Inxight Drugs

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18

US Approved Rx

2

Possibly Marketed Outside US

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Primary Target

GABA receptor alpha-1 subunit

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18

0652

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2024

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Bacterial infections

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Curative

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FDA UNII

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PUBCHEM

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EPA CompTox

19

ECHA (EC/EINECS)

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Nerve depressants

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Other antiseptics and disinfectants

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Salts, Hydrates, Esters, etc.

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Showing 1 - 10 of 21 results

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Alcohol

3K9958V90M

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Status:

US Approved Rx (2018)

First marketed in 0652

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

GABA receptor alpha-1 subunit

Conditions:

Bacterial infections

Alcohols exhibit rapid broad-spectrum antimicrobial activity against vegetative bacteria (including mycobacteria), viruses, and fungi but are not sporicidal. They are, however, known to inhibit sporulation and spore germination, but this effect is re...

versible. Because of the lack of sporicidal activity, alcohols are not recommended for sterilization but are widely used for both hard-surface disinfection and skin antisepsis. Lower concentrations may also be used as preservatives and to potentiate the activity of other biocides. Many alcohol products include low levels of other biocides (in particular chlorhexidine), which remain on the skin following evaporation of the alcohol, or excipients (including emollients), which decrease the evaporation time of the alcohol and can significantly increase product efficacy. Ethanol in combination with: chlorhexidine gluconate 1% was approved to use in surgical hand antiseptic. It significantly reduces the number of microorganisms on the hands and forearms prior to surgery or patient care. Ethanol is also used as a co-solvent to dissolve many insoluble drugs and to serve as a mild sedative in some medicinal formulations. Ethanol is metabolized by the hepatic enzyme alcohol dehydrogenase. Ethanol affects the brain’s neurons in several ways. It alters their membranes as well as their ion channels, enzymes, and receptors. Alcohol also binds directly to the receptors for acetylcholine, serotonin, GABA, and the NMDA receptors for glutamate. The sedative effects of ethanol are mediated through binding to GABA receptors and glycine receptors (alpha 1 and alpha 2 subunits). It also inhibits NMDA receptor functioning. In its role as an anti-infective, ethanol acts as an osmolyte or dehydrating agent that disrupts the osmotic balance across cell membranes.

Oxalyl chloride

R4Y96317DW

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

Tetrabutylammonium

CBU2X6BBJR

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Other

Class (Stereo):

CHEMICAL (ACHIRAL)

PHENYLHYDROXYLAMINE

282MU82Z9A

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Other

Class (Stereo):

CHEMICAL (ACHIRAL)

Chloroacetyl chloride

K5UML06YUO

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

CLOMAZONE

570RAC03NF

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Status:

Possibly Marketed Outside US

First approved in 2024

Class (Stereo):

CHEMICAL (ACHIRAL)

Sodium ethanolate

1I9504387J

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Status:

US Approved Rx (2018)

First marketed in 0652

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

GABA receptor alpha-1 subunit

Conditions:

Bacterial infections

Alcohols exhibit rapid broad-spectrum antimicrobial activity against vegetative bacteria (including mycobacteria), viruses, and fungi but are not sporicidal. They are, however, known to inhibit sporulation and spore germination, but this effect is re...

versible. Because of the lack of sporicidal activity, alcohols are not recommended for sterilization but are widely used for both hard-surface disinfection and skin antisepsis. Lower concentrations may also be used as preservatives and to potentiate the activity of other biocides. Many alcohol products include low levels of other biocides (in particular chlorhexidine), which remain on the skin following evaporation of the alcohol, or excipients (including emollients), which decrease the evaporation time of the alcohol and can significantly increase product efficacy. Ethanol in combination with: chlorhexidine gluconate 1% was approved to use in surgical hand antiseptic. It significantly reduces the number of microorganisms on the hands and forearms prior to surgery or patient care. Ethanol is also used as a co-solvent to dissolve many insoluble drugs and to serve as a mild sedative in some medicinal formulations. Ethanol is metabolized by the hepatic enzyme alcohol dehydrogenase. Ethanol affects the brain’s neurons in several ways. It alters their membranes as well as their ion channels, enzymes, and receptors. Alcohol also binds directly to the receptors for acetylcholine, serotonin, GABA, and the NMDA receptors for glutamate. The sedative effects of ethanol are mediated through binding to GABA receptors and glycine receptors (alpha 1 and alpha 2 subunits). It also inhibits NMDA receptor functioning. In its role as an anti-infective, ethanol acts as an osmolyte or dehydrating agent that disrupts the osmotic balance across cell membranes.

Tetrabutylammoniumdiacetate

4J49E57WL7

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

Tetrabutylammonium fluoride trihydrate

AA4Y45K2UB

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

Tetrabutylammonium chloride

DDT9H3MSD3

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

Showing 1 - 10 of 21 results

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