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US Approved Rx

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DNA topoisomerase II alpha

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A673

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DNA topoisomerase II

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HepG2

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Human ovarian cancer cell line

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1974

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1979

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AIDS-related Kaposi’s sarcoma

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Glioblastoma

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Kaposi’s sarcoma

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Metastatic non-small cell lung cancer

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The Regents of The University of Colorado

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Hahn, A.|Dumaitre, P.

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Anthracyclines and related substances

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Showing 1 - 10 of 12 results

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DAUNORUBICIN

ZS7284E0ZP

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Status:

US Approved Rx (1998)

First approved in 1979

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

DNA topoisomerase I

DNA topoisomerase II alpha

Multidrug resistance-associated protein 1

Conditions:

Acute lymphoblastic leukemia

Acute myeloblastic leukemia

Daunorubicin, also known as daunomycin, is a chemotherapy medication used to treat cancer. Specifically, it is used for acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), chronic myelogenous leukemia (CML), and Kaposi's sarcoma. Similar ...

to doxorubicin, daunorubicin interacts with DNA by intercalation and inhibition of macromolecular biosynthesis. This inhibits the progression of the enzyme topoisomerase II, which relaxes supercoils in DNA for transcription. Daunorubicin stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication. On binding to DNA, daunomycin intercalates, with its daunosamine residue directed toward the minor groove. It has the highest preference for two adjacent G/C base pairs flanked on the 5' side by an A/T base pair. Daunorubicin should only be administered in a rapid intravenous infusion. It should not be administered intramuscularly or subcutaneously, since it may cause extensive tissue necrosis. It should also never be administered intrathecally (into the spinal canal), as this will cause extensive damage to the nervous system and may lead to death.

DOXORUBICIN

80168379AG

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Status:

US Approved Rx (2024)

First approved in 1974

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

DNA topoisomerase II

DNA topoisomerase II

Human ovarian cancer cell line

DNA topoisomerase II alpha

Conditions:

Locally advanced or unresectable soft tissue sarcoma

Kaposi’s sarcoma

Metastatic non-small cell lung cancer

Pancreatic ductal adenocarcinoma

AIDS-related Kaposi’s sarcoma

Multiple myeloma

Doxorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and in...

hibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Doxorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Doxorubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. Doxorubicin is used to produce regression in disseminated neoplastic conditions like acute lymphoblastic leukemia, acute myeloblastic leukemia, Wilms’ tumor, neuroblastoma, soft tissue and bone sarcomas, breast carcinoma, ovarian carcinoma, transitional cell bladder carcinoma, thyroid carcinoma, gastric carcinoma, Hodgkin’s disease, malignant lymphoma and bronchogenic carcinoma in which the small cell histologic type is the most responsive compared to other cell types. Doxorubicin is also indicated for use as a component of adjuvant therapy in women with evidence of axillary lymph node involvement following resection of primary breast cancer.

PHENYLHYDROXYLAMINE

282MU82Z9A

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

DAUNORUBICIN CITRATE

5L84T2Z6NP

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Status:

US Approved Rx (1998)

First approved in 1979

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

DNA topoisomerase I

DNA topoisomerase II alpha

Multidrug resistance-associated protein 1

Conditions:

Acute lymphoblastic leukemia

Acute myeloblastic leukemia

Daunorubicin, also known as daunomycin, is a chemotherapy medication used to treat cancer. Specifically, it is used for acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), chronic myelogenous leukemia (CML), and Kaposi's sarcoma. Similar ...

to doxorubicin, daunorubicin interacts with DNA by intercalation and inhibition of macromolecular biosynthesis. This inhibits the progression of the enzyme topoisomerase II, which relaxes supercoils in DNA for transcription. Daunorubicin stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication. On binding to DNA, daunomycin intercalates, with its daunosamine residue directed toward the minor groove. It has the highest preference for two adjacent G/C base pairs flanked on the 5' side by an A/T base pair. Daunorubicin should only be administered in a rapid intravenous infusion. It should not be administered intramuscularly or subcutaneously, since it may cause extensive tissue necrosis. It should also never be administered intrathecally (into the spinal canal), as this will cause extensive damage to the nervous system and may lead to death.

DAUNORUBICIN HYDROCHLORIDE

UD984I04LZ

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Status:

US Approved Rx (1998)

First approved in 1979

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

DNA topoisomerase I

DNA topoisomerase II alpha

Multidrug resistance-associated protein 1

Conditions:

Acute lymphoblastic leukemia

Acute myeloblastic leukemia

Daunorubicin, also known as daunomycin, is a chemotherapy medication used to treat cancer. Specifically, it is used for acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), chronic myelogenous leukemia (CML), and Kaposi's sarcoma. Similar ...

to doxorubicin, daunorubicin interacts with DNA by intercalation and inhibition of macromolecular biosynthesis. This inhibits the progression of the enzyme topoisomerase II, which relaxes supercoils in DNA for transcription. Daunorubicin stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication. On binding to DNA, daunomycin intercalates, with its daunosamine residue directed toward the minor groove. It has the highest preference for two adjacent G/C base pairs flanked on the 5' side by an A/T base pair. Daunorubicin should only be administered in a rapid intravenous infusion. It should not be administered intramuscularly or subcutaneously, since it may cause extensive tissue necrosis. It should also never be administered intrathecally (into the spinal canal), as this will cause extensive damage to the nervous system and may lead to death.

