U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 1 - 10 of 20 results

Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)



Erucic acid is a monounsaturated omega-9 fatty acid found mainly in the Brassica family of plants such as canola, rapeseed, wallflower seed, mustard seed as well as Brussels spouts and broccoli. Erucic acid has many of the same uses as mineral oils but with the advantage that it is more readily biodegradable. Its high tolerance to temperature makes it suitable for transmission oil. Its ability to polymerize and dry means it can be - and is - used as a binder for oil paints. Increased levels of eicosenoic acid (20:ln9) and erucic acid (22:1n9) have been found in the red blood cell membranes of autistic subjects with developmental regression. While studies done on laboratory animals in the early 1970s show that erucic acid appears to have toxic effects on the heart at high enough doses, an association between the consumption of rapeseed oil and increased myocardial lipidosis, or heart disease, has not been established for humans. While there are reports of toxicity from long-term use of Lorenzo's oil (which contains erucic acid and other ingredients), there are no reports of harm to people from dietary consumption of erucic acid. In 2003, Food Standards Australia set a provisional tolerable daily intake (PTDI) for an average adult of about 500 mg/day of erucic acid, extrapolated based on "the level that is associated with increased myocardial lipidosis in nursing pigs."
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
US Previously Marketed
Source:
21 CFR 310.545(a)(7) dandruff cresol, saponated
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


p-cresol, also known as also 4-methylphenol, is a unique bacterial metabolite from protein fermentation that is not produced by human enzymes, this metabolites has been frequently used to assess the degree of proteolytic fermentation. Recently investigation showed that p-cresol measurements might help to predict cardiovascular disease risk in renal patients over a wide range of residual renal function, beyond traditional markers of glomerular filtration. In addition, there were studies, which revealed, that urinary p-cresol was elevated in young French children with autism spectrum disorder.
Status:
US Previously Marketed
Source:
21 CFR 310.545(a)(18)(i)(B) skin protectant:w/ sales less than $25,000 stearyl alcohol
Source URL:
First approved in 1970

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Stearyl Alcohol is long chain fatty alcohol. Stearyl alcohol is prepared from stearic acid or some fats by the process of catalytic hydrogenation. It has low toxicity. Stearyl Alcohol is used in surface-active agents, lubricants, emulsions, resins, and USP ointments and as a substitute for cetyl alcohol and antifoaming agents. Stearyl Alcohol (synthetic) has been approved as a direct food additive (DFA) ingredient, to be used under the same manufacturing practices as the natrual alcohol product. It also has indirect food additive (IFA) status for use in food containers. Stearyl Alcohol is also used as an ingredient in over-the-counter (OTC) drugs of the miscellaneous external drug product category. It is considered to be safe at a concentration of 8 percent or less. Stearyl Alcohol is used in cosmetics as an emollient, stabilizer, antifoaming agent, emulsifier, and carrier. It is used as a water in oil (w/o) emulsifier to produce firm cosmetic products at ordinary temperatures.
Status:
US Previously Marketed
Source:
Pellar by Crookes-Barnes (Cooper)
(1960)
Source URL:
First approved in 1960
Source:
Pellar by Crookes-Barnes (Cooper)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Pelargonic acid (also called as nonanoic acid), a naturally found in a variety of plants and food products is a cosmetic ingredient, that function as skin-conditioning agent. The Food and Drug Administration (FDA) has approved pelargonic acid as a food additive, and as an ingredient in solutions used commercially to peel fruits and vegetables. FDA considers it safe for humans to eat food containing small amounts of pelargonic acid.
Status:
Possibly Marketed Outside US
First approved in 2023

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Showing 1 - 10 of 20 results