Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C18H38O |
| Molecular Weight | 270.4937 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCCCCCCCCCCCCCCCO
InChI
InChIKey=GLDOVTGHNKAZLK-UHFFFAOYSA-N
InChI=1S/C18H38O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19/h19H,2-18H2,1H3
| Molecular Formula | C18H38O |
| Molecular Weight | 270.4937 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: description was created based on several sources, including
https://www.truthinaging.com/ingredients/stearyl-alcohol
http://www.cosmeticsinfo.org/ingredient/stearyl-alcohol
Curator's Comment: description was created based on several sources, including
https://www.truthinaging.com/ingredients/stearyl-alcohol
http://www.cosmeticsinfo.org/ingredient/stearyl-alcohol
Stearyl Alcohol is long chain fatty alcohol. Stearyl alcohol is prepared from stearic acid or some fats by the process of catalytic hydrogenation. It has low toxicity. Stearyl Alcohol is used in surface-active agents, lubricants, emulsions, resins, and USP ointments and as a substitute for cetyl alcohol and antifoaming agents. Stearyl Alcohol (synthetic) has been approved as a direct food additive (DFA) ingredient, to be used under the same manufacturing practices as the natrual alcohol product. It also has indirect food additive (IFA) status for use in food containers. Stearyl Alcohol is also used as an ingredient in over-the-counter (OTC) drugs of the miscellaneous external drug product category. It is considered to be safe at a concentration of 8 percent or less. Stearyl Alcohol is used in cosmetics as an emollient, stabilizer, antifoaming agent, emulsifier, and carrier. It is used as a water in oil (w/o) emulsifier to produce firm cosmetic products at ordinary temperatures.
Approval Year
Doses
| Dose | Population | Adverse events |
|---|---|---|
multiple, topical (unknown) Route: topical Route: multiple Sources: |
unhealthy, 24 years Health Status: unhealthy Condition: chronic psoriasis Age Group: 24 years Sex: F Sources: |
Disc. AE: Contact dermatitis... AEs leading to discontinuation/dose reduction: Contact dermatitis Sources: |
AEs
| AE | Significance | Dose | Population |
|---|---|---|---|
| Contact dermatitis | Disc. AE | multiple, topical (unknown) Route: topical Route: multiple Sources: |
unhealthy, 24 years Health Status: unhealthy Condition: chronic psoriasis Age Group: 24 years Sex: F Sources: |
PubMed
| Title | Date | PubMed |
|---|---|---|
| The scent of senescence: age-dependent changes in the composition of the cephalic gland secretion of the male European beewolf, Philanthus triangulum. | 2006 |
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| Self-assembled two-dimensional ordered arrays of tripod-type molecules on graphite. | 2006 Jul 4 |
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| Semifluorinated chains at the air/water interface: studies of the interaction of a semifluorinated alkane with fluorinated alcohols in mixed langmuir monolayers. | 2006 Mar 14 |
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| Characterization of mixed alcohol monolayers adsorbed onto a Au(111) electrode using electro-fluorescence microscopy. | 2006 May 9 |
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| Progress in characterization of Langmuir monolayers by consideration of compressibility. | 2006 Nov 30 |
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| Theophylline granule formulation prepared by the wet granulation method: comparison of in vitro dissolution profiles and estimation of in vivo plasma concentrations. | 2006 Oct-Dec |
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| Comedogenicity in rabbit: some cosmetic ingredients/vehicles. | 2007 |
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| The oxorhenium(VII)-catalyzed direct condensation of phosphoric acid with an alcohol. | 2007 |
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| Effect of substituent position in coumarin derivatives on the interfacial assembly: reversible photodimerization and supramolecular chirality. | 2007 Feb 13 |
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| Identification of minor sex pheromone components of the poplar clearwing moth Paranthrene tabaniformis (Lepidoptera, Sesiidae). | 2007 Jan-Feb |
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| Photoimages and the release characteristics of lipophilic matrix tablets containing highly water-soluble potassium citrate with high drug loadings. | 2007 Jul 18 |
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| Langmuir and Langmuir-Blodgett films of N-(4-octadecyloxy-2-hydroxybenzylidene) derivatives of amino acids. | 2007 Jun 1 |
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| Generation and characterization of surface layers on acoustically levitated drops. | 2007 Jun 15 |
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| Formation of wormlike aggregates of fluorocarbon-hydrocarbon hybrid surfactant by Langmuir-Blodgett transfer and alignment of gold nanoparticles. | 2007 May 22 |
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| A novel flow reactor for studying reactions on liquid surfaces coated by organic monolayers: methods, validation, and initial results. | 2007 Nov 1 |
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| The effect of ethanol on the release of opioids from oral prolonged-release preparations. | 2007 Oct |
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| The odor of origin: kinship and geographical distance are reflected in the marking pheromone of male beewolves (Philanthus triangulum F., Hymenoptera, Crabronidae). | 2007 Oct 10 |
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| Wax-incorporated emulsion gel beads of calcium pectinate for intragastric floating drug delivery. | 2008 |
|
| Chemical composition and antimicrobial activity of volatile components from capitula and aerial parts of Rhaponticum acaule DC growing wild in Tunisia. | 2008 |
|
| [Research on chemical constituents from stem of Gymnema sylvestre]. | 2008 Aug |
|
| Nanotemplate-engineered nanoparticles containing gadolinium for magnetic resonance imaging of tumors. | 2008 Feb |
|
| Abnormal fatty alcohol metabolism in cultured keratinocytes from patients with Sjögren-Larsson syndrome. | 2008 Feb |
|
| [Study on preparation of phenols gastric floating tablet]. | 2008 Jan |
|
| Does the solid-liquid crystal phase transition provoke the spin-state change in spin-crossover metallomesogens? | 2008 Jan 30 |