AVA-6000

7XPB9B6MUA

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Status:

US Approved Rx (2024)

First approved in 1974

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

DNA topoisomerase II

DNA topoisomerase II

Human ovarian cancer cell line

DNA topoisomerase II alpha

Conditions:

Locally advanced or unresectable soft tissue sarcoma

Kaposi’s sarcoma

Metastatic non-small cell lung cancer

Pancreatic ductal adenocarcinoma

AIDS-related Kaposi’s sarcoma

Multiple myeloma

Doxorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and in...

hibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Doxorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Doxorubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. Doxorubicin is used to produce regression in disseminated neoplastic conditions like acute lymphoblastic leukemia, acute myeloblastic leukemia, Wilms’ tumor, neuroblastoma, soft tissue and bone sarcomas, breast carcinoma, ovarian carcinoma, transitional cell bladder carcinoma, thyroid carcinoma, gastric carcinoma, Hodgkin’s disease, malignant lymphoma and bronchogenic carcinoma in which the small cell histologic type is the most responsive compared to other cell types. Doxorubicin is also indicated for use as a component of adjuvant therapy in women with evidence of axillary lymph node involvement following resection of primary breast cancer.

ZOPTARELIN DOXORUBICIN ACETATE

4IA03SIO30

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Status:

US Approved Rx (2024)

First approved in 1974

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

DNA topoisomerase II

DNA topoisomerase II

Human ovarian cancer cell line

DNA topoisomerase II alpha

Conditions:

Locally advanced or unresectable soft tissue sarcoma

Kaposi’s sarcoma

Metastatic non-small cell lung cancer

Pancreatic ductal adenocarcinoma

AIDS-related Kaposi’s sarcoma

Multiple myeloma

Doxorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and in...

hibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Doxorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Doxorubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. Doxorubicin is used to produce regression in disseminated neoplastic conditions like acute lymphoblastic leukemia, acute myeloblastic leukemia, Wilms’ tumor, neuroblastoma, soft tissue and bone sarcomas, breast carcinoma, ovarian carcinoma, transitional cell bladder carcinoma, thyroid carcinoma, gastric carcinoma, Hodgkin’s disease, malignant lymphoma and bronchogenic carcinoma in which the small cell histologic type is the most responsive compared to other cell types. Doxorubicin is also indicated for use as a component of adjuvant therapy in women with evidence of axillary lymph node involvement following resection of primary breast cancer.

DOXORUBICIN CITRATE

AJQ2ZNG2WL

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Status:

US Approved Rx (2024)

First approved in 1974

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

DNA topoisomerase II

DNA topoisomerase II

Human ovarian cancer cell line

DNA topoisomerase II alpha

Conditions:

Locally advanced or unresectable soft tissue sarcoma

Kaposi’s sarcoma

Metastatic non-small cell lung cancer

Pancreatic ductal adenocarcinoma

AIDS-related Kaposi’s sarcoma

Multiple myeloma

Doxorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and in...

hibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Doxorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Doxorubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. Doxorubicin is used to produce regression in disseminated neoplastic conditions like acute lymphoblastic leukemia, acute myeloblastic leukemia, Wilms’ tumor, neuroblastoma, soft tissue and bone sarcomas, breast carcinoma, ovarian carcinoma, transitional cell bladder carcinoma, thyroid carcinoma, gastric carcinoma, Hodgkin’s disease, malignant lymphoma and bronchogenic carcinoma in which the small cell histologic type is the most responsive compared to other cell types. Doxorubicin is also indicated for use as a component of adjuvant therapy in women with evidence of axillary lymph node involvement following resection of primary breast cancer.

ALDOXORUBICIN HYDROCHLORIDE

S098K6HGD9

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Status:

US Approved Rx (2024)

First approved in 1974

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

DNA topoisomerase II

DNA topoisomerase II

Human ovarian cancer cell line

DNA topoisomerase II alpha

Conditions:

Locally advanced or unresectable soft tissue sarcoma

Kaposi’s sarcoma

Metastatic non-small cell lung cancer

Pancreatic ductal adenocarcinoma

AIDS-related Kaposi’s sarcoma

Multiple myeloma

Doxorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and in...

hibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Doxorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Doxorubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. Doxorubicin is used to produce regression in disseminated neoplastic conditions like acute lymphoblastic leukemia, acute myeloblastic leukemia, Wilms’ tumor, neuroblastoma, soft tissue and bone sarcomas, breast carcinoma, ovarian carcinoma, transitional cell bladder carcinoma, thyroid carcinoma, gastric carcinoma, Hodgkin’s disease, malignant lymphoma and bronchogenic carcinoma in which the small cell histologic type is the most responsive compared to other cell types. Doxorubicin is also indicated for use as a component of adjuvant therapy in women with evidence of axillary lymph node involvement following resection of primary breast cancer.

ALDOXORUBICIN

C28MV4IM0B

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Status:

US Approved Rx (2024)

First approved in 1974

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

DNA topoisomerase II

DNA topoisomerase II

Human ovarian cancer cell line

DNA topoisomerase II alpha

Conditions:

Locally advanced or unresectable soft tissue sarcoma

Kaposi’s sarcoma

Metastatic non-small cell lung cancer

Pancreatic ductal adenocarcinoma

AIDS-related Kaposi’s sarcoma

Multiple myeloma

Doxorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and in...

hibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Doxorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Doxorubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. Doxorubicin is used to produce regression in disseminated neoplastic conditions like acute lymphoblastic leukemia, acute myeloblastic leukemia, Wilms’ tumor, neuroblastoma, soft tissue and bone sarcomas, breast carcinoma, ovarian carcinoma, transitional cell bladder carcinoma, thyroid carcinoma, gastric carcinoma, Hodgkin’s disease, malignant lymphoma and bronchogenic carcinoma in which the small cell histologic type is the most responsive compared to other cell types. Doxorubicin is also indicated for use as a component of adjuvant therapy in women with evidence of axillary lymph node involvement following resection of primary breast cancer.

Showing 1 - 10 of 12 results

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