SODIUM P-CHLORO-M-CRESOL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H6ClO.Na
Molecular Weight	164.565
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].CC1=CC([O-])=CC=C1Cl

InChI

InChIKey=DPHAGKRZIJHMNL-UHFFFAOYSA-M

InChI=1S/C7H7ClO.Na/c1-5-4-6(9)2-3-7(5)8;/h2-4,9H,1H3;/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula	C7H6ClO
Molecular Weight	141.575
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.medicines.ie/medicine/15385/SPC/Anbesol+Anaesthetic+Antiseptic+Oromucosal+Solution/

p-Chlorocresol (p-chloro-m-cresol; PCMC; brand name: Preventol CMK) possesses disinfectant and antiseptic properties. Chlorocresol is used in various preparations for skin disinfection and wounds. It also used as a preservative in creams and other preparations for external use which contain water. For use as a disinfectant such as a hand wash, it is commonly dissolved in alcohol in combination with other phenols. It is a moderate allergen for sensitive skin. Chlorocresol produces potentially life-threatening effects which include dermatitis, which are responsible for the discontinuation of chlorocresol therapy. The symptomatic adverse reactions produced by chlorocresol are more or less tolerable and if they become severe, they can be treated symptomatically, these include hypersensitivity reactions, irritation of eyes.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Mouth ulcers 8 Sources: http://www.medicines.ie/medicine/15385/SPC/Anbesol+Anaesthetic+Antiseptic+Oromucosal+Solution/	Curative		Basic research	Unknown Approved Use Unknown
Sore gums 2 Sources: http://www.medicines.ie/medicine/15385/SPC/Anbesol+Anaesthetic+Antiseptic+Oromucosal+Solution/	Curative		Basic research	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Detection of phenolic compounds in flow systems based on tyrosinase-modified reticulated vitreous carbon electrodes.	2001 Aug 3	18968360
Calcium release from sarcoplasmic reticulum is facilitated in human myotubes derived from carriers of the ryanodine receptor type 1 mutations Ile2182Phe and Gly2375Ala.	2003 Fall	14641996
Supramolecular structures of 2-chloro-5-methylphenol and 4-chloro-3-methylphenol (chlorocresol).	2003 Sep	12944669
Influence of intracellular Ca2+ release modulating drugs on bupivacaine infiltration anesthesia in mice.	2004 Apr	14987625
4-chloro-m-cresol cannot detect malignant hyperthermia equivocal cells in an alternative minimally invasive diagnostic test of malignant hyperthermia susceptibility.	2004 Jul	15281512
Human muscle sarcoplasmic reticulum function during submaximal exercise in normoxia and hypoxia.	2004 Jul	15220318
Functional characterization of malignant hyperthermia-associated RyR1 mutations in exon 44, using the human myotube model.	2004 Jul	15210166
Optimization by experimental design and artificial neural networks of the ion-interaction reversed-phase liquid chromatographic separation of twenty cosmetic preservatives.	2004 Mar 12	15032350
[Contact sensitization to pharmaceutic aids in dermatologic cosmetic and external use preparations].	2004 May	15218738
Role of intracellular calcium in acute thermal pain perception.	2004 Nov	15527827
Contact urticaria due to p-chloro-m-cresol.	2004 Oct	15491450
Effect of ryanodine receptor mutations on interleukin-6 release and intracellular calcium homeostasis in human myotubes from malignant hyperthermia-susceptible individuals and patients affected by central core disease.	2004 Oct 15	15299003
Temperature activated degradation (mineralization) of 4-chloro-3-methyl phenol by Fenton's reagent.	2005 Apr	15763092
Membrane-assisted solvent extraction of seven phenols combined with large volume injection-gas chromatography-mass spectrometric detection.	2005 Apr 22	15881457
Caffeine induced Ca2+ release and capacitative Ca2+ entry in human embryonic kidney (HEK293) cells.	2005 Feb 21	15733545
Enhanced response to caffeine and 4-chloro-m-cresol in malignant hyperthermia-susceptible muscle is related in part to chronically elevated resting [Ca2+]i.	2005 Mar	15537710
Simultaneous determination of phenolic compounds by means of an automated voltammetric "electronic tongue".	2005 May	15895214
Non-specific effects of 4-chloro-m-cresol may cause calcium flux and respiratory burst in human neutrophils.	2005 Nov 4	16168959
Ryanodine receptors are involved in muscarinic antinociception in mice.	2005 Nov 7	16051378
Final report on the safety assessment of sodium p-chloro-m-cresol, p-chloro-m-cresol, chlorothymol, mixed cresols, m-cresol, o-cresol, p-cresol, isopropyl cresols, thymol, o-cymen-5-ol, and carvacrol.	2006	16835130
Functional properties of ryanodine receptors carrying three amino acid substitutions identified in patients affected by multi-minicore disease and central core disease, expressed in immortalized lymphocytes.	2006 Apr 15	16372898
