ZINC ASCORBATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	2C6H7O6.Zn
Molecular Weight	415.641
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Zn++].[H][C@@]1(OC(=O)C(O)=C1[O-])[C@@H](O)CO.[H][C@@]2(OC(=O)C(O)=C2[O-])[C@@H](O)CO

InChI

InChIKey=WWRJFSIRMWUMAE-ZZMNMWMASA-L

InChI=1S/2C6H8O6.Zn/c2*7-1-2(8)5-3(9)4(10)6(11)12-5;/h2*2,5,7-10H,1H2;/q;;+2/p-2/t2*2-,5+;/m00./s1

HIDE SMILES / InChI

Molecular Formula	C6H7O6
Molecular Weight	175.1162
Charge	-1
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	Zn
Molecular Weight	65.409
Charge	2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/23055762 | https://www.jostchemical.com/products/zinc/productcode2931/

Zinc Ascorbate can be used as a dietary supplement and as a nutrient. Zinc is an important antioxidant nutrient. It is necessary for protein synthesis, wound healing, for blood stability, normal tissue function, and aids in the digestion and metabolism of phosphorus. It also governs the contractility of muscles and maintains the body’s alkaline balance. Zinc ascorbate has superoxide dismutase-like activity and in vitro antimicrobial activity against Staphylococcus aureus and Escherichia coli. Zinc ascorbate may be effective for acne treatment. Zinc ascorbate inhibits the growth of P. acnes (MIC, 640 ug/mL).

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Staphylococcus aureus 67 Target ID: CHEMBL352 Sources: https://www.ncbi.nlm.nih.gov/pubmed/23055762	Inhibitor 8297
Escherichia coli 82 Target ID: CHEMBL354 Sources: https://www.ncbi.nlm.nih.gov/pubmed/23055762	Inhibitor 8297
Propionibacterium acnes 6 Target ID: CHEMBL612639 Sources: https://www.ncbi.nlm.nih.gov/pubmed/23055762	Inhibitor 8297
reactive oxygen species metabolic process 68 Target ID: GO:0072593 Sources: https://www.ncbi.nlm.nih.gov/pubmed/23055762 \| https://www.ncbi.nlm.nih.gov/pubmed/22087070	Modulator 828

Conditions

Condition	Modality	Highest Phase	Product
Acne 98 Sources: https://www.ncbi.nlm.nih.gov/pubmed/23055762 https://www.ncbi.nlm.nih.gov/pubmed/22087070	Curative	Basic research	Unknown Approved Use Unknown
Gingivitis 44 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11968899	Primary	Preclinical	Unknown Approved Use Unknown
Dental plaque 13 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11968899 https://www.ncbi.nlm.nih.gov/pubmed/11460284	Primary	Preclinical	Unknown Approved Use Unknown
Vitamin C and Zn deficiency 1 Sources: http://www.fda.gov.ph/consumers-corner/registered-drugs-2/214008-DR-XY39935 http://www.fda.gov.ph/registered-drugs/191658-dr-xy41246	Preventing	Approved 8429	Cixtor-Z Approved Use Treatment and prevention of vit C & Zn deficiency.

PubMed

Title	Date	PubMed
Zinc ascorbate has superoxide dismutase-like activity and in vitro antimicrobial activity against Staphylococcus aureus and Escherichia coli.	2012	23055762
Zinc-chelated Vitamin C Stimulates Adipogenesis of 3T3-L1 Cells.	2013 Aug	25049900

Patents

Sample Use Guides

In Vivo Use Guide

Syr Childn & adolescent 2.5-5 mL (½-1 tsp) once daily. Drops Infant & young childn 0.5-1 mL once daily. Per 5 mL syr Ascorbic acid (as Na ascorbate) 97.5 mg, Zn (as Zn ascorbate) 9 mg. Per mL drops Ascorbic acid (as Na ascorbate) 45 mg, Zn (as Zn ascorbate) 4.5 mg

Route of Administration: Oral

In Vitro Use Guide

MIC of zinc ascorbate was 640 ug/mL against S. aureus and 1280 ug/mL against E. coli.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:41:55 UTC 2023` Edited by `admin` on `Fri Dec 15 18:41:55 UTC 2023`
Record UNII	9TI35313XW
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ZINC ASCORBATE

Official Name

English

L-ASCORBIC ACID, ZINC SALT (2:1)

Common Name

English

ZINC ASCORBATE [INCI]

Common Name

English

Zinc Ascorbate [WHO-DD]

Common Name

English

L-ASCORBIC ACID, ZINC SALT

Common Name

English

(-)-ASCORBIC ACID, ZINC SALT

Common Name

English

Classification Tree Code System Code

DSLD

2524 (Number of products:13)