U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C21H23NO5
Molecular Weight 369.411
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CRYPTOPINE

SMILES

COC1=CC2=C(C=C1OC)C(=O)CC3=CC=C4OCOC4=C3CN(C)CC2

InChI

InChIKey=XPOJSWHIKCNLEQ-UHFFFAOYSA-N
InChI=1S/C21H23NO5/c1-22-7-6-14-9-19(24-2)20(25-3)10-15(14)17(23)8-13-4-5-18-21(16(13)11-22)27-12-26-18/h4-5,9-10H,6-8,11-12H2,1-3H3

HIDE SMILES / InChI

Description

Cryptopine is an opium alkaloid, which was found in the highest relative concentration in F. rostellata (25.1 %), F. schrammii (17.6 %) and F. thuretii (16.3 %). Experiments on animal have shown that cryptopine disturbs the cellular defense system.

Approval Year

Unknown
139594
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
[On the companion alkaloids of morphine. 4. Identification and semi-quantitative determination of narcotoline, cryptopine, papaverine and narceine in the single phases of the Kabay procedure for preparation of morphine].
1968 Dec
Recovery of thebaine and cryptopine from Indian opium.
1980
Direct determination of alkaloid contents in Fumaria species by GC-MS.
2002 Nov-Dec
Stimulation of lipid peroxidation and impairment of glutathione-dependent defense system in Wistar rats treated with cryptopine, a rare non-narcotic opium alkaloid.
2004 Jan-Mar
Patents

Patents

20060045930
2

Sample Use Guides

In Vivo Use Guide
disturbs the cellular defense system in rats: 50, 100, 150, 200 mg/kg bwt
Route of Administration: Oral
In Vitro Use Guide
Curator's Comment: Protopine enhances 3H-gamma-aminobutyric acid (3H-GABA) binding to rat brain synaptic membrane receptors
Unknown
Name Type Language
CRYPTOPINE
MI  
Common Name English
4,6,7,13-TETRAHYDRO-9,10-DIMETHOXY-5-METHYLBENZO(G)-1,3-BENZODIOXOLO(4,5-C)AZECIN-12(5H)-ONE
Systematic Name English
CRYPTOPINE [MI]
Common Name English
CRYPTOPIN
Common Name English
NSC-32984
Code English
CRYPTOCAVINE
Common Name English
KRYPTOPINE
Common Name English
KRYPTOCAVIN
Common Name English
Code System Code Type Description
ECHA (EC/EINECS)
207-584-8
Created by admin on Sat Dec 16 04:29:04 GMT 2023 , Edited by admin on Sat Dec 16 04:29:04 GMT 2023
PRIMARY
CAS
482-74-6
Created by admin on Sat Dec 16 04:29:04 GMT 2023 , Edited by admin on Sat Dec 16 04:29:04 GMT 2023
PRIMARY
FDA UNII
MW13X5YK4A
Created by admin on Sat Dec 16 04:29:04 GMT 2023 , Edited by admin on Sat Dec 16 04:29:04 GMT 2023
PRIMARY
PUBCHEM
72616
Created by admin on Sat Dec 16 04:29:04 GMT 2023 , Edited by admin on Sat Dec 16 04:29:04 GMT 2023
PRIMARY
MERCK INDEX
m3868
Created by admin on Sat Dec 16 04:29:04 GMT 2023 , Edited by admin on Sat Dec 16 04:29:04 GMT 2023
PRIMARY Merck Index
NSC
32984
Created by admin on Sat Dec 16 04:29:04 GMT 2023 , Edited by admin on Sat Dec 16 04:29:04 GMT 2023
PRIMARY
WIKIPEDIA
Cryptopine
Created by admin on Sat Dec 16 04:29:04 GMT 2023 , Edited by admin on Sat Dec 16 04:29:04 GMT 2023
PRIMARY
EPA CompTox
DTXSID40197463
Created by admin on Sat Dec 16 04:29:04 GMT 2023 , Edited by admin on Sat Dec 16 04:29:04 GMT 2023
PRIMARY
SUBSTANCE RECORD
Structure of CRYPTOPINE
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966