Ectoine is a natural compound found in several species of bacteria, including heterotrophic, halophilic bacteria and non-halophilic bacteria such as Streptomyces species and E.coli. It serves as an osmoprotectant, protecting microorganisms from high concentrations of salts. Ectoine is used as a protective agent for E.Coli during drying and storage. In the cosmetic and drug industry, ectoine is used as an active ingredient in skin care and sun protection products, working by stabilization proteins and other cellular structures. Ectoine has a number of applications in medicine: it alleviates inflammation reactions, protects cells from damage during cryopreservation, protects against neurodegenerative diseases and from against ischemia and reperfusion injury. Ectoine-containing formulations are investigated in the clinical trials for the treatment of allergic rhinitis and conjunctivitis, atopic dermatitis, asthma, and other conditions.

Sodium Ursolate (Ursolic acid sodium salt) is a natural active ingredient derived from many plants. This pentacyclic triterpenoid acid is manufactured by extraction of Salvia officinalis leaves, also known as common sage, Loquat leaves and Olea europea. Sodium Ursolate provides a targeted approach to anti-aging skin repair and sun protection through reactivation, protection and optimization of the skins own cellular mechanisms. Furthermore, it protects and refolds proteins damaged by UV and free radical exposure and stimulates new collagen synthesis to counter the effects of thinning and sagging skin caused by photodamage, inhibits elastase and stabilizes liposomal membranes. It is of most interest to use in Anti-Aging and Anti-Photo-Aging cosmetics products.

Protocatechualdehyde (protocatechuic aldehyde) is a naturally occurring phenolic aldehyde that is found in barley, green cavendish bananas, grapevine leaves and root of the herb S. miltiorrhiza. There is evidence for anticancer activity of protocatechualdehyde in human colorectal cancer and breast cancer. Protocatechualdehyde leads to the inhibition of cell growth and the promotion of apoptosis through HDAC2-mediated cyclin D1 suppression in human colorectal cancer cells. In human breast cancer cells, protocatechualdehyde downregulates β-catenin and cyclin D1 through activating proteosomal degradation. The risk or severity of bleeding can be increased as a result of interaction of protocatechualdehyde with many drugs an dietary supplements (89 compounds reported).

Zinc Ascorbate can be used as a dietary supplement and as a nutrient. Zinc is an important antioxidant nutrient. It is necessary for protein synthesis, wound healing, for blood stability, normal tissue function, and aids in the digestion and metabolism of phosphorus. It also governs the contractility of muscles and maintains the body’s alkaline balance. Zinc ascorbate has superoxide dismutase-like activity and in vitro antimicrobial activity against Staphylococcus aureus and Escherichia coli. Zinc ascorbate may be effective for acne treatment. Zinc ascorbate inhibits the growth of P. acnes (MIC, 640 ug/mL).