FLOXACRINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C20H13ClF3NO3
Molecular Weight	407.77
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ON1C2=C(C(=O)CC(C2)C3=CC=C(C=C3)C(F)(F)F)C(=O)C4=C1C=CC(Cl)=C4

InChI

InChIKey=AWHZKKVSUJJVNL-UHFFFAOYSA-N

InChI=1S/C20H13ClF3NO3/c21-13-5-6-15-14(9-13)19(27)18-16(25(15)28)7-11(8-17(18)26)10-1-3-12(4-2-10)20(22,23)24/h1-6,9,11,28H,7-8H2

HIDE SMILES / InChI

Molecular Formula	C20H13ClF3NO3
Molecular Weight	407.77
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/117747 | https://www.ncbi.nlm.nih.gov/pubmed/1539752 | https://www.ncbi.nlm.nih.gov/pubmed/120142

FLOXACRINE, a dihydroacridinedione derivative, is an antimalarial agent. It showed high potency against blood-induced infection of drug-sensitive and drug-resistant lines of Plasmodium berghei in animal models.

Originator

Approval Year

PubMed

Title	Date	PubMed
Development of new drugs for chemoprophylaxis of malaria.	2001-07	16579068
Short report: floxacrine analog WR 243251 inhibits hematin polymerization.	2001-07	11504401
Development of new drugs for chemoprophylaxis of malaria.	2001	11584654

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:09:01 GMT 2025` Edited by `admin` on `Mon Mar 31 18:09:01 GMT 2025`
Record UNII	V09GC6329G
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

7-CHLORO-3,4-DIHYDRO-10-HYDROXY-3-(.ALPHA.,.ALPHA.,.ALPHA.-TRIFLUORO-P-TOLYL)-1,9(2H)ACRIDANDIONE

Preferred Name

English

FLOXACRINE

Official Name

English

floxacrine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C271