FLUOROQUINOLONIC ACID

Details

Stereochemistry	ACHIRAL
Molecular Formula	C13H9ClFNO3
Molecular Weight	281.667
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)C1=CN(C2CC2)C3=C(C=C(F)C(Cl)=C3)C1=O

InChI

InChIKey=ISPVACVJFUIDPD-UHFFFAOYSA-N

InChI=1S/C13H9ClFNO3/c14-9-4-11-7(3-10(9)15)12(17)8(13(18)19)5-16(11)6-1-2-6/h3-6H,1-2H2,(H,18,19)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25705547
Curator's Comment: The description was created based on several sources, including https://www.google.com.na/patents/DE3142854 | https://www.ncbi.nlm.nih.gov/pubmed/16386005

Fluoroquinolonic acid is major impurity present in Fluoroquinolone Antibacterial Agents such as Enrofloxacin or ciprofloxacin of metoclopramide. Fluoroquinolonic acid shows weak antimicrobial activity.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
Synthesis and in vitro antimicrobial study of Schiff base and thiazolidinone of 1-cyclopropyl-6-fluoro-7-[4-(2,3-dichlorophenyl)piperazin-1-yl]-4-quinolone.	2010 Jan-Feb	20210078

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Antimicrobial activity of Fluoroquinolonic acid was evaluated in vitro in two Gram positive bacteria S. aureus MTCC - 96, S. pyogenes MTCC - 443 and two Gram negative bacteria E. coli MTCC - 442, P. aeruginosa MTCC - 441 and fungi C. albicans MTCC - 227, A. niger MTCC - 282 and A. clavatus MTCC - 1323 organisms by broth dilution method. DMSO was used as a diluent which not effected the growth of microbes. MIC Fluoroquinolonic acid for Gram negative and Gram positive bacteria were 100 mkg/ml, for fungi 500-1000 mkg/ml

Name

Type

Language

FLUOROQUINOLONIC ACID

Systematic Name

English

7-CHLORO-1-CYCLOPROPYL-6-FLUORO-3-CARBOXY-1,4-DIHYDRO-4-OXOQUINOLINE

Systematic Name

English

7-CHLORO-1-CYCLOPROPYL-6-FLUOROQUINOLIN-4-ONE-3-CARBOXYLIC ACID

Common Name

English

1-CYCLOPROPYL-6-FLUORO-7-CHLORO-1,4-DIHYDRO-4-OXOQUINOLIN-3-CARBOXYLIC ACID

Systematic Name

English

3-QUINOLINECARBOXYLIC ACID, 7-CHLORO-1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-4-OXO-

Common Name

English

ENROFLOXACIN IMPURITY A

Common Name

English

7-CHLORO-1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID

Systematic Name

English

FLUOROQUINOLONIC ACID [USP IMPURITY]

Common Name

English

1-CYCLOPROPYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID

Systematic Name

English

ENROFLOXACIN FOR VETERINARY USE IMPURITY A [EP IMPURITY]

Common Name

English

CIPROFLOXACIN IMPURITY A [EP IMPURITY]

Common Name

English

FLUOROQUINOLONIC ACID [USP-RS]

Common Name

English

7-CHLORO-1-CYCLOPROPYL-6-FLUORO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID

Systematic Name

English

Code System Code Type Description

PUBCHEM

483180