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| Shape-persistent macrocycles with intraannular alkyl groups: some structural limits of discotic liquid crystals with an inverted structure. | 2008 Jan 9 |
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| Rumen bypass and biodistribution of l-carnitine from dual-layered coated pellets in cows, in vitro and in vivo. | 2008 Jul 9 |
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| Sustained-release pellets prepared by combination of wax matrices and double-layer coatings for extremely water-soluble drugs. | 2008 Jun |
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| Novel molecular precursor of lanthanide complexes with long chain mono cis-butene dicarboxylate to the controlled synthesis of Y2O3:Eu3+ phosphors. | 2008 Mar |
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| Reactive uptake of N2O5 on aqueous H2SO4 solutions coated with 1-component and 2-component monolayers. | 2008 May 22 |
|
| Stability enhancement effect of normal long-chain alcohols on ion pair amphiphile monolayers at the air/water interface. | 2008 Nov 15 |
|
| In situ observation of gamma-Fe2O3 nanoparticle adsorption under different monolayers at the air/water interface. | 2008 Nov 18 |
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| Development of low cost pulmonary surfactants composed of a mixture of lipids or lipids-peptides using higher aliphatic alcohol or soy lecithin. | 2008 Oct 15 |
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| Axisymmetric drop shape analysis-constrained sessile drop (ADSA-CSD): a film balance technique for high collapse pressures. | 2008 Oct 7 |
|
| Major sex pheromone components of the Australian gum leaf skeletonizer Uraba lugens: (10E,12Z)-hexadecadien-1-yl acetate and (10E,12Z)-hexadecadien-1-ol. | 2008 Sep |
|
| Syntheses, phase behavior, supramolecular chirality, and field-effect carrier mobility of asymmetrically end-capped mesogenic oligothiophenes. | 2009 |
|
| Solid lipid nanoparticles for topical administration of Kaempferia parviflora extracts. | 2009 Apr |
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| The influence of bilayer composition on the gel to liquid crystalline transition. | 2009 Aug 6 |
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| Factors controlling the stability of a kinetically hindered lamellar-lamellar transition. | 2009 Feb 19 |
|
| Comparison of age-dependent quantitative changes in the male labial gland secretion of Bombus terrestris and Bombus lucorum. | 2009 Jun |
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| Phosphonium labeling for increasing metabolomic coverage of neutral lipids using electrospray ionization mass spectrometry. | 2009 Jun |
|
| Self-assembly of alkoxy-substituted bis(hydrazone)-based organic ligands and of a metallosupramolecular grid on graphite. | 2009 Mar 9 |
|
| Allergic contact dermatitis from dichlorobenzyl alcohol in a patient with multiple contact allergies. | 2009 May |
|
| [Improvement of a sedimentation method for measuring dispersion of fibres from asbestos cement roofs]. | 2009 May-Jun |
|
| In vitro study of antibacterial activity on multi-resistant bacteria and chemical composition of the chloroform extract of endemic Centaurea drabifolia subsp. cappadocica. | 2009 Sep |
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| Synthesis of novel asymmetric zinc (II) phthalocyanines bearing octadecyloxyl and glucosyl groups. | 2009 Sep 18 |
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| Star-shaped azomethines based on tris(2-aminoethyl)amine. Characterization, thermal and optical study. | 2010 Feb |
|
| Simple and rapid analytical method for the simultaneous determination of cetrimonium chloride and alkyl alcohols in hair conditioners. | 2010 Feb |
|
| Fluorinated vs hydrogenated surfactants in mixtures with valinomycin--the Langmuir monolayer study. | 2010 Jun 1 |
|
| Monolayer structure and evaporation resistance: a molecular dynamics study of octadecanol on water. | 2010 Mar 25 |
|
| In vitro drug release mechanism from lipid nanocapsules (LNC). | 2010 May 10 |
Patents
Sample Use Guides
Stearyl alcohol induced expression of several secretory proteins including lipase, haemolysin-coregulated protein and nucleoside diphosphate kinase. Expression of these secreted proteins was upregulated at the transcriptional level. Stearyl alcohol also induced the synthesis of polyhydroxyalkanoate. Secretory protein EliA was required for all these responses of NT80 cells to stearyl alcohol.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:09:44 UTC 2023
by
admin
on
Fri Dec 15 15:09:44 UTC 2023
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| Record UNII |
2KR89I4H1Y
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| Record Status |
Validated (UNII)
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| Record Version |
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| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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NCI_THESAURUS |
C83486
Created by
admin on Fri Dec 15 15:09:44 UTC 2023 , Edited by admin on Fri Dec 15 15:09:44 UTC 2023
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| Code System | Code | Type | Description | ||
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C76735
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1082
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m10202
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37071
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DTXSID8026935
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70
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100000078780
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SUB12598MIG
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5379
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C009316
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CHEMBL24640
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32154
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204-017-6
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8221
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STEARYL ALCOHOL
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2KR89I4H1Y
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1622000
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2KR89I4H1Y
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112-92-5
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> CONSTITUENT ALWAYS PRESENT |
0.2% of chemical composition of the leaf essential oil from Moringa oleifera.
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
