U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 741 - 750 of 2596 results

Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Conditions:

NSC-LSC1 is a novel compound having an antitumor activity belonging to an analogue of taxol. As with the taxol, the NSC-LSC1 has a low toxicity and a high antitumor activity. NSC-LSC1 exhibits a high proliferation inhibitory activity against human or animal cancer cells transplanted into a test animal and further, a low toxicity to the animal which renders NSC-LSC1 promising as a compound for use in the field of chemotherapy of cancers.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Conditions:

Norgestrel,(+) (dextronorgestrel) is the biologically inactive isomer of norgestrel. Dextronorgestrel showed no ability to displace labelled levonorgestrel from the sex hormone binding globulin sites. In vitro active form being converted mainly to the 16 beta-hydroxysteroid and inactive form to the 16 alpha-hydroxysteroid. There was practically no binding to dextronorgestrel of dextronorgestrel to a cytoplasmic receptor prepared from the myometrium of estrogenized immature female rabbits was investigated. While some medications may contain dextronorgestrel, they are often labeled in terms of their levonorgestrel content only, ignoring the inert isomer.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

2,4,5-trimethoxybenzaldehyde, also known as asaraldehyde or gazarin, belongs to benzoyl derivatives class of compounds. 2,4,5-trimethoxybenzaldehyde can be found in carrot, herbs and spices, root vegetables, and wild carrot, and is a constituent of a bitter principle of these products. 2,4,5-trimethoxybenzaldehyde is an inhibitor of cyclooxygenase 2.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Magnesium selenide is a stable, light gray to brown crystalline powder. Magnesium selenide can be prepared by reaction of magnesium oxide and selenium. Magnesium selenide is not stable in air and reacts with moisture to form Magnesium hydroxide and Hydrogen selenide. Magnesium selenide is a wide-band semiconductor but is not very stable by itself. MgSe is available commercially as a sputtering or plasma targets for preparing thin-layer electronic structures for diodes, solid-state lasers and the like.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Diethylaminosulfur trifluoride (DAST) has proven itself to be an extremely popular reagent for nucleophilic fluorination, due to its ease of handling and versatility. It has regularly been employed in a myriad selective fluorinations of alcohols, alkenols, carbohydrates, ketones, sulfides, epoxides, thioethers, and cyanohydrins. In addition some novel organic cyclizations are possible when DAST is employed as a reagent.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Cryptopine is an opium alkaloid, which was found in the highest relative concentration in F. rostellata (25.1 %), F. schrammii (17.6 %) and F. thuretii (16.3 %). Experiments on animal have shown that cryptopine disturbs the cellular defense system.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Cupric hexafluorosilicate is an inorganic chemical compound of copper from the group of hexafluorosilicates. It has being used as a Pesticide. Cupric hexafluorosilicate was used earlier as a wood preservative.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Cupric selenate is a catalyst in the Kjeldahl method for determination of nitrogen.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Ethyl β-carboline-3-carboxylate or beta-carboline-3-carboxylic acid ethyl ester, an endogenous compound that was isolated from human urine. It is a partial inverse agonist at the benzodiazepine site on the GABA-A receptor. Experiments on rats have shown that ethyl β-carboline-3-carboxylate produces the anxiogenic-like effect but do not affect brainstem activated hippocampal theta.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Protopine is the isoquinoline alkaloid found primarily in the plant families Berberidaceae, Ranunculaceae, Rutaceae, Fumariaceae. It has diverse biological activities, such as anti-thrombotic, anti-inflammatory, anti-parasitic activity, antimicrobial activity, as well as hepatoprotective effects in animal models. The biological activities of protopine are associated with its ability selectively inhibits K(ATP) channels by targeting on SUR1 subunit. In addition, was discovered that β2 -adrenoceptor (β2 -AR) is a target for antiasthma activities of protopine. On this target, binding of the drug occurs on the amino acid residual of Ser 169 through the formation of hydrogen bonds and receptor‐drug bumps.