Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C27H44O6 |
| Molecular Weight | 464.6347 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 10 / 10 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)CC[C@@H](O)[C@](C)(O)[C@H]1CC[C@@]2(O)C3=CC(=O)[C@@H]4C[C@@H](O)[C@@H](O)C[C@]4(C)[C@H]3CC[C@]12C
InChI
InChIKey=PJYYBCXMCWDUAZ-JJJZTNILSA-N
InChI=1S/C27H44O6/c1-15(2)6-7-23(31)26(5,32)22-9-11-27(33)17-12-19(28)18-13-20(29)21(30)14-24(18,3)16(17)8-10-25(22,27)4/h12,15-16,18,20-23,29-33H,6-11,13-14H2,1-5H3/t16-,18-,20+,21-,22-,23+,24+,25+,26+,27+/m0/s1
DescriptionCurator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/21958154
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/21958154
Ponasterone A is a member of the ecdysteroid family, and an agonist of edysone receptor (EcR). It is an insect steroid hormone that regulates the metamorphosis of Drosophila melanogaster. As it don't have a target in mammalian cells, it is used as a tool compound to activate EcR in artificially engineered cells.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Ecdysteroid receptor from the American lobster Homarus americanus: EcR/RXR isoform cloning and ligand-binding properties. | 2011-09-01 |
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| Regulation and dysregulation of vitellogenin mRNA accumulation in daphnids (Daphnia magna). | 2011-01-25 |
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| Epigenetic modulation of endogenous tumor suppressor expression in lung cancer xenografts suppresses tumorigenicity. | 2007-01-01 |
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| Human UDP-glucuronosyltransferase (UGT)1A3 enzyme conjugates chenodeoxycholic acid in the liver. | 2006-11 |
|
| Prostaglandin E2 promotes cell survival of glomerular epithelial cells via the EP4 receptor. | 2006-06 |
Patents
Sample Use Guides
Binding to purified ecdysone receptor from Nezara viridula was studied using filtration assay. [3H]Ponasterone A (PonA) was used as a radioligand. Purified recombinant LBR heterodimer (13 pmol of protein per reaction at a concentration of 430 nM) was equilibrated at 21C in the presence of both 1.3 nM of [3H]PonA and dilution series of competitor compound. The incubation time was 5 hours. Glass-filter capture of receptor–ligand complexes from each reaction was performed using a 96-well filter plate.
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m8980
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13408-56-5
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SUBSTANCE RECORD
