U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 2361 - 2370 of 12951 results

Status:
Possibly Marketed Outside US
Source:
part352
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)


Octisalate used as an ingredient in sunscreens and cosmetics. Maximum FDA-approved concentration - 5%. Range of protection - UVB. Might develop contact allergic dermatitis
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (RACEMIC)

1,2-Hexanediol is widely used in various cosmetic applications such as hair conditioners, deodorants and antiperspirants. It is involved in the modification of sodium dodecyl sulfate micelles, which is used for amino acid separation by micellar electrokinetic chromatography method. It is a moisturizing agent and plays a vital role in baby care products, bath products, eye makeup, cleansing products and skin care products. It is also used as an additive in liquid cleaning compositions. Acute and chronic toxicities of 1,2-Hexanediol were generally lower than those of methylparaben. The antimicrobial activity of 1,2-Hexanediol against Gram-positive and Gram-negative bacteria was potentiated with food-grade antimicrobials including xanthorrhizol, macelignan, panduratin A and octyl gallate, which have already been reported to display anti-inflammatory and other beneficial activities related to cosmetics. Therefore, the combination of 1,2-Hexanediol and these food-grade antimicrobial agents would have benefits not only for increasing the antimicrobial activity but also in cosmetics use.
Status:
Possibly Marketed Outside US
Source:
Canada:NICARBAZIN
Source URL:
First approved in 1993

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Nicarbazin, a complex of two compounds, 4,4'-dinitrocarbanilide (DNC) and 4,6-dimethyl-2-pyrimidinol (HDP) is an effective drug for preventing intestinal and caecal coccidiosis in poultry. It is used for prevention rather than the treatment of disease. Nicarbazin was the first agent with “broad‐spectrum” activity against Eimeria spp. of chickens. Nicarbazin is used as a single agent or in combination with polyether antibiotics (narasin, or maduramicin), roxarsone, or antibiotics (lincomycin, bacitracin, flavomycin) for prevention and control of coccidiosis caused by Eimeria spp. (all relevant species) in broiler chickens. Nicarbazin can cause increased sensitivity to heat stress, which may result in growth depression and even mortality in broilers; death may be due to cell degeneration processes in liver and kidneys; at the recommended dose, the drug causes occasionally toxic effects in laying hens like reduced hatchability and interruption of egg-laying. Nicarbazin interferes with the formation of the vitelline membrane, separating the egg yolk and egg white. The exact mode of action is unknown, although it is thought nicarbazin interferes with cholesterol metabolism in the formation of the membrane.
Status:
Possibly Marketed Outside US
Source:
UK NHS:Methoxymethane
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Dimethyl ether in combination with propane was approved to use in home conditions for the cryotherapy to treat warts. Nevertheless, this cold spray has to be used very careful not to damage unaffected areas of the skin.

Showing 2361 - 2370 of 12951 results