STEARYL ALCOHOL

US Previously Marketed

First approved in 1970

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H38O
Molecular Weight	270.4937
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCCCCCCCCCCCCCCO

InChI

InChIKey=GLDOVTGHNKAZLK-UHFFFAOYSA-N

InChI=1S/C18H38O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19/h19H,2-18H2,1H3

HIDE SMILES / InChI

Molecular Formula	C18H38O
Molecular Weight	270.4937
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.cir-safety.org/sites/default/files/115_buff3b_suppl.pdf
Curator's Comment: description was created based on several sources, including https://www.truthinaging.com/ingredients/stearyl-alcohol http://www.cosmeticsinfo.org/ingredient/stearyl-alcohol

Stearyl Alcohol is long chain fatty alcohol. Stearyl alcohol is prepared from stearic acid or some fats by the process of catalytic hydrogenation. It has low toxicity. Stearyl Alcohol is used in surface-active agents, lubricants, emulsions, resins, and USP ointments and as a substitute for cetyl alcohol and antifoaming agents. Stearyl Alcohol (synthetic) has been approved as a direct food additive (DFA) ingredient, to be used under the same manufacturing practices as the natrual alcohol product. It also has indirect food additive (IFA) status for use in food containers. Stearyl Alcohol is also used as an ingredient in over-the-counter (OTC) drugs of the miscellaneous external drug product category. It is considered to be safe at a concentration of 8 percent or less. Stearyl Alcohol is used in cosmetics as an emollient, stabilizer, antifoaming agent, emulsifier, and carrier. It is used as a water in oil (w/o) emulsifier to produce firm cosmetic products at ordinary temperatures.

CNS Activity

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
SUNBURN 11 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0430bf68-ee36-4762-a245-ec280cb480a5	Inactive ingredient		Approved 8583	SAFETY BLANKET Approved Use USE HELPS PROTECT AGAINST SUNBURN

Doses

Dose	Population	Adverse events
multiple, topical Route: topical Route: multiple Sources: https://pubmed.ncbi.nlm.nih.gov/233882 https://pubmed.ncbi.nlm.nih.gov/33759209	unhealthy, 24 years Health Status: unhealthy Age Group: 24 years Sex: F Sources: https://pubmed.ncbi.nlm.nih.gov/233882 https://pubmed.ncbi.nlm.nih.gov/33759209	Disc. AE: Contact dermatitis... AEs leading to discontinuation/dose reduction: Contact dermatitis Sources: https://pubmed.ncbi.nlm.nih.gov/233882 https://pubmed.ncbi.nlm.nih.gov/33759209

AEs

AE	Significance	Dose	Population
Contact dermatitis	Disc. AE	multiple, topical Route: topical Route: multiple Sources: https://pubmed.ncbi.nlm.nih.gov/233882 https://pubmed.ncbi.nlm.nih.gov/33759209	unhealthy, 24 years Health Status: unhealthy Age Group: 24 years Sex: F Sources: https://pubmed.ncbi.nlm.nih.gov/233882 https://pubmed.ncbi.nlm.nih.gov/33759209

