Details
Stereochemistry | RACEMIC |
Molecular Formula | C6H14O2 |
Molecular Weight | 118.1742 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCC(O)CO
InChI
InChIKey=FHKSXSQHXQEMOK-UHFFFAOYSA-N
InChI=1S/C6H14O2/c1-2-3-4-6(8)5-7/h6-8H,2-5H2,1H3
1,2-Hexanediol is widely used in various cosmetic applications such as hair conditioners, deodorants and antiperspirants. It is involved in the modification of sodium dodecyl sulfate micelles, which is used for amino acid separation by micellar electrokinetic chromatography method. It is a moisturizing agent and plays a vital role in baby care products, bath products, eye makeup, cleansing products and skin care products. It is also used as an additive in liquid cleaning compositions. Acute and chronic toxicities of 1,2-Hexanediol were generally lower than those of methylparaben. The antimicrobial activity of 1,2-Hexanediol against Gram-positive and Gram-negative bacteria was potentiated with food-grade antimicrobials including xanthorrhizol, macelignan, panduratin A and octyl gallate, which have already been reported to display anti-inflammatory and other beneficial activities related to cosmetics. Therefore, the combination of 1,2-Hexanediol and these food-grade antimicrobial agents would have benefits not only for increasing the antimicrobial activity but also in cosmetics use.
Approval Year
PubMed
Title | Date | PubMed |
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Inhibition of N-methyl-D-aspartate receptors by straight-chain diols: implications for the mechanism of the alcohol cutoff effect. | 2002 Jan |
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[Coprecipitation of the Pseudomonas fluorescens lipase with hydrophobic compounds as an approach to its immobilization for catalysis in nonaqueous media]. | 2002 Jan-Feb |
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Organic modifiers for the separation of organic acids and bases by liquid chromatography. | 2002 Jul 26 |
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Profiling isoflavonoids found in legume root extracts using capillary electrophoresis. | 2002 Jun |
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Stereoselective oxidation of aliphatic diols and reduction of hydroxy-ketones with galactitol dehydrogenase from Rhodobacter sphaeroides D. | 2003 |
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Influence of ion pairing on topical delivery of retinoic acid from microemulsions. | 2003 Jan 17 |
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Purification, characterization, and gene cloning of glycerol dehydrogenase from Hansenula ofunaensis, and its expression for production of optically active diol. | 2006 Dec |
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Positively charged microemulsions for topical application. | 2008 Jan 4 |
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Modification of galactitol dehydrogenase from Rhodobacter sphaeroides D for immobilization on polycrystalline gold surfaces. | 2009 Oct 20 |
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Acid-, water- and high-temperature-stable ruthenium complexes for the total catalytic deoxygenation of glycerol to propane. | 2009 Oct 5 |
Patents
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TR046Y3K1G
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TR046Y3K1G
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SUB179561
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DB14108
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100000164927
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94335
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DTXSID40863959
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1362584
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230-029-6
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6920-22-5
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SUBSTANCE RECORD