IDRX-42

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NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C29H32N8O
Molecular Weight	508.6174
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of IDRX-42

Structure Search

SMILES

CN1C=C(C=N1)C2=CC=C(CNC3=CC(=NC=N3)C4=CN=C5C=C(OCCCN6CCCC6)C=CN45)C=C2

InChI

InChIKey=LVMAULGVWBINFP-UHFFFAOYSA-N

InChI=1S/C29H32N8O/c1-35-20-24(18-34-35)23-7-5-22(6-8-23)17-30-28-16-26(32-21-33-28)27-19-31-29-15-25(9-13-37(27)29)38-14-4-12-36-10-2-3-11-36/h5-9,13,15-16,18-21H,2-4,10-12,14,17H2,1H3,(H,30,32,33)

HIDE SMILES / InChI

Molecular Formula	C29H32N8O
Molecular Weight	508.6174
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Wed Apr 02 10:15:28 GMT 2025` Edited by `admin` on `Wed Apr 02 10:15:28 GMT 2025`
Record UNII	Y6UHU32G5Z
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

4-Pyrimidinamine, N-[[4-(1-methyl-1H-pyrazol-4-yl)phenyl]methyl]-6-[7-[3-(1-pyrrolidinyl)propoxy]imidazo[1,2-a]pyridin-3-yl]-

Preferred Name

English

IDRX-42

Code

English

M-4205

Code

English

[4-(Methyl-1H-pyrazol-4-yl)-benzyl] -(6-[7-(3-pyrrolidin-1-yl-propoxy)-imidazo[1,2-a] pyridin-3-yl]-pyrimidin-4-yl]-amine

Systematic Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

892122

Created by admin on Wed Apr 02 10:15:28 GMT 2025 , Edited by admin on Wed Apr 02 10:15:28 GMT 2025

Code System Code Type Description

SMS_ID

300000043439

Created by admin on Wed Apr 02 10:15:28 GMT 2025 , Edited by admin on Wed Apr 02 10:15:28 GMT 2025

PRIMARY

PUBCHEM

155587867

Created by admin on Wed Apr 02 10:15:28 GMT 2025 , Edited by admin on Wed Apr 02 10:15:28 GMT 2025

PRIMARY

FDA UNII

Y6UHU32G5Z

Created by admin on Wed Apr 02 10:15:28 GMT 2025 , Edited by admin on Wed Apr 02 10:15:28 GMT 2025

PRIMARY

CAS

2590556-80-0

Created by admin on Wed Apr 02 10:15:28 GMT 2025 , Edited by admin on Wed Apr 02 10:15:28 GMT 2025

PRIMARY

NCI_THESAURUS

C190128

Created by admin on Wed Apr 02 10:15:28 GMT 2025 , Edited by admin on Wed Apr 02 10:15:28 GMT 2025

PRIMARY

Related Record Type Details


					AE9XK4U45L

IDRX-42 HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Amount:


					O2MTR8W9R0

TYROSINE-PROTEIN KINASE LCK

TARGET -> INHIBITOR

Qualification:

IC50

Amount:


					OVI08ABI5H

MAST/STEM CELL GROWTH FACTOR RECEPTOR KIT

TARGET -> INHIBITOR

Qualification:

IC50

Amount:


					9B09G8YMGH

PLATELET-DERIVED GROWTH FACTOR RECEPTOR BETA

TARGET -> INHIBITOR

Qualification:

IC50

Amount:


					4796L35A70

RECEPTOR-TYPE TYROSINE-PROTEIN KINASE FLT3

TARGET -> INHIBITOR

Qualification:

IC50

Amount:


					EXBA2DRFUB

PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA

TARGET -> INHIBITOR

Qualification:

IC50

Amount:


					2VXO9I489U

MACROPHAGE COLONY-STIMULATING FACTOR 1 RECEPTOR

TARGET -> INHIBITOR

Qualification:

IC50

Amount:

Related Record Type Details


					Y6UHU32G5Z

IDRX-42

ACTIVE MOIETY

Comments:

M4205 is planned for clinical development for the treatment of patients with unresectable metastatic or recurrent gastrointestinal stromal tumors (GIST). GIST are the most common human sarcomas and driven by activating mutations in cKIT (~80%) and the related PDGFRA (~5% to 10%) receptor tyrosine kinases

Amount: