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Status:
First approved in 1974
Class (Stereo):
CHEMICAL (ABSOLUTE)
Cephacetrile, a parenteral cephalosporin, is a broad-spectrum first generation cephalosporin antibiotic effective in Gram-positive and Gram-negative bacterial infections. It works by inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cephacetrile was used in the treatment of female pelvic inflammatory disease, meningitis and number of other systemic, respiratory and urinary infections.
Status:
US Previously Marketed
Source:
PEPTAVLON by WYETH AYERST
(1974)
Source URL:
First approved in 1974
Source:
PEPTAVLON by WYETH AYERST
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Pentagastrin (trade name Peptavlon) is a cholecystokinin type B (CCK(B)) receptor agonist, which was indicated as a diagnostic aid for evaluation of gastric acid secretory function. It was effective in testing for an acidity (achlorhydria) in patients with suspected pernicious anemia, atrophic gastritis, or gastric carcinoma. It was effective in determining the reduction in acid output after operations for peptic ulcer, such as vagotomy or gastric resection. Pentagastrin was also indicated as a diagnostic aid in testing for gastric hypersecretion in patients with suspected duodenal ulcer or postoperative stomal ulcer, and for the diagnosis of Zollinger-Ellison tumor. Peptavlon was discontinued, Federal Register determined that product was not discontinued or withdrawn for safety or efficacy reasons. In addition was shown, that Pentagastrin may release adrenocorticotropin (ACTH) and cortisol through direct pharmacological action, perhaps enhanced on first exposure by psychologically mediated novelty effects. Novelty, per se, is not likely the primary mediator of the hypothalamic-pituitary-adrenal (HPA) response. This model may be useful for further study of cognitive-emotional modulators of HPA axis activity.
Status:
US Previously Marketed
Source:
DICOPAC KIT by GE HEALTHCARE
(1974)
Source URL:
First approved in 1974
Source:
DICOPAC KIT by GE HEALTHCARE
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Cyanocobalamin Co 57 is a manufactured form of radiolabeled vitamin B indicated as an adjunct in diagnosing intestinal cyanocobalamin malabsorption syndromes due to lack of intrinsic factor (IF) or other defects in intestinal absorption (e.g., blind loop syndrome and diverticulitis, celiac disease, Crohn's disease, lesions in the small intestine, severe pancreatitis, tropical sprue).
Status:
US Previously Marketed
Source:
ISMOTIC by ALCON
(1974)
Source URL:
First approved in 1974
Source:
ISMOTIC by ALCON
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Isosorbide is an effective hyperosmotic agent which can be administered orally without gastrointestinal irritation. It is absorbed quantitatively and more than 95% of the administered dose is excreted unchanged in the urine. Oral administration of a 50% solution to rabbits or man results in prompt increases in osmolarity of the serum and profound decreases in intraocular pressure. The drug proves useful in acute primary and secondary glaucomas, and as preoperative medication for various surgical procedures including cataract extraction, retinal detachment, corneal transplant, and glaucoma operations.
Status:
US Previously Marketed
Source:
CHLORMERODRIN HG 197 by BRACCO
(1974)
Source URL:
First approved in 1974
Source:
CHLORMERODRIN HG 197 by BRACCO
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Conditions:
CHLORMERODRIN HG-197 is a radiolabelled form of chlormerodrin, an organomercury compound that was previously used as a diuretic. Its radiolabelled form was used as diagnostics in brain scans.
Status:
Possibly Marketed Outside US
Source:
21 CFR 333D
(2006)
Source URL:
First approved in 1974
Source:
21 CFR 358A
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Possibly Marketed Outside US
Source:
HERBALIFE SKIN 7 DAY RESULTS KIT
Source URL:
First approved in 1974
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Status:
Possibly Marketed Outside US
Source:
Topex 60 Second Fluoride FoamStrawberry by Dentsply LLC. Professional Division Trading as Sultan Healthcare
(1997)
Source URL:
First approved in 1974
Source:
Topex by Dentsply LLC. Professional Division Trading as Sultan Healthcare
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Apaflurane (HFC 227) is gaseous halocarbon commonly used as a gaseous fire suppression agent, it is a CFC-free propellant. Apaflurane is used to replace chlorofluorocarbons (CFCs) in refrigerant and aerosol applications, including medical use in metered-dose inhalers.
Status:
Possibly Marketed Outside US
Source:
M
(1974)
Source URL:
First approved in 1974
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Possibly Marketed Outside US
Source:
M
(1974)
Source URL:
First approved in 1974
Class (Stereo):
CHEMICAL (ACHIRAL)
Butane is gaseous alkane with four carbon atoms. Normal butane can be used for gasoline blending, as a fuel gas, fragrance extraction solvent, either alone or in a mixture with propane, and as a feedstock for the manufacture of ethylene and butadiene, a key ingredient of synthetic rubber. Butane is known to be a suffocating gas with a narcotic action. Inhalation of butane can cause euphoria, drowsiness, unconsciousness, asphyxia, cardiac arrhythmia, fluctuations in blood pressure and temporary memory loss, when abused directly from a highly pressurized container, and can result in death from asphyxiation and ventricular fibrillation. Abuse is frequent because butane is easily available and its sale is not restricted. Cases of sudden death in teenagers have been increasing since the 1980s , and over the past few years, there have been an increasing number of publications on the subject.