Details
Stereochemistry | ACHIRAL |
Molecular Formula | C5H12N4O |
Molecular Weight | 144.175 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
NC(=N)NCCCC(N)=O
InChI
InChIKey=YHVFECVVGNXFKO-UHFFFAOYSA-N
InChI=1S/C5H12N4O/c6-4(10)2-1-3-9-5(7)8/h1-3H2,(H2,6,10)(H4,7,8,9)
Tiformin (also known as γ-Guanidinobutyramide) is a butyramide derivate with antidiabetic activity. Tiformin was isolated for the first time from a medium containing arginine which had been transformed by washed cells of Streptomyces griseus. In preclinical models, oral administration of Tiformin depresses blood glucose in rats and rabbits. Tiformin given i.v. produced hyperglycemia and sometimes death of experimental animals. Tiformin is not significantly metabolized in the rat or dog.
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Development of an in vitro cleavage assay system to examine vaccinia virus I7L cysteine proteinase activity. | 2005 Aug 16 |
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Falstatin, a cysteine protease inhibitor of Plasmodium falciparum, facilitates erythrocyte invasion. | 2006 Nov |
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Stage- and gender-specific proteomic analysis of Brugia malayi excretory-secretory products. | 2008 |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4677069
rat: 1400 mg/kg
rabbit: 800 mg/kg
Route of Administration:
Oral
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NCI_THESAURUS |
C29711
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C001316
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)