U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

    {{facet.count}}
    {{facet.count}}

Showing 651 - 660 of 1447 results

Status:
Possibly Marketed Outside US
Source:
Japan:Methylmethionine Sulfonium Chloride
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



METHYLMETHIONINE (S-Methionine methyl sulfonium, SMMS) chloride is a derivative of methionine metabolism in some plants. Methylmethionine has therapeutic effects on gastrointestinal ulceration potentially via its ability to promote dermal fibroblast migration and growth. The natural derivative Methylmethionine is biosynthesized from L-methionine which is first converted to S-adenosylmethionine. The subsequent conversion, involving replacement of the adenosyl group by a methyl group is catalyzed by the enzyme methionine S-methyltransferase. Methylmethionine is particularly abundant in plants, being more abundant than methionine. S-Methylmethionine is sometimes referred to as vitamin U, but it is not considered a true vitamin. The term was coined in 1950 by Garnett Cheney for uncharacterized anti-ulcerogenic factors in raw cabbage juice that may help speed healing of peptic ulcers.
Status:
Possibly Marketed Outside US
Source:
Noopept by CJSC LEKKO Pharmaceuticals
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Noopept (DVD-111) is a peptide promoted and prescribed in Russia and neighbouring countries as a nootropic. Noopept was patented by Russian-based pharmaceutical company JSC LEKKO Pharmaceuticals in the 1996. Research shows Noopept has similar effects, but works differently than other nootropics in the racetam-family. The compound is patented in both the US and Russia with patent of Russian Federation number 2119496, U.S. Patent 5,439,930 issued 8/8/1995. Noopept exhibits a combined neuroprotector effect both in vitro and in vivo. Noopept decreases the extent of necrotic damage caused by photoinduced thrombosis of cortical blood vessels. It was established that the neuroprotector effect of noopept is related to its action upon the well-known "triad", whereby the drug reduces neurotoxic effects of excess extracellular calcium, glutamate, and free radicals. Two additional components of the neuroprotector action of noopept are related to the antiinflammatory and antithrombotic activity.
Status:
Possibly Marketed Outside US
Source:
Ovestin 1 mg cream
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Estriol tripropionate (brand name Estriel), or estriol tripropanoate, is semisynthetic, steroidal estrogen. Estriol is a safe estrogen hormone that has been used for decades in Europe to treat hot flashes and vaginal dryness. Estriol is a major urinary estrogen. During pregnancy, large amount of estriol is produced by the placenta. Isomers with inversion of the hydroxyl group or groups are called epiestriol. Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy, it is not approved for use by the FDA or Health Canada. It is however available in the United States by prescription filled only by compounding pharmacies. It has also been approved and marketed throughout Europe and Asia for approximately 40 years for the treatment of post-menopausal hot flashes. It is an estrogen receptor agonist.
Ethamsylate (2,5-dihydroxy-benzene-sulfonate diethylammonium salt) is a synthetic hemostatic drug indicated in cases of capillary bleeding. Ethamsylate acts on the first step of hemostasis by improving platelet adhesiveness and restoring capillary resistance. In addition it inhibits prostaglandin biosynthesis. Well-controlled clinical trials clearly showed the therapeutic efficacy of ethamsylate in dysfunctional uterine bleeding, with the magnitude of blood-loss reduction being directly proportional to the severity of the menorrhagia. Other well-controlled clinical trials showed therapeutic efficacy of ethamsylate in periventricular hemorrhage in very low birth weight babies and surgical or postsurgical capillary bleeding.
Magnesite (magnesium carbonate) is a non-toxic mineral. Magnesium carbonate is an effective phosphate binder for chronic hemodialysis patients. It prevents vascular calcification in these patients. Many patients with heavily symptomatic Mitral valve prolapse syndrome have low serum magnesium, and supplementation of this ion by means of magnesium carbonate leads to improvement in most symptoms.
Status:
Possibly Marketed Outside US
Source:
Etimizol by Khromov-Borisov, N.V.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Etimizol was developed at the Institute of Experimental Medicine, St.Petersburg USSR in 1960s. Ethymisole, or 4,5-di(N-methylcarbamoyl)-1-ethyl-imidazole, is a cognitive enhancer and nootropic drug, the molecular target of which is a multifunctional protein kinase C K2 (casein kinase II). Etimizol improves short-term memory, strengthens adrenocorticotropic function of a hypophysis; excites respiratory center. It is indicated for the prevention of respiratory depression of various etiology, also etimizol is used for the treatment of astheno-depressive syndrome, arthritis, chronic obstructive pulmonary disease and bronchial asthma. Etimizol is marketed exclusively in Russia.
Status:

Class (Stereo):
CHEMICAL (ACHIRAL)



Zinc nitrate is a colorless crystalline solid. It is used as a catalyst in the manufacture of other chemicals, in medicine, and in dyes, also as a fertilizer which helps plant growth and disease resistance.
Status:
Possibly Marketed Outside US
Source:
Boarmate by Patterson, R.L.S.
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



The compound believed to be principally responsible for the unpleasant odor sometimes produced during cooking of pork or bacon from boars has been isolated and identified as 5a-androst-16-en-3-one. It is the first mammalian pheromone to be identified. Androstenone is the active ingredient in a commercial products which were developed for farmers and breeders who need help determining the best fertilization time for sows and gilts. In humans, androstenone also has been suggested to be a pheromone. Excessive exposures may affect human health, as follows: Upper respiratory tract: Irritation, Dizziness, Drowsiness, Headache, Nausea; Skin: Redness.
Status:
Possibly Marketed Outside US
Source:
Praemenstron
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)



Penflutizide ‎is a thiazide diuretic drug, Na+-Cl- symport inhibitor. Penflutizide was shown to have high potency to photooxidize lipids. Penflutizide -photosensitized peroxidation of squalene was repressed by the presence of sodium azide or 2,5-dimethylfuran and was accelerated in a D2O suspension. These findings suggest the participation of singlet oxygen in Penflutizide photoperoxidation of squalene (type II mechanism). Penflutizide -photosensitized lysis of red blood cells (RBC) accompanied by formation of hydroperoxides in RBC membrane lipids was also noted. These results suggested that membrane lipids can be one of the target molecules of Penflutizide phototoxicity. Penflutizide ‎is an ingredient of the drug Praemenstron manufactured by Nordmark Arzneimittel and consisting of Flumedroxone, Meprobamate, Penflutizide.
Fenproporex is a central and indirect-acting sympathomimetic. It was developed as an anorectic drug. Their anorectic effects are believed to be a result of adrenergic activation. Fenproporex has never been approved by the US Food and Drug Administration (FDA) for sale in the US due to lack of efficacy and safety data. There is a paucity of randomized, placebo-controlled trials on Fenproporex. These studies suggest that Fenproporex is modestly effective in promoting weight loss. Data from these studies are insufficient to determine the risk-benefit profile of Fenproporex. Abuse potential and amphetamine-like adverse effects are causes for concern. Adverse effect most frequently reported are: insomnia, anxiety, depression, irritability, dry mouth.