FOOD YELLOW 3 FREE ACID

First approved in 1982

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H12N2O7S2
Molecular Weight	408.406
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC1=CC=C2C=C(C=CC2=C1\N=N\C3=CC=C(C=C3)S(O)(=O)=O)S(O)(=O)=O

InChI

InChIKey=KEYWXKLGZZGHMT-ISLYRVAYSA-N

InChI=1S/C16H12N2O7S2/c19-15-8-1-10-9-13(27(23,24)25)6-7-14(10)16(15)18-17-11-2-4-12(5-3-11)26(20,21)22/h1-9,19H,(H,20,21,22)(H,23,24,25)/b18-17+

HIDE SMILES / InChI

Molecular Formula	C16H12N2O7S2
Molecular Weight	408.406
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.fda.gov/forindustry/coloradditives/coloradditiveinventories/ucm106626.htm | https://sites.google.com/a/umn.edu/phar6157s13/home/d-c-yellow-no-6 | https://www.drugs.com/inactive/d-c-yellow-no-6-343.html

D&C Yellow No. 6 is an excipient (pharmacologically inactive substance). D&C Yellow No. 6 is a color additive. It has been approved for use in food, drugs, and cosmetics. D&C Yellow No. 6 is chemically manufactured by diazotizing 4-aminobenzenesulfonic acid using hydrochloric acid and sodium nitrite or sulfuric acid and sodium nitrite. The diazo compound is coupled with 6-hydroxy-2-naphthalene-sulfonic acid. The dye is isolated as the sodium salt and dried. The trisodium salt of 3-hydroxy-4-[(4-sulfophenyl)azo]-2,7-naphthalenedisulfonic acid which may be blended with the principal color is prepared in the same manner except the diazo benzenesulfonic acid is coupled with 3-hydroxy-2,7-naphthalenedisulfonic acid.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
diaper rash 2 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=dfe6a47c-ec31-4421-877e-f953e4c99889	Inactive ingredient		Approved 8429	JOHNSONS BABY baby shampoos shampoo Approved Use helps treat and prevent diaper rash; protects chafed skin due to diaper rash and helps seal out wetness Launch Date 1.33963199E12

Sample Use Guides

In Vivo Use Guide

Acceptable daily intake of Yellow No. 6 is 3.75mg/kg/day according to the FDA

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:32:44 UTC 2023` Edited by `admin` on `Fri Dec 15 18:32:44 UTC 2023`
Record UNII	G2B7JWK1GG
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FOOD YELLOW 3 FREE ACID

Common Name

English

6-HYDROXY-5-(4-SULFOPHENYLAZO)-2-NAPHTHALENESULFONIC ACID

Systematic Name

English

2-NAPHTHALENESULFONIC ACID, 6-HYDROXY-5-)(4-SULFOPHENYL)AZO)-

Common Name

English

C.I. FOOD YELLOW 3 (FREE ACID)

Common Name

English

Code System Code Type Description

DAILYMED

G2B7JWK1GG