U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Tue Apr 01 19:18:25 GMT 2025
Edited
by admin
on Tue Apr 01 19:18:25 GMT 2025
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
OVI08ABI5H
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MAST/STEM CELL GROWTH FACTOR RECEPTOR KIT
Common Name English
CD117
Preferred Name English
PBT
Common Name English
SCFR
Common Name English
P145 C-KIT
Common Name English
PROTO-ONCOGENE C-KIT
Common Name English
TYROSINE-PROTEIN KINASE KIT
Common Name English
KIT
Common Name English
V-KIT HARDY-ZUCKERMAN 4 FELINE SARCOMA VIRAL ONCOGENE HOMOLOG
Common Name English
PIEBALD TRAIT PROTEIN
Common Name English
Code System Code Type Description
WIKIPEDIA
CD117
Created by admin on Tue Apr 01 19:18:25 GMT 2025 , Edited by admin on Tue Apr 01 19:18:25 GMT 2025
PRIMARY
UNIPROT
P10721
Created by admin on Tue Apr 01 19:18:25 GMT 2025 , Edited by admin on Tue Apr 01 19:18:25 GMT 2025
PRIMARY
EC (ENZYME CLASS)
EC 2.7.10.1
Created by admin on Tue Apr 01 19:18:25 GMT 2025 , Edited by admin on Tue Apr 01 19:18:25 GMT 2025
PRIMARY
FDA UNII
OVI08ABI5H
Created by admin on Tue Apr 01 19:18:25 GMT 2025 , Edited by admin on Tue Apr 01 19:18:25 GMT 2025
PRIMARY
SMS_ID
300000041070
Created by admin on Tue Apr 01 19:18:25 GMT 2025 , Edited by admin on Tue Apr 01 19:18:25 GMT 2025
PRIMARY
From To
1_33 1_72
1_111 1_161
1_126 1_158
1_208 1_265
1_403 1_466
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_105
N 1_120
N 1_258
N 1_268
N 1_275
N 1_295
N 1_327
N 1_342
N 1_438
N 1_461
Related Record Type Details
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INHIBITOR
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Structure of TELATINIB
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Structure of SUNITINIB
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Structure of DOVITINIB
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INHIBITOR
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INHIBITOR -> TARGET
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Structure of QUIZARTINIB
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Kd
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Structure of PEXIDARTINIB
INHIBITOR -> TARGET
IC50
Structure of CRENOLANIB
INHIBITOR -> TARGET
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Structure of CEDIRANIB
INHIBITOR -> TARGET
IN-VITRO
IC50
Structure of SUNITINIB
INHIBITOR -> TARGET
INHIBITOR
Briquilimab
INHIBITOR -> TARGET
Structure of FAMITINIB
INHIBITOR -> TARGET
INHIBITOR
Structure of Nilotinib
INHIBITOR -> TARGET
INHIBITOR
Structure of DASATINIB
INHIBITOR -> TARGET
INHIBITOR
Structure of CRENOLANIB
INHIBITOR -> TARGET
Kd
BINDING
Structure of IMATINIB
INHIBITOR -> TARGET
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BINDING
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INHIBITOR
Mast/stem cell growth factor receptor Kit V654A
PARENT->MUTANT
Structure of SU-11652
INHIBITOR -> TARGET
IN-VITRO
IC50
CDX-0158
INHIBITOR -> TARGET
Kd
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INHIBITOR -> TARGET
Kd; Target: KIT
INHIBITOR
Structure of QUIZARTINIB
INHIBITOR -> TARGET
INHIBITOR
Structure of FAMITINIB
INHIBITOR -> TARGET
IN-VITRO
IC50
Structure of FLUORO-DASATINIB F-18
RADIOLIGAND->TARGET
Structure of DASATINIB ANHYDROUS
INHIBITOR -> TARGET
IC50
Structure of MASITINIB
INHIBITOR -> TARGET
INHIBITOR
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INHIBITOR -> TARGET
INHIBITOR
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INHIBITOR -> TARGET
Kd
BINDING
Structure of DASATINIB
INHIBITOR -> TARGET
Kd (pKd=9.1); Target: KIT
BINDING
Structure of RIPRETINIB
INHIBITOR -> TARGET
Structure of DOVITINIB
INHIBITOR -> TARGET
IN-VITRO
IC50
Structure of ILORASERTIB
INHIBITOR -> TARGET
Structure of SERALUTINIB
INHIBITOR -> TARGET
Structure of JNJ-28312141 FREE BASE
INHIBITOR -> TARGET
as a monohydrochloride salt
IN-VITRO
IC50

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_796] [1_866] [1_934] DEXFOSFOSERINE VI4F0K069V
AMINO ACID SUBSTITUTION [1_522] [1_528] [1_543] [1_545] [1_678] [1_696] [1_705] [1_798] [1_875] [1_911] TYROSINE O-PHOSPHATE 2R86C98KDX
AMINO ACID SUBSTITUTION [1_716] [1_721] DEXFOSFOSERINE VI4F0K069V
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT CHEMICAL
NIH
NCATS
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