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Showing 1 - 10 of 207 results

Status:
US Approved Rx (2008)
First approved in 2001

Class (Stereo):
CHEMICAL (ABSOLUTE)



Galantamine (RAZADYNE®, galantamine hydrobromide) is a benzazepine derived from norbelladine. It is found in Galanthus and other Amaryllidaceae. It is a reversible, competitive acetylcholinesterase inhibitor that is used for the treatment of mild to ...
Status:
US Approved Rx (2012)
First approved in 2000

Class (Stereo):
CHEMICAL (ABSOLUTE)



Rivastigmine (sold under the trade name Exelon) is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease. Rivastigmine, an acetylcholinesterase inhibi...
Status:
US Approved Rx (2014)
First approved in 1996

Class (Stereo):
CHEMICAL (RACEMIC)



Donepezil, marketed under the trade name Aricept, is a medication used in the palliative treatment of Alzheimer's disease. Aricept is indicated for the treatment of dementia of the Alzheimer’s type. Efficacy has been demonstrated in patients with mil...
Status:
US Approved Rx (2006)
First approved in 1995

Class (Stereo):
CHEMICAL (ACHIRAL)



Glimepiride, like glyburide and glipizide, is a "second-generation" sulfonylurea agents. Glimepiride is used with diet to lower blood glucose by increasing the secretion of insulin from pancreas and increasing the sensitivity of peripheral tissues to...
Status:
US Approved Rx (2012)
First approved in 1982

Class (Stereo):
CHEMICAL (RACEMIC)



Malathion is an organophosphate insecticide, an inhibitor of cholinesterase. In low doses (0.5%) malathion is used for treatment of pediculosis and scabies.
Status:
US Approved Rx (1972)
First approved in 1972

Class (Stereo):
CHEMICAL (ACHIRAL)



Carbachol is a potent cholinergic (parasympathomimetic) agent which produces constriction of the iris and ciliary body resulting in reduction in intraocular pressure.
Status:
US Approved Rx (1993)
First approved in 1966

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Acetylcholine is the neurotransmitter at neuromuscular junctions, at synapses in the ganglia of the visceral motor system, and at a variety of sites within the central nervous system. Whereas a great deal is known about the function of cholinergic tr...
Status:
US Approved Rx (1964)
First approved in 1964

Class (Stereo):
CHEMICAL (ACHIRAL)



Pralidoxime is a cholinesterase reactivator used as the antidote to organophosphate pesticides or acetylcholinesterase inhibitors (nerve agents) in conjunction with atropine and diazepam. Organophosphates bind to the esteratic site of acetylcholinest...
Status:
US Approved Rx (1955)
First approved in 1955

Class (Stereo):
CHEMICAL (ACHIRAL)



Acquired myasthenia gravis (MG) is a chronic autoimmune disorder of the neuromuscular junction, characterized clinically by muscle weakness and abnormal fatigability on exertion. Current guidelines and recommendations for MG treatment are based large...
Status:
US Approved Rx (2019)
First marketed in 1931

Class (Stereo):
CHEMICAL (ACHIRAL)



Neostigmine is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier. By inhi...