Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C24H23N5OS |
| Molecular Weight | 429.537 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)N1C=NC2=C1N=C(N=C2NCCC3=CC=C(O)C=C3)C4=CSC5=C4C=CC=C5
InChI
InChIKey=BGFHMYJZJZLMHW-UHFFFAOYSA-N
InChI=1S/C24H23N5OS/c1-15(2)29-14-26-21-23(25-12-11-16-7-9-17(30)10-8-16)27-22(28-24(21)29)19-13-31-20-6-4-3-5-18(19)20/h3-10,13-15,30H,11-12H2,1-2H3,(H,25,27,28)
| Molecular Formula | C24H23N5OS |
| Molecular Weight | 429.537 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: Description was created based on several sources, including: http://www.stemcell.com/en/Products/All-Products/StemRegenin-1.aspx and https://www.caymanchem.com/product/10625
Curator's Comment: Description was created based on several sources, including: http://www.stemcell.com/en/Products/All-Products/StemRegenin-1.aspx and https://www.caymanchem.com/product/10625
The compound StemRegenin 1 (SR1) is a selective, cell-permeable, small molecule that promotes the self-renewal of human hematopoietic stem cells in culture. SR1 is an antagonist of the aryl hydrocarbon receptor. SR1 is the first small molecule that promotes robust expansion/self-renewal of human CD34 peripheral blood and cord blood hematopoietic stem cells (HSCs). The culture of HSCs with SR1 led to a 50-fold increase in cells expressing CD34 and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice. SR1 can be potentially used for ex vivo expansion of normal HSCs or leukemic stem/progenitor cells
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: WP2849 |
|||
Target ID: P35869 Gene ID: 196.0 Gene Symbol: AHR Target Organism: Homo sapiens (Human) |
127.0 nM [IC50] |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Unknown Approved UseUnknown |
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| Primary | Unknown Approved UseUnknown |
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| Primary | Unknown Approved UseUnknown |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. | 2010 Sep 10 |
|
| Rapid expansion of human hematopoietic stem cells by automated control of inhibitory feedback signaling. | 2012 Feb 3 |
|
| Efficient generation, purification, and expansion of CD34(+) hematopoietic progenitor cells from nonhuman primate-induced pluripotent stem cells. | 2012 Sep 27 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 15:15:51 GMT 2023
by
admin
on
Sat Dec 16 15:15:51 GMT 2023
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| Record UNII |
RNE1V1F9O1
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| Record Status |
Validated (UNII)
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| Record Version |
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1227633-49-9
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admin on Sat Dec 16 15:15:51 GMT 2023 , Edited by admin on Sat Dec 16 15:15:51 GMT 2023
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| Related Record | Type | Details | ||
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TARGET -> INHIBITOR |
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ACTIVE MOIETY |
LHD221, an AHR antagonist facilitates the expansion of CD34-positive hematopoietic progenitors and impedes HSPC differentiation during cytokine-driven expansion in culture.
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