U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 641 - 650 of 2596 results

Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

ALCLOFENAC MONOETHANOLAMINE is an ethanolamine salt of alclofenac, approved non-steroidal anti-inflammatory drug.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Gabazine (SR-95531) is a selective GABAA receptors antagonist, which does not have any role in medicine, but is used in scientific experiments as the allosteric inhibitor of channel opening for the GABAA receptor.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Methyl 4-acetamido-5-chloro-2-methoxybenzoate is one of metoclopramide impurities.
SKF-83822 is a D1/D5 receptor agonist, which activates D1-like receptors coupled to stimulation of adenyl cyclase (AC), but not phosphoinositide (PI) hydrolysis. SKF-83822 is used as a tool compound to study the role of AC-coupled D1 receptors.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

Methyl-1-testosterone(M1T)(17alpha-hydroxy-17-methyl- 5-androst-1-en-3-one) is a new designer steroid that is most likely produced to circumvent the legal restrictions. It is advertised to be highly anabolic and moderately androgenic and not convertible to estrogens. However, in scientific literature, it was reported to show anabolic properties of 25% and androgenic properties of 50% compared with testosterone propionate after im injection in castrated rats. In February 2006, Health Canada (Federal Department) warned consumers not to use M1T-containing products because of potentially serious health risks such as liver disorders and hardening of the arteries. Since 2006, M1T is explicitly listed on the World Anti-Doping Agency list of prohibited substances, and therefore, its use by athletes is prohibited.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

Ponasterone A is a member of the ecdysteroid family, and an agonist of edysone receptor (EcR). It is an insect steroid hormone that regulates the metamorphosis of Drosophila melanogaster. As it don't have a target in mammalian cells, it is used as a tool compound to activate EcR in artificially engineered cells.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

1-(2-Chloroethyl)pyrrolidine is a haloalkyl substituted pyrrolidine. It is an intermediate in the synthesis of various pharmaceutical compound. For example, 1-(2-Chloroethyl)pyrrolidine is used for the synthesis of cholinesterase inhibitors and nonsteroidal selective estrogen receptor modulator nafoxidine.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

The main use of p-tert-butylphenol (P.T.B.P.) is the production of resins for adhesives used in the car industry. It is a white crystalline solid which melts at 97-98 oC to a clear, colourless liquid, and vaporises at 260 oC. It has being shown that occupational exposure to p-tert-butylphenol (ptBP) leads to vitiligo. Aminopyrine demethylase inhibitor.
(-)-vesamicol is an active enantiomer of vesamicol (AH5183 or [(-)-trans-2-(4-phenylpiperidino)cyclohexanol]). It inhibits the uptake of acetylcholine into cholinergic neuronal storage vesicles. Vesicular acetylcholine transporter (VAChT) is inhibited by (-)-vesamicol, which binds tightly to an allosteric site.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Sunifiram (DM235) is a piperazine derived research chemical which has anti-amnesiac effects in animal studies. Though Sunifiram is a piracetam derivative, it has a different chemical structure from the racetams and is chemically classed as a piperazine alkaloid. It is known to work in two ways, both as an ampakine that stimulates the activity of glutamine receptors and as a cholinergic that increases the production and release of acetylcholine. Like many nootropics, Sunifiram’s precise mechanisms of action are not entirely understood. However, it is believed that its primary action is that of an ampakine, which means that after crossing the blood-brain barrier it binds to AMPA-type glutamate receptors in the brain. This stimulates the production of glutamate, a vital neurotransmitter that plays the pivotal role in neural activation. Sunifiram is also thought to act as a cholinergic, increasing the production and release of the neurotransmitter acetylcholine. Though the exact process by which this occurs has not been identified, an Italian animal study showed that tests using piperazine compounds such as Sunifiram had a cholinergic effect similar to that of piracetam. No serious side effects of Sunifiram have been documented, but it’s important to remember that no human studies or clinical trials have been conducted.