PHENYLHYDROXYLAMINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H7NO
Molecular Weight	109.1259
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ONC1=CC=CC=C1

InChI

InChIKey=CKRZKMFTZCFYGB-UHFFFAOYSA-N

InChI=1S/C6H7NO/c8-7-6-4-2-1-3-5-6/h1-5,7-8H

HIDE SMILES / InChI

Molecular Formula	C6H7NO
Molecular Weight	109.1259
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Comparative nephrotoxicity of aspirin and phenacetin derivatives.	1971 Nov 27	5128205
Degradation of nitrobenzene by a Pseudomonas pseudoalcaligenes.	1993 Aug	8368838
Purification and characterization of nitrobenzene nitroreductase from Pseudomonas pseudoalcaligenes JS45.	1995 Jul	7601851
The inhibition of human cytomegalovirus (hCMV) protease by hydroxylamine derivatives.	1999 Nov 1	10560740
T cells ignore aniline, a prohapten, but respond to its reactive metabolites generated by phagocytes: possible implications for the pathogenesis of toxic oil syndrome.	2001 Apr	11304127
Interaction between dioxoruthenium(VI) porphyrins and hydroxylamines: coordination of N-substituted hydroxylamine to ruthenium and X-ray crystal structures of ruthenium complexes with a unidentate nitrosoarene ligand.	2001 Jun 1	11446633
Interdependent chemical-electrochemical steps in retrometabolism-based drug and safer chemical design.	2002 Feb	11878187
The kinetics and mechanism of the ferrate(VI) oxidation of hydroxylamines.	2003 Oct 20	14552644
Stepwise oxidation of anilines by cis-[RuIV(bpy)2(py)(O)]2+.	2004 Aug 23	15310196
Hapten-directed targeting to single-chain antibody receptors.	2004 May	15044963
Hemolytic potential of structurally related aniline halogenated hydroxylamines.	2005	15715510
Aniline derivative-induced methemoglobin in rats.	2005	15715509
Substitution and condensation reactions with poly(anilineboronic acid): reactivity and characterization of thin films.	2005 Apr 12	15807619
The hemotoxicity of para-substituted aniline analogs in dog and rat erythrocytes: a species comparison.	2005 Autumn	16315385
Genotoxic activities of aniline and its metabolites and their relationship to the carcinogenicity of aniline in the spleen of rats.	2005 Dec	16468500
Continuous synthesis of aminophenols from nitroaromatic compounds by combination of metal and biocatalyst.	2005 Jan 21	15645045
Design, synthesis and biological evaluation of sugar-derived Ras inhibitors.	2005 Oct	16196015
Computational study on the mechanism and rate constant for the C6H5 + C6H5NO reaction.	2005 Oct 13	16332011
Microdroplet dissolution into a second-phase solvent using a micropipet technique: test of the Epstein-Plesset model for an aniline-water system.	2006 Apr 25	16618164
Double-layer effects and distance dependence of electron transfer in reduction of nitro aromatic radical anions.	2006 Feb 14	16460125
Characterization of genes involved in the initial reactions of 4-chloronitrobenzene degradation in Pseudomonas putida ZWL73.	2006 Nov	16642329
A phase I study of single administration of antibody-directed enzyme prodrug therapy with the recombinant anti-carcinoembryonic antigen antibody-enzyme fusion protein MFECP1 and a bis-iodo phenol mustard prodrug.	2006 Nov 1	17085666
Coimmobilization of a redox enzyme and a cofactor regeneration system.	2006 Sep 14	17047791
Mechanistic studies of copper(I)-catalyzed allylic amination.	2007 Dec 12	18004850
Synthesis of tetra-ortho-substituted, phosphorus-containing and carbonyl-containing biaryls utilizing a Diels-Alder approach.	2007 Jul 25	17602479
Silica-immobilized enzymes for multi-step synthesis in microfluidic devices.	2007 Oct 15	17415802
An electrochemical and XPS study of reduction of nitrophenyl films covalently grafted to planar carbon surfaces.	2007 Oct 23	17900158
Mechanistic study on aniline-induced erythrocyte toxicity.	2007 Sep	17913681
Electrochemical reduction of nitrobenzene at carbon nanotube electrode.	2007 Sep 5	17374445
Transcriptome analysis of the response to chronic constant hypoxia in zebrafish hearts.	2008 Jan	17828398
Application of the PM6 method to modeling the solid state.	2008 Jun	18449579
Oriented organic islands and one-dimensional chains on a Au(111) surface fabricated by electrodeposition: an STM study.	2008 Sep 10	18710227
Detection of endocrine disrupting chemicals in aerial invertebrates at sewage treatment works.	2009 Dec	19880157
Structural modifications of quinoline-based antimalarial agents: Recent developments.	2010 Apr	21814435
Nitroreductase from Salmonella typhimurium: characterization and catalytic activity.	2010 Apr 21	20449486
Monocyclic aromatic amines as potential human carcinogens: old is new again.	2010 Jan	19887514
Clinical physiology and mechanism of dizocilpine (MK-801): electron transfer, radicals, redox metabolites and bioactivity.	2010 Jan-Feb	20716924
Eco-contribution for the production of N-arylnitrones: solvent-free and assisted by microwaves.	2010 Jun 22	20640169
Structure-activity studies on arylamides and arysulfonamides Ras inhibitors.	2010 Mar	20088786
Water--more than just a green solvent: a stereoselective one-pot access to all-chiral tetrahydronaphthalenes in aqueous media.	2010 Mar 22	20151437
Targeted LC-MS derivatization for aldehydes and carboxylic acids with a new derivatization agent 4-APEBA.	2010 May	20238107
N,O-diacyl-4-benzoyl-N-phenylhydroxylamines as photoinduced DNA cleaving agents.	2010 Sep 15	20724149

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:47:28 GMT 2023` Edited by `admin` on `Fri Dec 15 17:47:28 GMT 2023`
Record UNII	282MU82Z9A
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PHENYLHYDROXYLAMINE

Systematic Name

English

N-PHENYLHYDROXYLAMINE [HSDB]

Common Name

English

NCI-C60093

Code

English

NSC-223099

Code

English

PHENYLHYDROXYLAMINE, N-

Systematic Name

English

PHENYLHYDROXYLAMINE [MI]

Common Name

English

.BETA.-PHENYLHYDROXYLAMINE

Common Name

English

N-HYDROXYANILINE

Systematic Name

English

N-PHENYLHYDROXYLAMINE

Systematic Name

English

N-HYDROXYBENZENAMINE

Systematic Name

English

Code System Code Type Description

HSDB

2884