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY506981	https://www.001chemical.com/chem/112-92-5
3B Scientific (Wuhan) Corp	3B3-033578	http://www.3bsc.com/index/pro_info.php?id=55443
AA Blocks	AA0032QY	http://www.aablocks.com/goods/Goods/detail?id=AA0032QY
Aaron Chemicals	AR0033IQ	http://www.aaronchem.com/112-92-5
abcr GmbH	AB118319	http://www.abcr.com/shop/en/AB118319
Acadechem	ACDS-021059	http://www.acadechemical.com/product/95758
Achemica	ACMC-1BY8M	http://www.achemica.com/prodinfo/?id=74673
Achemtek	0102-023010	http://www.achemtek.com/112-92-5
Acros Organics	AC129300010	https://www.fishersci.com/shop/products/1-octadecanol-95-acros-organics/AC129300010
Acros Organics	AC129300025	https://www.fishersci.com/shop/products/1-octadecanol-95-acros-organics-1/AC129300025
AEchem Scientific Corp., USA	AE022785	http://www.aechemsc.com/info_products/AE022785.php
AHH Chemical co.,ltd	MT-57444	http://www.ahhchemical.com/product/MT-57444.html
AK Scientific, Inc. (AKSCI)	71510	http://www.aksci.com/item_detail.php?cat=71510
Alfa Aesar	A12020	https://www.alfa.com/en/catalog/A12020/
Alfa Chemistry	26762-44-7	https://www.alfa-chemistry.com/cas_26762-44-7.htm
Alfa Chemistry	ACM112925	https://lipids.alfa-chemistry.com/product/octadecanol-cas-112-92-5-304577.html
Alfa Chemistry	AP112925-A	https://reagents.alfa-chemistry.com/product/stearyl-alcohol-cas-112-92-5-1902.html
Alfa Chemistry	AP112925-B	https://reagents.alfa-chemistry.com/product/stearyl-alcohol-cas-112-92-5-1903.html
Alichem	490019041	http://www.alichem.com/en/products/112-92-5.html
Angene	AGN-PC-00TQ0E	http://www.angenechemical.com/productshow/AGN-PC-00TQ0E.html
Anward	ANW-16545	http://www.anward.com/pro_result/2812
Ark Pharm	AK114210	http://www.arkpharminc.com/products/112-92-5.html
BioSynth	J-002873	https://www.biosynth.com/en/products/all-products/products/J-002873.html
BLD Pharm	BD17593	http://www.bldpharm.com/products/112-92-5.html
BLD Pharm	BD59944	http://www.bldpharm.com/products/26762-44-7.html
BOC Sciences	204259-62-1	https://www.bocsci.com/1-octadecan-1-1-2-2-3-3-4-4-5-5-6-6-7-7-8-8-9-9-10-10-11-11-cas-204259-62-1-item-57055.html
Chem Scene	CS-D1671	http://www.chemscene.com/112-92-5.html
Chemenu	CM115947	http://www.chemenu.com/products/CM115947
ChemFaces	CFN90938	http://www.chemfaces.com/natural/1-Octacosanol-CFN90938.html
ChemMol	49415502	http://www.chemmol.com/chemmol/49415502.html
ChemMol	99162728	http://www.chemmol.com/chemmol/99162728.html
Chemspace	CSSB00000067537	https://chem-space.com/CSSB00000067537
Clearsynth	CS-EB-02008	https://www.clearsynth.com/en/CSEB02008.html
Clearsynth	CS-ER-02000	https://www.clearsynth.com/en/CSER02000.html
CSNpharm	CSN25402	https://www.csnpharm.com/products/1-hydroxyoctadecane.html
DC Chemicals	DC36991	http://www.dcchemicals.com//product_show-Stearyl_alcohol.html
eNovation Chemicals	D383104	http://www.enovationchem.com/productDetails.asp?productID=D383104
eNovation Chemicals	Y1081630	https://www.enovationchem.com/ProductDetails.asp?ProductID=Y1081630
Finetech	FT-0761208	http://www.finetechnology-ind.com/prod/detail/pub/112-92-5.html
Glentham Life Sciences	GK7991	http://www.glentham.com/products/product/GK7991/
Hairui	HR137527	http://www.hairuichem.com/en/product/112-92-5.html
iChemical	EBD1107	http://www.ichemical.com/chemicals/cas-112-92-5
Lab Network	LN00201746	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00201746
LGC Standards	DRE-C15710300	https://www.lgcstandards.com/US/en/p/DRE-C15710300
Matrix Scientific	99036	https://www.matrixscientific.com/099036.html
mcule	MCULE-4390437415	https://mcule.com/MCULE-4390437415/
MedChem Express	HY-Y1809	https://www.medchemexpress.com/1-hydroxyoctadecane.html
Molcore	MC506981	https://www.molcore.com/product/112-92-5
Oakwood	240948	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=121947&ExtHyperLink=1
Parchem	1707	http://www.parchem.com/chemical-supplier-distributor/Stearyl-Alcohol-003202.aspx
Sigma-Aldrich	1622000_USP	https://www.sigmaaldrich.com/catalog/product/usp/1622000?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	258768_ALDRICH	https://www.sigmaaldrich.com/catalog/product/aldrich/258768?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	346209_ALDRICH	https://www.sigmaaldrich.com/catalog/product/aldrich/346209?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	74720_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/74720?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	74723_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/74723?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sinfoo Biotech	S005402	http://www.sinfoobiotech.com/product/1008800
Smolecule	S543948	http://www.smolecule.com/products/s543948
TCI (Tokyo Chemical Industry)	O0006	http://www.tcichemicals.com/eshop/en/us/commodity/O0006/index.html
THE BioTek	bt-285041	https://www.thebiotek.com/product/inhibitors/bt-285041
Vitas-M Laboratory	STL453659	http://www.request.vitasmlab.com/index.php?option=com_search_stk&Itemid=22&stk=STL453659&?utm_source=pubchem&utm_medium=p_search_link&utm_campaign=pubchem_search&utm_content=pubchem_slink
VladaChem	VL167076	https://www.vladachem.com/product.php?products=112-92-5
Yuhao Chemical	HL1423	http://www.chemyuhao.com/112-92-5.html

PubMed

Title	Date	PubMed
Fluorinated vs hydrogenated surfactants in mixtures with valinomycin--the Langmuir monolayer study.	2010-06-01	20176461
In vitro drug release mechanism from lipid nanocapsules (LNC).	2010-05-10	20149853
Monolayer structure and evaporation resistance: a molecular dynamics study of octadecanol on water.	2010-03-25	20199042
Star-shaped azomethines based on tris(2-aminoethyl)amine. Characterization, thermal and optical study.	2010-02	20036614
Simple and rapid analytical method for the simultaneous determination of cetrimonium chloride and alkyl alcohols in hair conditioners.	2010-02	19889043
Synthesis of novel asymmetric zinc (II) phthalocyanines bearing octadecyloxyl and glucosyl groups.	2009-09-18	19783951
In vitro study of antibacterial activity on multi-resistant bacteria and chemical composition of the chloroform extract of endemic Centaurea drabifolia subsp. cappadocica.	2009-09	19831042
The influence of bilayer composition on the gel to liquid crystalline transition.	2009-08-06	19594148
[Improvement of a sedimentation method for measuring dispersion of fibres from asbestos cement roofs].	2009-07-16	19601403
Comparison of age-dependent quantitative changes in the male labial gland secretion of Bombus terrestris and Bombus lucorum.	2009-06	19543770
Phosphonium labeling for increasing metabolomic coverage of neutral lipids using electrospray ionization mass spectrometry.	2009-06	19449318
Allergic contact dermatitis from dichlorobenzyl alcohol in a patient with multiple contact allergies.	2009-05	19397627
Solid lipid nanoparticles for topical administration of Kaempferia parviflora extracts.	2009-04	20055101
Self-assembly of alkoxy-substituted bis(hydrazone)-based organic ligands and of a metallosupramolecular grid on graphite.	2009-03-09	19219889
Factors controlling the stability of a kinetically hindered lamellar-lamellar transition.	2009-02-19	19173571
Syntheses, phase behavior, supramolecular chirality, and field-effect carrier mobility of asymmetrically end-capped mesogenic oligothiophenes.	2009	19219863
In situ observation of gamma-Fe2O3 nanoparticle adsorption under different monolayers at the air/water interface.	2008-11-18	18850729
Stability enhancement effect of normal long-chain alcohols on ion pair amphiphile monolayers at the air/water interface.	2008-11-15	18786676
Development of low cost pulmonary surfactants composed of a mixture of lipids or lipids-peptides using higher aliphatic alcohol or soy lecithin.	2008-10-15	18762408
Axisymmetric drop shape analysis-constrained sessile drop (ADSA-CSD): a film balance technique for high collapse pressures.	2008-10-07	18759471
Major sex pheromone components of the Australian gum leaf skeletonizer Uraba lugens: (10E,12Z)-hexadecadien-1-yl acetate and (10E,12Z)-hexadecadien-1-ol.	2008-09	18679751
[Research on chemical constituents from stem of Gymnema sylvestre].	2008-08	19112892
Rumen bypass and biodistribution of l-carnitine from dual-layered coated pellets in cows, in vitro and in vivo.	2008-07-09	18448287
Sustained-release pellets prepared by combination of wax matrices and double-layer coatings for extremely water-soluble drugs.	2008-06	18568906
Reactive uptake of N2O5 on aqueous H2SO4 solutions coated with 1-component and 2-component monolayers.	2008-05-22	18444630
Novel molecular precursor of lanthanide complexes with long chain mono cis-butene dicarboxylate to the controlled synthesis of Y2O3:Eu3+ phosphors.	2008-03	18468122
Nanotemplate-engineered nanoparticles containing gadolinium for magnetic resonance imaging of tumors.	2008-02	18197065
Abnormal fatty alcohol metabolism in cultured keratinocytes from patients with Sjögren-Larsson syndrome.	2008-02	17971613
Does the solid-liquid crystal phase transition provoke the spin-state change in spin-crossover metallomesogens?	2008-01-30	18181626
Shape-persistent macrocycles with intraannular alkyl groups: some structural limits of discotic liquid crystals with an inverted structure.	2008-01-09	18184428
[Study on preparation of phenols gastric floating tablet].	2008-01	18338615
Wax-incorporated emulsion gel beads of calcium pectinate for intragastric floating drug delivery.	2008	18459055
Chemical composition and antimicrobial activity of volatile components from capitula and aerial parts of Rhaponticum acaule DC growing wild in Tunisia.	2008	17482441
A novel flow reactor for studying reactions on liquid surfaces coated by organic monolayers: methods, validation, and initial results.	2007-11-01	17929790
The odor of origin: kinship and geographical distance are reflected in the marking pheromone of male beewolves (Philanthus triangulum F., Hymenoptera, Crabronidae).	2007-10-10	17927833
The effect of ethanol on the release of opioids from oral prolonged-release preparations.	2007-10	17882730
Photoimages and the release characteristics of lipophilic matrix tablets containing highly water-soluble potassium citrate with high drug loadings.	2007-07-18	17532156
Generation and characterization of surface layers on acoustically levitated drops.	2007-06-15	17376468
Langmuir and Langmuir-Blodgett films of N-(4-octadecyloxy-2-hydroxybenzylidene) derivatives of amino acids.	2007-06-01	17306822
Formation of wormlike aggregates of fluorocarbon-hydrocarbon hybrid surfactant by Langmuir-Blodgett transfer and alignment of gold nanoparticles.	2007-05-22	17469862
Identification of minor sex pheromone components of the poplar clearwing moth Paranthrene tabaniformis (Lepidoptera, Sesiidae).	2007-04-12	17425119
Theophylline granule formulation prepared by the wet granulation method: comparison of in vitro dissolution profiles and estimation of in vivo plasma concentrations.	2007-02-24	17315541
Effect of substituent position in coumarin derivatives on the interfacial assembly: reversible photodimerization and supramolecular chirality.	2007-02-13	17279662
Comedogenicity in rabbit: some cosmetic ingredients/vehicles.	2007	18058303
The oxorhenium(VII)-catalyzed direct condensation of phosphoric acid with an alcohol.	2007	17226888
Design of a transdermal delivery system for aspirin as an antithrombotic drug.	2006-12-11	16949225
Progress in characterization of Langmuir monolayers by consideration of compressibility.	2006-11-30	17208192
The metabolism of fatty alcohols in lipid nanoparticles by alcohol dehydrogenase.	2006-09	16954110
Total body topical 5-fluorouracil for extensive non-melanoma skin cancer.	2006-06	17004017
The scent of senescence: age-dependent changes in the composition of the cephalic gland secretion of the male European beewolf, Philanthus triangulum.	2006	19537977

