FLOXACRINE

Investigational

Details

Stereochemistry	RACEMIC
Molecular Formula	C20H13ClF3NO3
Molecular Weight	407.77
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

ON1C2=CC=C(Cl)C=C2C(=O)C3=C1CC(CC3=O)C4=CC=C(C=C4)C(F)(F)F

InChI

InChIKey=AWHZKKVSUJJVNL-UHFFFAOYSA-N

InChI=1S/C20H13ClF3NO3/c21-13-5-6-15-14(9-13)19(27)18-16(25(15)28)7-11(8-17(18)26)10-1-3-12(4-2-10)20(22,23)24/h1-6,9,11,28H,7-8H2

HIDE SMILES / InChI

Molecular Formula	C20H13ClF3NO3
Molecular Weight	407.77
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description

FLOXACRINE, a dihydroacridinedione derivative, is an antimalarial agent. It showed high potency against blood-induced infection of drug-sensitive and drug-resistant lines of Plasmodium berghei in animal models.

Originator

Approval Year

PubMed

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Title	Date	PubMed
Development of new drugs for chemoprophylaxis of malaria.	2001	11584654
Development of new drugs for chemoprophylaxis of malaria.	2001 Jul	16579068

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Patents

Substance Class	Chemical
Record UNII	V09GC6329G
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FLOXACRINE

Official Name

English

7-CHLORO-3,4-DIHYDRO-10-HYDROXY-3-(.ALPHA.,.ALPHA.,.ALPHA.-TRIFLUORO-P-TOLYL)-1,9(2H)ACRIDANDIONE

Common Name

English

floxacrine [INN]

Common Name

English

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Classification Tree

Code System

Code

Antiprotozoal Agent

NCI_THESAURUS

C271

Antiparasitic Agent

NCI_THESAURUS

C250

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Code System

Code

Type

Description

INN

3849

PRIMARY

PUBCHEM

68708

PRIMARY

SMS_ID

100000081021

PRIMARY

ChEMBL

CHEMBL333634

PRIMARY

EVMPD

SUB07658MIG

PRIMARY

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Related Record

Type

Details


					4Q6LXU31UA

FLOXACRINE, (S)-

ENANTIOMER -> RACEMATE


					W16K8JSG9V

FLOXACRINE, (R)-

ENANTIOMER -> RACEMATE

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Related Record

Type

Details


					V09GC6329G

FLOXACRINE

ACTIVE MOIETY

Showing 1 to 1 of 1 entries

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