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The information related to any pharmacological or biological properties of tromethamine phosphate is absent.
Fluvastatin Anti-Isomer is a metabolite of lipid-lowering agent Fluvastatin. Fluvastatin is very unstable during storage and anti-isomer as well as lactones are the main formed by-products.
Fluoroquinolonic acid is major impurity present in Fluoroquinolone Antibacterial Agents such as Enrofloxacin or ciprofloxacin
of metoclopramide. Fluoroquinolonic acid shows weak antimicrobial activity.
4-Nitro-3-trifluoromethylaniline is one of the two main products of flutamide metabolism in human liver microsomes. Also, it is a major urinary metabolite of S-1 [3-(4-fluorophenoxy)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-propanamide] - a member of a series of potent selective androgen receptor modulators.
Status:
Other
Class (Stereo):
CHEMICAL (MIXED)
Conditions:
Ro 4-1284 is a VMAT2 inhibitor. Compond exhibits reserpine-like effect and is used as a tool compound in preclinical studies, its chronic administration lead to such symptoms as deterioration of learning, decrease in locomotion in rearing, intense hypothermia
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
ASARININ, (+)- ((+)-episesamin), an abundant lignan
in sesame seed, has been identified as an active principle
in an aqueous extract of Lindera obtusiloba (Japanese
Spicebush) with a strong anti-inflammatory
potential. (+)-episesamin (ES) is known to block the TNF-α-induced mitogenic VSMC response. Protective effect of (+)-episesamin against PDGF-BB-induced activation of vascular smooth muscle cells is mediated by induction of haem oxygenase-1 and inhibition of mitogenic signalling. ES interferes with inflammation-associated VSMC activation and subsequent decreased proliferation and migration due to anti-oxidative properties and impaired activation of NF-ĸB, known contributors to atherogenesis. These results suggest ES as a complemental treatment of VSMC specific vascular diseases such as atherosclerosis. (+)-Episesamin inhibits adipogenesis and exerts anti-inflammatory effects in 3T3-L1 (pre)adipocytes by sustained Wnt signaling, down-regulation of PPARγ and induction of iNOS. (+)-episesamin seems to be the active drug in the L. obtusiloba extract being responsible for the inhibition of adipogenesis and, thus, should be evaluated as a novel potential complementary treatment for obesity.
Senegenin 2-acetate is a product obtained by acetylation of senegenin by acetic anhydride. Under alkaline conditions, acetate undergoes hydrolysis to yield senegenin.
There is a little information in the literature related to the biological and pharmacological activity of estriol triacetate. And it has never been marketed.
Ent-atorvastatin (3S,5S-atorvastatin) is impurity and inactive enantiomer of lipid-lowering agent Atorvastatin.
Fulvestrant Beta-Isomer, also known as Fulvestrant EP Impurity A. Fulvestrant, sold under the trade name Faslodex among others, is an estrogen receptor antagonist indicated for the treatment of hormone receptor (HR)-positive metastatic breast cancer in postmenopausal women with disease progression as well as HR-positive, HER2-negative advanced breast cancer in combination with palbociclib in women with disease progression after endocrine therapy.