APAFLURANE

First approved in 1974

Details

Stereochemistry	ACHIRAL
Molecular Formula	C3HF7
Molecular Weight	170.0289
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC(C(F)(F)F)C(F)(F)F

InChI

InChIKey=YFMFNYKEUDLDTL-UHFFFAOYSA-N

InChI=1S/C3HF7/c4-1(2(5,6)7)3(8,9)10/h1H

HIDE SMILES / InChI

Molecular Formula	C3HF7
Molecular Weight	170.0289
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11029265 | https://www.mydr.com.au/medicines/cmis/flutiform | https://www.ncbi.nlm.nih.gov/pubmed/22519407

Apaflurane (HFC 227) is gaseous halocarbon commonly used as a gaseous fire suppression agent, it is a CFC-free propellant. Apaflurane is used to replace chlorofluorocarbons (CFCs) in refrigerant and aerosol applications, including medical use in metered-dose inhalers.

Approval Year

PubMed

Title	Date	PubMed
Novel nanoparticles for pulmonary drug administration.	2001	11697032
Determination of 1,1,1,2,3,3,3-heptafluoropropane (HFP) in blood by headspace gas chromatography-mass spectrometry.	2005 Sep	16168182
Structural identification of isomers present in technical perfluorooctane sulfonate by tandem mass spectrometry.	2006	16470576
Synthesis of perfluoroalkyl-substituted azines via nucleophilic substitution of hydrogen with perfluoroisopropyl carbanions.	2007 Feb 16	17243722
Characterization of fine particle and gaseous emissions during school bus idling.	2007 Jul 15	17711211
Biocompatible and biodegradable copolymer stabilizers for hydrofluoroalkane dispersions: a colloidal probe microscopy investigation.	2007 Nov 20	17958454
Solvent-solute interactions in hydrofluoroalkane propellants.	2008 Jul 10	18598010
Effects on small airway obstruction of long-term treatments with beclomethasone/formoterol hydrofluoroalkane (metered-dose inhaler) versus fluticasone/salmeterol (dry-powder inhaler) in asthma: a preliminary study.	2011 Nov-Dec	22221427

Patents

Sample Use Guides

In Vivo Use Guide

The safety and pharmacokinetics of HFC 134a and HFC 227 were assessed in two separate double-blind studies. Each HFC (hydrofluorocarbon) was administered via whole-body exposure as a vapor to eight (four male and four female) healthy volunteers. Volunteers were exposed, once weekly for 1 h, first to air and then to ascending concentrations of HFC (1000, 2000, 4000, and 8000 parts per million (ppm)). Exposure of healthy volunteers to exposure levels up to 8000 ppm HFC 134a, 8000 ppm HFC 227, and 4000 ppm CFC 12 did not result in any adverse effects on pulse, blood pressure, electrocardiogram, or lung function.

Route of Administration: Respiratory

Substance Class	Chemical Created by `admin` on `Sat Dec 16 05:09:10 UTC 2023` Edited by `admin` on `Sat Dec 16 05:09:10 UTC 2023`
Record UNII	R40P36GDK6
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

APAFLURANE

Official Name

English

HFC-227

Code

English

HYDROFLUOROCARBON 227EA [INCI]

Common Name

English

R-227

Code

English

1,1,1,2,3,3,3-HEPTAFLUOROPROPANE

Systematic Name

English

SOLKANE 227

Brand Name

English

HFC-227EA

Code

English

APAFLURANE [MART.]

Common Name

English

2-HYDROHEPTAFLUOROPROPANE

Common Name

English

apaflurane [INN]

Common Name

English

HYDROFLUOROCARBON 227EA

Official Name

English

APAFLURANE [II]

Common Name

English

PROPANE, 1,1,1,2,3,3,3-HEPTAFLUORO-

Systematic Name

English

HFA-227

Code

English

HFA-227EA

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C1937