U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C3HF7
Molecular Weight 170.0289
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of APAFLURANE

SMILES

FC(C(F)(F)F)C(F)(F)F

InChI

InChIKey=YFMFNYKEUDLDTL-UHFFFAOYSA-N
InChI=1S/C3HF7/c4-1(2(5,6)7)3(8,9)10/h1H

HIDE SMILES / InChI

Molecular Formula C3HF7
Molecular Weight 170.0289
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Apaflurane (HFC 227) is gaseous halocarbon commonly used as a gaseous fire suppression agent, it is a CFC-free propellant. Apaflurane is used to replace chlorofluorocarbons (CFCs) in refrigerant and aerosol applications, including medical use in metered-dose inhalers.

Approval Year

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
The safety and pharmacokinetics of HFC 134a and HFC 227 were assessed in two separate double-blind studies. Each HFC (hydrofluorocarbon) was administered via whole-body exposure as a vapor to eight (four male and four female) healthy volunteers. Volunteers were exposed, once weekly for 1 h, first to air and then to ascending concentrations of HFC (1000, 2000, 4000, and 8000 parts per million (ppm)). Exposure of healthy volunteers to exposure levels up to 8000 ppm HFC 134a, 8000 ppm HFC 227, and 4000 ppm CFC 12 did not result in any adverse effects on pulse, blood pressure, electrocardiogram, or lung function.
Route of Administration: Respiratory
Substance Class Chemical
Record UNII
R40P36GDK6
Record Status Validated (UNII)
Record Version