Altrenogest (INN, USAN, BAN) (brand name Regumate), also known as allyltrenbolone, is a steroidal progestin that is widely used in veterinary medicine to suppress estrus in animals. Altrenogest is an orally active progestin developed for use in the horse. Altrenogest has been chemically modified by addition of a hydroxyl group and 3 carbon chain placed on carbon 17 of the progestin. Research has demonstrated that Altrenogest has low anabolic activity and is 20 times less potent than testosterone or similar progestins when compared for effects on muscle growth in castrated rats

GLYCERYL RICINOLEATE is a monoester of glycerin and ricinoleic acid. In cosmetic formulations Glyceryl ricinoleate can have the following functions: emulsifier/co-emulsifier, refatting agent, dispersing aid. But the primary function of Glyceryl ricinoleate is a skin protection agent. Glyceryl ricinoleate is used in nearly all skin care preparations such as creams, lotions, bath oils, shaving formulations, refatting soap and shower agents in amounts of 2 – 10%. In an epicutaneous test and after long use in cosmetic preparations, no irritations were observed.

Amitraz (development code BTS27419) is a non-systemic acaricide and insecticide and has also been described as a scabicide. It was first synthesized by the Boots Co. in England in 1969. Amitraz is the only formamidine used as an ectoparasiticide. It appears to act by inhibition of the enzyme monoamine oxidase and as an agonist at octopamine receptors. Monoamine oxidase metabolizes amine neurotransmitters in ticks and mites, and octopamine is thought to modify tonic contractions in parasite muscles. Amitraz has a relatively wide safety margin in mammals; the most frequently associated adverse effect is sedation, which may be associated with an agonist activity of amitraz on α2-receptors in mammalian species. Amitraz is available as a spray or dip for use against mites, lice, and ticks in domestic livestock. It controls lice and mange in pigs and psoroptic mange in sheep. In cattle, it has been used in dips, sprays, or pour-ons for control of single-host and multihost tick species. In dipping baths, amitraz can be stabilized by the addition of calcium hydroxide and maintained by standard replenishment methods for routine tick control. An alternative method involves the use of total replenishment formulations in which the dip bath is replenished with full concentration of amitraz at weekly intervals before use. Amitraz is contraindicated in horses. Amitraz has antipyretic and antiinflammatory activity in vivo, and also has been shown to inhibit prostaglandin E2 synthesis(13). Decreased body temperature was observed in two of our cases. The basic approach to the patient with amitraz poisoning includes initial stabilization, treatment to reduce absorption and measures to improve elimination of the toxin. The medical management is essentially symptomatic and supportive. There is no specific antidote. Despite life-threatening symptomatology, all cases may recover completely. In this study we would like to emphasize that the incidence of poisoning with amitraz is increasing due to its widespread use in veterinary medicine. In order to minimize amitraz poisoning, public education should be given on primary prevention of poisoning and besides, producers should redesign containers as childproof packagers with warning labels

Linalool, ( )- is a fragrance ingredient used in decorative cosmetics, fine fragrances, shampoos, toilet soaps and other toiletries as well as in non-cosmetic products such as household cleaners and detergents. Its use worldwide is in the region of less than 0.1 metric tonnes per annum. The maximum skin level that results from the use of d-linalool in formulae that go into fine fragrances has been reported to be 0.13% assuming use of the fragrance oil at levels up to 20% in the final product. Linalool is used by pest professionals as a flea, fruit fly, and cockroach insecticide. It can also be used a method of pest control for codling moths. Linalool creates a synergistic effect with the codling moth's pheromone called codlemone, which increases the attraction of males. Linalool can be absorbed by inhalation of its aerosol and by oral intake or skin absorption, potentially causing irritation, pain and allergic reactions.

Tricetin is a dietary flavonoid found in cereals and cereal products, ginkgo nuts, pulses, and tea. It has demonstrated anti-inflammatory and anticancer effects in a number of in vitro model.

METABISULFITE ION is a food additive, also known as E-224. It is used as the preservative in processed fruit products including dried fruits, juices, and wine.

p-Chlorocresol (p-chloro-m-cresol; PCMC; brand name: Preventol CMK) possesses disinfectant and antiseptic properties. Chlorocresol is used in various preparations for skin disinfection and wounds. It also used as a preservative in creams and other preparations for external use which contain water. For use as a disinfectant such as a hand wash, it is commonly dissolved in alcohol in combination with other phenols. It is a moderate allergen for sensitive skin. Chlorocresol produces potentially life-threatening effects which include dermatitis, which are responsible for the discontinuation of chlorocresol therapy. The symptomatic adverse reactions produced by chlorocresol are more or less tolerable and if they become severe, they can be treated symptomatically, these include hypersensitivity reactions, irritation of eyes.

D&C Yellow No. 6 is an excipient (pharmacologically inactive substance). D&C Yellow No. 6 is a color additive. It has been approved for use in food, drugs, and cosmetics. D&C Yellow No. 6 is chemically manufactured by diazotizing 4-aminobenzenesulfonic acid using hydrochloric acid and sodium nitrite or sulfuric acid and sodium nitrite. The diazo compound is coupled with 6-hydroxy-2-naphthalene-sulfonic acid. The dye is isolated as the sodium salt and dried. The trisodium salt of 3-hydroxy-4-[(4-sulfophenyl)azo]-2,7-naphthalenedisulfonic acid which may be blended with the principal color is prepared in the same manner except the diazo benzenesulfonic acid is coupled with 3-hydroxy-2,7-naphthalenedisulfonic acid.