FLOXACRINE, a dihydroacridinedione derivative, is an antimalarial agent. It showed high potency against blood-induced infection of drug-sensitive and drug-resistant lines of Plasmodium berghei in animal models.

Tiformin (also known as γ-Guanidinobutyramide) is a butyramide derivate with antidiabetic activity. Tiformin was isolated for the first time from a medium containing arginine which had been transformed by washed cells of Streptomyces griseus. In preclinical models, oral administration of Tiformin depresses blood glucose in rats and rabbits. Tiformin given i.v. produced hyperglycemia and sometimes death of experimental animals. Tiformin is not significantly metabolized in the rat or dog.

Cyproquinate is an anticoccidial drug, discovered by CIBA in the 1970s. Cyproquinate demonstrated marked anticoccidial activity against E. tenella infected chicks, and against a mixed coccidial infection. Cyproquinate also possessed antimalarial activity, as was demonstrated in a Novartis screen for antimalarial compounds.

Tiformin (also known as γ-Guanidinobutyramide) is a butyramide derivate with antidiabetic activity. Tiformin was isolated for the first time from a medium containing arginine which had been transformed by washed cells of Streptomyces griseus. In preclinical models, oral administration of Tiformin depresses blood glucose in rats and rabbits. Tiformin given i.v. produced hyperglycemia and sometimes death of experimental animals. Tiformin is not significantly metabolized in the rat or dog.

Pipoxizine is the antihistamine agent and antiserotonin agent. It was used as antiarrhythmic and bronchodilator.

Piprocurarium is a curarimimetic. It is antagonized by neostigmine. Piprocurarium is strongly vagolytic, producing tachicardia. Its duration of action is shorter than that of d-tubocurare and longer than that of succinylcholine. Piprocurarium is not hypotensive, is only slightly histaminogenic, is nonirritating to the veins, and can be mixed with all the anesthetic drugs. Piprocurarium has been offered for clinical trial as a brief-acting, nondepolarizing neuromuscular blocking drug. The drug appears to be anything but short acting. A persistent tachycardia and elevation in systolic and diastolic pressure invariably follows its intravenous injection. Alarming electrocardiographic changes occur, characterized by AV dissociation, depression of the ST segment, supraventricular tachycardia and, at times, inversion of the T waves. In view of these circulatory effects, it is doubtful that the drug will be useful clinically.

Deditonium is an antibacterial compound developed by the French company Centre de Recherches des Laboratoires Diamant. Deditonium is a quaternary ammonium derivative and has a bacteriostatic action at concentrations ranging from 1x10-6 to 5x10-4 M. Gram-positive cocci were found to be the most sensitive as well as many enterobacteria.

Etipirium is an antihaemorrhagic and spasmolytic drug.