Patents

Sample Use Guides

In Vivo Use Guide

as a part of cream, losions

Route of Administration: Topical

In Vitro Use Guide

Stearyl alcohol induced expression of several secretory proteins including lipase, haemolysin-coregulated protein and nucleoside diphosphate kinase. Expression of these secreted proteins was upregulated at the transcriptional level. Stearyl alcohol also induced the synthesis of polyhydroxyalkanoate. Secretory protein EliA was required for all these responses of NT80 cells to stearyl alcohol.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:48:35 GMT 2025` Edited by `admin` on `Mon Mar 31 17:48:35 GMT 2025`
Record UNII	2KR89I4H1Y
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

OCTADECANOL

Preferred Name

English

STEARYL ALCOHOL

Official Name

English

ALFOL 18 ALCOHOL

Brand Name

English

OCTADECYL ALCOHOL

Systematic Name

English

STEARYL ALCOHOL [HSDB]

Common Name

English

SABONAL C 18 95

Brand Name

English

STEARYL ALCOHOL PC

Brand Name

English

CRODACOL S-95

Brand Name

English

STEARYL ALCOHOL [EP MONOGRAPH]

Common Name

English

STEARYL ALCOHOL 98/F

Brand Name

English

CACHALOT S-56 STEARYL ALCOHOL

Brand Name

English

Stearyl alcohol [WHO-DD]

Common Name

English

STEARYL ALCOHOL [II]

Common Name

English

LIPOCOL S-DEO

Brand Name

English

STEARYL ALCOHOL [JAN]

Common Name

English

ORISTAR SA

Brand Name

English

NSC-5379

Code

English

CRODACOL S95

Brand Name

English

TEGO ALKANOL 18

Brand Name

English

NACOL 18-98 ALCOHOL

Brand Name

English

CUSTOM STEARYL

Brand Name

English

NACOL 18-99 ALCOHOL

Brand Name

English

STEARYL ALCOHOL S

Brand Name

English

Octadecanol [WHO-DD]

Common Name

English

AEC STEARYL ALCOHOL

Brand Name

English

LIPOCOL S

Brand Name

English

STEARYL ALCOHOL 98/P

Brand Name

English

1-OCTADECANOL

Systematic Name

English

RITA SA

Brand Name

English

OCTADECENOL-

Systematic Name

English

STEARYL ALCOHOL [VANDF]

Common Name

English

STEARYL ALCOHOL [USP-RS]

Common Name

English

NACOL 18DO ALCOHOL

Brand Name

English

ALCOHOL STEARYLICUS

Common Name

English

UNIHYDAG WAX-18

Brand Name

English

STEARYL ALCOHOL [MART.]

Common Name

English

STEARYL ALCOHOL [MI]

Common Name

English

HAINOL 18SS

Brand Name

English

ULTRAPURE S

Brand Name

English

LANETTE 18

Brand Name

English

CO-1895

Brand Name

English

NIKKOL STEARYL ALCOHOL

Brand Name

English

NACOL 18-94 ALCOHOL

Brand Name

English

Classification Tree Code System Code

NCI_THESAURUS

C83486