of which is also known as Wu zhu yu (Wu Zhu Yu, interchangeably) or Evodia Fruit. Evodia Fruit used in Traditional...
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
CH223191 is a ligand-selective antagonist of the aryl hydrocarbon (dioxin) receptor (AhR), a ligand-dependent transcription factor that produces a wide range of biological and toxic effects in many species and tissues.