FLUVASTATIN ANTI-ISOMER

Details

Stereochemistry	RACEMIC
Molecular Formula	C24H26FNO4
Molecular Weight	411.4659
Optical Activity	( + / - )
Defined Stereocenters	2 / 2
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)N1C(\C=C\[C@H](O)C[C@@H](O)CC(O)=O)=C(C2=C1C=CC=C2)C3=CC=C(F)C=C3

InChI

InChIKey=FJLGEFLZQAZZCD-FUTHQCHMSA-N

InChI=1S/C24H26FNO4/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30)/b12-11+/t18-,19+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C24H26FNO4
Molecular Weight	411.4659
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	1
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/19418962
Curator's Comment: The description was created based on several sources, including https://www.jstage.jst.go.jp/article/dmpk1986/10/6/10_6_779/_pdf

Fluvastatin Anti-Isomer is a metabolite of lipid-lowering agent Fluvastatin. Fluvastatin is very unstable during storage and anti-isomer as well as lactones are the main formed by-products.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
Improvement in chemical and physical stability of fluvastatin drug through hydrogen bonding interactions with different polymer matrices.	2009 Jan	19418962

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 05:33:28 UTC 2023` Edited by `admin` on `Sat Dec 16 05:33:28 UTC 2023`
Record UNII	OT7W70P7E1
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FLUVASTATIN ANTI-ISOMER

Common Name

English

(3RS,5RS,6E)-7-(3-(4-FLUOROPHENYL)-1-(1-METHYLETHYL)-1H-INDOL-2-YL)-3,5-DIHYDROXYHEPT-6-ENOIC ACID

Systematic Name

English

6-HEPTENOIC ACID, 7-(3-(4-FLUOROPHENYL)-1-(1-METHYLETHYL)-1H-INDOL-2-YL)-3,5-DIHYDROXY-, (3R,5R,6E)-REL-

Common Name

English

FLUVASTATIN SODIUM IMPURITY A [EP IMPURITY]

Common Name

English

Code System Code Type Description

FDA UNII

OT7W70P7E1

Created by admin on Sat Dec 16 05:33:28 UTC 2023 , Edited by admin on Sat Dec 16 05:33:28 UTC 2023

PRIMARY

CAS

174956-43-5

Created by admin on Sat Dec 16 05:33:28 UTC 2023 , Edited by admin on Sat Dec 16 05:33:28 UTC 2023

PRIMARY

EPA CompTox

DTXSID10169915

Created by admin on Sat Dec 16 05:33:28 UTC 2023 , Edited by admin on Sat Dec 16 05:33:28 UTC 2023

PRIMARY

PUBCHEM

9887837

Created by admin on Sat Dec 16 05:33:28 UTC 2023 , Edited by admin on Sat Dec 16 05:33:28 UTC 2023

PRIMARY

Related Record Type Details


					PYF7O1FV7F

FLUVASTATIN SODIUM

PARENT -> IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:

Details

SMILES

InChI

DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/19418962Curator's Comment: The description was created based on several sources, including https://www.jstage.jst.go.jp/article/dmpk1986/10/6/10_6_779/_pdf

Originator

Approval Year

Conditions

PubMed

Sample Use Guides

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/19418962
Curator's Comment: The description was created based on several sources, including https://www.jstage.jst.go.jp/article/dmpk1986/10/6/10_6_779/_pdf