Effects of caffeine, halothane, and 4-chloro-m-cresol on skeletal muscle lactate and pyruvate in malignant hyperthermia-susceptible and normal swine as assessed by microdialysis.	2006 Jan	16394695
3-Methyl-4-chlorophenol for prion decontamination of medical devices.	2006 Jul	16807860
Amino acid residues Gln4020 and Lys4021 of the ryanodine receptor type 1 are required for activation by 4-chloro-m-cresol.	2006 Jul 28	16737973
Characterization of ryanodine receptor-mediated calcium release in human B cells: relevance to diagnostic testing for malignant hyperthermia.	2006 Jun	16732090
Blockade of intracellular calcium release induces an antidepressant-like effect in the mouse forced swimming test.	2006 Mar	16249008
Amperometric determination of chloroguaiacol at submicromolar levels after on-line preconcentration with molecularly imprinted polymers.	2006 Mar 15	18970563
Alterations in calcium homeostasis reduce membrane excitability in amphibian skeletal muscle.	2006 Nov	16955310
Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.	2006 Nov	16497524
[Effects of agonists and antagonists of rhyanodine receptors on potassium contractures in twitch and tonic frog skeletal muscle fibers].	2006 Sep-Oct	17131831
The Sonogel-Carbon materials as basis for development of enzyme biosensors for phenols and polyphenols monitoring: a detailed comparative study of three immobilization matrixes.	2007 Jun 15	17215118
Central core disease.	2007 May 15	17504518
Increased Ca2+ storage capacity of the skeletal muscle sarcoplasmic reticulum of transgenic mice over-expressing membrane bound calcium binding protein junctate.	2007 Nov	17516551
4-Chloro-m-cresol, an activator of ryanodine receptors, inhibits voltage-gated K(+) channels at the rat calyx of Held.	2007 Sep	17714495
Screening of 397 chemicals and development of a quantitative structure--activity relationship model for androgen receptor antagonism.	2008 Apr	18324785
Identification and biochemical characterization of a novel ryanodine receptor gene mutation associated with malignant hyperthermia.	2008 Feb	18212565
Dynamics of intracellular oxygen in PC12 Cells upon stimulation of neurotransmission.	2008 Feb 29	18086678
Faster and simpler determination of chlorophenols in water by fiber introduction mass spectrometry.	2008 Jul 14	18558129
Ryanodine receptor expression correlates with tumor grade in breast cancer.	2008 Jun	18431693
Wide-ranging genomic effects of plasticisers and related compounds.	2008 May	18473747
Functional analysis of ryanodine receptor type 1 p.R2508C mutation in exon 47.	2009	19685112
Functional characterization of ryanodine receptor (RYR1) sequence variants using a metabolic assay in immortalized B-lymphocytes.	2009 Apr	19191333
Increasing the number of diagnostic mutations in malignant hyperthermia.	2009 Apr	19191329
Use of a programmed temperature vaporizer and an in situ derivatization reaction to improve sensitivity in headspace-gas chromatography. Application to the analysis of chlorophenols in water.	2009 Feb 13	19124129
Functional ryanodine receptors in the plasma membrane of RINm5F pancreatic beta-cells.	2009 Feb 20	19116207
Altered stored calcium release in skeletal myotubes deficient of triadin and junctin.	2009 Jan	18620751
Determination of water pollutants by direct-immersion solid-phase microextraction using polymeric ionic liquid coatings.	2010 Feb 19	20044092
A ryanodine receptor agonist promotes the consolidation of long-term memory in young chicks.	2010 Jan 5	19716384
Functional properties of RYR1 mutations identified in Swedish patients with malignant hyperthermia and central core disease.	2010 Jul	20142353
Mechanism of the anodic oxidation of 4-chloro-3-methyl phenol in aqueous solution using Ti/SnO2-Sb/PbO2 electrodes.	2010 Mar 15	19914775

Patents

Sample Use Guides

In Vivo Use Guide

Apply undiluted to the affected area with the fingertip. Two applications immediately will normally be sufficient to obtain pain relief. It should not be used more frequently than every 3 hours or as directed by the physician or dentist.

Route of Administration: Dental

In Vitro Use Guide

In voltage-clamp recordings, 4-Chloro-m-cresol (4-CmC) inhibited voltage-gated presynaptic K(+) currents (I(pK)) by 53% (at +20 mV) but had no effect on voltage-gated presynaptic Ca(2+) currents (I(pCa)).

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:54:05 GMT 2023` Edited by `admin` on `Fri Dec 15 18:54:05 GMT 2023`
Record UNII	343KVA8Y38
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SODIUM P-CHLORO-M-CRESOL

Official Name

English

3-METHYL-4-CHLOROPHENOL, SODIUM SALT

Common Name

English

SODIUM P-CHLORO-M-CRESOL [INCI]

Common Name

English

PREVENTOL CMK SODIUM SALT

Common Name

English

4-CHLORO-M-CRESOL, SODIUM SALT

Common Name

English

Classification Tree Code System Code

Food Contact Sustance Notif, (FCN No.)

FCN NO. 1078