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Details

Stereochemistry ACHIRAL
Molecular Formula C23H27FN4O2
Molecular Weight 410.4854
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of FAMITINIB

SMILES

CCN(CC)CCN1CCc2c(c(C)c(/C(/[H])=C\3/c4cc(ccc4N=C3O)F)[nH]2)C1=O

InChI

InChIKey=GKEYKDOLBLYGRB-LGMDPLHJSA-N
InChI=1S/C23H27FN4O2/c1-4-27(5-2)10-11-28-9-8-19-21(23(28)30)14(3)20(25-19)13-17-16-12-15(24)6-7-18(16)26-22(17)29/h6-7,12-13,25H,4-5,8-11H2,1-3H3,(H,26,29)/b17-13-

HIDE SMILES / InChI

Molecular Formula C23H27FN4O2
Molecular Weight 410.4854
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Famitinib, an orally active, small molecule, is a tyrosine kinase inhibitor against multiple targets, including vascular endothelial growth factor receptor 2/3, platelet-derived growth factor receptor, and stem cell factor receptor (c-kit). Jiangsu Hengrui Medicine Co is developing famitinib against a wide variety of advanced-stage solid cancers. Famitinib is participating in phase III clinical trials to evaluate its safety and efficacy in patients with advanced colorectal adenocarcinoma. The other phase III clinical trial for patients with non-squamous non-small cell lung cancer was terminated because of the difficulty in recruitment. In addition, the drug is involved in phase II clinical trials for the treatment of cervical cancer, endometrial cancer, fallopian tube cancer, gastrointestinal stromal tumors, nasopharyngeal cancer, and neuroendocrine tumors.

Approval Year

PubMed

PubMed

TitleDatePubMed
Novel potent orally active multitargeted receptor tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of 2-indolinone derivatives.
2010 Nov 25
Patents

Sample Use Guides

Phase III study. Famitinib 25 mg p.o. qd
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Sat Jun 26 12:42:13 UTC 2021
Edited
by admin
on Sat Jun 26 12:42:13 UTC 2021
Record UNII
768FW21J3L
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FAMITINIB
Common Name English
(Z)-5-(2-(DIETHYLAMINO)ETHYL)-2-((5-FLUORO-2-OXOINDOLIN-3-YLIDENE)METHYL)-3-METHYL-6,7-DIHYDRO-1H-PYRROLO(3,2-C)PYRIDIN-4(5H)-ONE
Systematic Name English
4H-PYRROLO(3,2-C)PYRIDIN-4-ONE, 5-(2-(DIETHYLAMINO)ETHYL)-2-((Z)-(5-FLUORO-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE)METHYL)-1,5,6,7-TETRAHYDRO-3-METHYL-
Systematic Name English
FAMITINIB [WHO-DD]
Common Name English
4H-PYRROLO(3,2-C)PYRIDIN-4-ONE, 5-(2-(DIETHYLAMINO)ETHYL)-2-((5-FLUORO-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE)METHYL)-1,5,6,7-TETRAHYDRO-3-METHYL-
Systematic Name English
SHR1020
Code English
SHR-1020
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C129825
Created by admin on Sat Jun 26 12:42:14 UTC 2021 , Edited by admin on Sat Jun 26 12:42:14 UTC 2021
NCI_THESAURUS C1967
Created by admin on Sat Jun 26 12:42:14 UTC 2021 , Edited by admin on Sat Jun 26 12:42:14 UTC 2021
Code System Code Type Description
NCI_THESAURUS
C97512
Created by admin on Sat Jun 26 12:42:14 UTC 2021 , Edited by admin on Sat Jun 26 12:42:14 UTC 2021
PRIMARY
CAS
1044040-56-3
Created by admin on Sat Jun 26 12:42:14 UTC 2021 , Edited by admin on Sat Jun 26 12:42:14 UTC 2021
PRIMARY
ChEMBL
CHEMBL3545026
Created by admin on Sat Jun 26 12:42:14 UTC 2021 , Edited by admin on Sat Jun 26 12:42:14 UTC 2021
PRIMARY
EVMPD
SUB183614
Created by admin on Sat Jun 26 12:42:14 UTC 2021 , Edited by admin on Sat Jun 26 12:42:14 UTC 2021
PRIMARY
PUBCHEM
16662431
Created by admin on Sat Jun 26 12:42:14 UTC 2021 , Edited by admin on Sat Jun 26 12:42:14 UTC 2021
PRIMARY
CAS
945380-27-8
Created by admin on Sat Jun 26 12:42:14 UTC 2021 , Edited by admin on Sat Jun 26 12:42:14 UTC 2021
NON-SPECIFIC STEREOCHEMISTRY
FDA UNII
768FW21J3L
Created by admin on Sat Jun 26 12:42:14 UTC 2021 , Edited by admin on Sat Jun 26 12:42:14 UTC 2021
PRIMARY
DRUG BANK
DB11741
Created by admin on Sat Jun 26 12:42:14 UTC 2021 , Edited by admin on Sat Jun 26 12:42:14 UTC 2021
PRIMARY
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SALT/SOLVATE -> PARENT
TARGET -> INHIBITOR
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IC50
TARGET -> INHIBITOR
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ACTIVE MOIETY