U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 2311 - 2320 of 2546 results

Status:
US Previously Marketed
Source:
TRIPELENNAMINE HYDROCHLORIDE by WATSON LABS
(1973)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Tripelennamine (sold as Pyribenzamine by Novartis) is a drug that is used as an antipruritic and first-generation antihistamine. Histamine acting on H1-receptors produces vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Tripelennamine can be used in the treatment of asthma, hay fever, rhinitis, and urticaria, but is now less common as newer antihistamines have replaced it.
Status:
US Previously Marketed
Source:
TRIPELENNAMINE HYDROCHLORIDE by WATSON LABS
(1973)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Tripelennamine (sold as Pyribenzamine by Novartis) is a drug that is used as an antipruritic and first-generation antihistamine. Histamine acting on H1-receptors produces vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Tripelennamine can be used in the treatment of asthma, hay fever, rhinitis, and urticaria, but is now less common as newer antihistamines have replaced it.
Status:
US Previously Marketed
First approved in 1945

Class (Stereo):
CHEMICAL (ACHIRAL)


Sulfabenzamide is an antibacterial/antimicrobial. Often used in conjunction with sulfathiazole and sulfacetamide (trade name - Sultrin) as a topical, intravaginal antibacterial preparation against Haemophilus (Gardnerella) vaginalis bacteria. The mode of action of SULTRIN is not completely known. Indirect effects, such as lowering the vaginal pH, may be equally important mechanisms.
Status:
US Previously Marketed
Source:
Chotbyn clihydrogen cit. by Flint
(1945)
Source URL:
First approved in 1945
Source:
Chotbyn clihydrogen cit. by Flint
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


TRICHOLINE CITRATE is indicated for the treatment and management of hepatic disorders and asthma symptoms in adults. It exerts lipotropic action in the hepatic cells. It also can lower the symptoms of asthma and reducing the pro-inflammatory and inflammatory mediators of the leukotriene pathway.
Status:
US Previously Marketed
Source:
Chotbyn clihydrogen cit. by Flint
(1945)
Source URL:
First approved in 1945
Source:
Chotbyn clihydrogen cit. by Flint
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


TRICHOLINE CITRATE is indicated for the treatment and management of hepatic disorders and asthma symptoms in adults. It exerts lipotropic action in the hepatic cells. It also can lower the symptoms of asthma and reducing the pro-inflammatory and inflammatory mediators of the leukotriene pathway.
Tubocurarine, a naturally occurring alkaloid, is used to treat smoking withdrawl syndrom. Tubocurarine, the chief alkaloid in tobacco products, binds stereo-selectively to nicotinic-cholinergic receptors at the autonomic ganglia, in the adrenal medulla, at neuromuscular junctions, and in the brain. Two types of central nervous system effects are believed to be the basis of Tubocurarine's positively reinforcing properties. A stimulating effect is exerted mainly in the cortex via the locus ceruleus and a reward effect is exerted in the limbic system. At low doses the stimulant effects predominate while at high doses the reward effects predominate. Intermittent intravenous administration of Tubocurarine activates neurohormonal pathways, releasing acetylcholine, norepinephrine, dopamine, serotonin, vasopressin, beta-endorphin, growth hormone, and ACTH. Tubocurarine competes with acetylcholine for post-synaptic nicotinic NM receptors and blocks them.
Tubocurarine, a naturally occurring alkaloid, is used to treat smoking withdrawl syndrom. Tubocurarine, the chief alkaloid in tobacco products, binds stereo-selectively to nicotinic-cholinergic receptors at the autonomic ganglia, in the adrenal medulla, at neuromuscular junctions, and in the brain. Two types of central nervous system effects are believed to be the basis of Tubocurarine's positively reinforcing properties. A stimulating effect is exerted mainly in the cortex via the locus ceruleus and a reward effect is exerted in the limbic system. At low doses the stimulant effects predominate while at high doses the reward effects predominate. Intermittent intravenous administration of Tubocurarine activates neurohormonal pathways, releasing acetylcholine, norepinephrine, dopamine, serotonin, vasopressin, beta-endorphin, growth hormone, and ACTH. Tubocurarine competes with acetylcholine for post-synaptic nicotinic NM receptors and blocks them.
Status:
US Previously Marketed
Source:
Vonedrine hydrochloride by Merrell (MerrellNational)
(1943)
Source URL:
First approved in 1943
Source:
Vonedrine hydrochloride by Merrell (MerrellNational)
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Phenpromethamine is an adrenergic agent. Phenpromethamine was used as vasodilator agent. It is a stimulant which is banned in sport. It is available in supplements which are sold as fat burners or pre-workout boosters. Phenpromethamine is a potent CYP2D6 inhibitor.
Status:
US Previously Marketed
Source:
Emko Foam by Endo
(1959)
Source URL:
First approved in 1942
Source:
Phemerol Chloride by Parke-Davis
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Benzethonium chloride, also known as hyamine, is a synthetic quaternary ammonium salt. It has surfactant, antiseptic, and anti-infective properties and it is used as a topical antimicrobial agent in first aid antiseptics. It is also found in cosmetics and toiletries such as mouthwashes, anti-itch ointments, and antibacterial moist towelettes. Benzethonium chloride exhibits a broad spectrum of microbiocidal activity against bacteria, fungi, mold and viruses. The US Food and Drug Administration (FDA) specifies that the safe and effective concentrations for benzethonium chloride are 0.1-0.2% in first aid products. Aqueous solutions of benzethonium chloride are not absorbed through the skin. It is not approved in the US or Europe for use as a food additive. Being a quaternary ammonium salt, it is more toxic than negatively charged surfactants. However, in a two-year study on rats, there was no evidence of carcinogenic activity. Benzethonium chloride was characterized as a novel anticancer compound possessing both in vitro and in vivo efficacy justifying further investigation.
Status:
US Previously Marketed
Source:
Emko Foam by Endo
(1959)
Source URL:
First approved in 1942
Source:
Phemerol Chloride by Parke-Davis
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Benzethonium chloride, also known as hyamine, is a synthetic quaternary ammonium salt. It has surfactant, antiseptic, and anti-infective properties and it is used as a topical antimicrobial agent in first aid antiseptics. It is also found in cosmetics and toiletries such as mouthwashes, anti-itch ointments, and antibacterial moist towelettes. Benzethonium chloride exhibits a broad spectrum of microbiocidal activity against bacteria, fungi, mold and viruses. The US Food and Drug Administration (FDA) specifies that the safe and effective concentrations for benzethonium chloride are 0.1-0.2% in first aid products. Aqueous solutions of benzethonium chloride are not absorbed through the skin. It is not approved in the US or Europe for use as a food additive. Being a quaternary ammonium salt, it is more toxic than negatively charged surfactants. However, in a two-year study on rats, there was no evidence of carcinogenic activity. Benzethonium chloride was characterized as a novel anticancer compound possessing both in vitro and in vivo efficacy justifying further investigation.

Showing 2311 - 2320 of 2546 results