FLOXACRINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C20H13ClF3NO3
Molecular Weight	407.77
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of FLOXACRINE

Structure Search

SMILES

ON1C2=CC=C(Cl)C=C2C(=O)C3=C1CC(CC3=O)C4=CC=C(C=C4)C(F)(F)F

InChI

InChIKey=AWHZKKVSUJJVNL-UHFFFAOYSA-N

InChI=1S/C20H13ClF3NO3/c21-13-5-6-15-14(9-13)19(27)18-16(25(15)28)7-11(8-17(18)26)10-1-3-12(4-2-10)20(22,23)24/h1-6,9,11,28H,7-8H2

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/117747 | https://www.ncbi.nlm.nih.gov/pubmed/1539752 | https://www.ncbi.nlm.nih.gov/pubmed/120142

FLOXACRINE, a dihydroacridinedione derivative, is an antimalarial agent. It showed high potency against blood-induced infection of drug-sensitive and drug-resistant lines of Plasmodium berghei in animal models.

Originator

Approval Year

PubMed

PubMed

Title	Date	PubMed
Development of new drugs for chemoprophylaxis of malaria.	2001 Jul	16579068
Short report: floxacrine analog WR 243251 inhibits hematin polymerization.	2001 Jul	11504401

Patents

Patents

Name

Type

Language

FLOXACRINE

Official Name

English

7-CHLORO-3,4-DIHYDRO-10-HYDROXY-3-(.ALPHA.,.ALPHA.,.ALPHA.-TRIFLUORO-P-TOLYL)-1,9(2H)ACRIDANDIONE

Common Name

English

floxacrine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C271

Created by admin on Fri Dec 15 15:47:55 GMT 2023 , Edited by admin on Fri Dec 15 15:47:55 GMT 2023

NCI_THESAURUS

C250

Created by admin on Fri Dec 15 15:47:55 GMT 2023 , Edited by admin on Fri Dec 15 15:47:55 GMT 2023

Code System Code Type Description

INN

3849

Created by admin on Fri Dec 15 15:47:55 GMT 2023 , Edited by admin on Fri Dec 15 15:47:55 GMT 2023

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PUBCHEM

68708

Created by admin on Fri Dec 15 15:47:55 GMT 2023 , Edited by admin on Fri Dec 15 15:47:55 GMT 2023

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SMS_ID

100000081021

Created by admin on Fri Dec 15 15:47:55 GMT 2023 , Edited by admin on Fri Dec 15 15:47:55 GMT 2023

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ChEMBL

CHEMBL333634

Created by admin on Fri Dec 15 15:47:55 GMT 2023 , Edited by admin on Fri Dec 15 15:47:55 GMT 2023

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EVMPD

SUB07658MIG

Created by admin on Fri Dec 15 15:47:55 GMT 2023 , Edited by admin on Fri Dec 15 15:47:55 GMT 2023

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CAS

53966-34-0

Created by admin on Fri Dec 15 15:47:55 GMT 2023 , Edited by admin on Fri Dec 15 15:47:55 GMT 2023

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FDA UNII

V09GC6329G

Created by admin on Fri Dec 15 15:47:55 GMT 2023 , Edited by admin on Fri Dec 15 15:47:55 GMT 2023

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NCI_THESAURUS

C65701

Created by admin on Fri Dec 15 15:47:55 GMT 2023 , Edited by admin on Fri Dec 15 15:47:55 GMT 2023

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MESH

C022008

Created by admin on Fri Dec 15 15:47:55 GMT 2023 , Edited by admin on Fri Dec 15 15:47:55 GMT 2023

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EPA CompTox

DTXSID30866373

Created by admin on Fri Dec 15 15:47:55 GMT 2023 , Edited by admin on Fri Dec 15 15:47:55 GMT 2023

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ACTIVE MOIETY


					V09GC6329G