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Details

Stereochemistry ACHIRAL
Molecular Formula C22H27ClN4O2
Molecular Weight 414.9292
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of SU-11652

SMILES

CCN(CC)CCN=C(c1c(C)c(/C(/[H])=C\2/c3cc(ccc3N=C2O)Cl)[nH]c1C)O

InChI

InChIKey=XPLJEFSRINKZLC-ATVHPVEESA-N
InChI=1S/C22H27ClN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-

HIDE SMILES / InChI

Molecular Formula C22H27ClN4O2
Molecular Weight 414.9292
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P17405
Gene ID: 6609.0
Gene Symbol: SMPD1
Target Organism: Homo sapiens (Human)
Target ID: P36888
Gene ID: 2322.0
Gene Symbol: FLT3
Target Organism: Homo sapiens (Human)
1.5 nM [IC50]
Target ID: P11362|||Q14307|||Q9UDF2
Gene ID: 2260.0
Gene Symbol: FGFR1
Target Organism: Homo sapiens (Human)
0.17 µM [IC50]
Target ID: P09619
Gene ID: 5159.0
Gene Symbol: PDGFRB
Target Organism: Homo sapiens (Human)
0.003 µM [IC50]
Target ID: P35968
Gene ID: 3791.0
Gene Symbol: KDR
Target Organism: Homo sapiens (Human)
0.027 µM [IC50]
PubMed

PubMed

TitleDatePubMed
SU11652 Inhibits tyrosine kinase activity of FLT3 and growth of MV-4-11 cells.
2012 Dec 6
Sunitinib and SU11652 inhibit acid sphingomyelinase, destabilize lysosomes, and inhibit multidrug resistance.
2013 Oct
Pyrrole-indolinone SU11652 targets the nucleoside diphosphate kinase from Leishmania parasites.
2017 Jul 1
Substance Class Chemical
Created
by admin
on Sat Jun 26 00:01:28 UTC 2021
Edited
by admin
on Sat Jun 26 00:01:28 UTC 2021
Record UNII
1C7AZL970U
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SU-11652
Common Name English
5-((Z)-(5-CHLORO-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE)METHYL)-N-(2-(DIETHYLAMINO)ETHYL)-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE
Systematic Name English
SU11652
Code English
1H-PYRROLE-3-CARBOXAMIDE, 5-((Z)-(5-CHLORO-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE)METHYL)-N-(2-(DIETHYLAMINO)ETHYL)-2,4-DIMETHYL-
Systematic Name English
Code System Code Type Description
DRUG BANK
DB08009
Created by admin on Sat Jun 26 00:01:28 UTC 2021 , Edited by admin on Sat Jun 26 00:01:28 UTC 2021
PRIMARY
CAS
326914-10-7
Created by admin on Sat Jun 26 00:01:28 UTC 2021 , Edited by admin on Sat Jun 26 00:01:28 UTC 2021
PRIMARY
PUBCHEM
5329103
Created by admin on Sat Jun 26 00:01:28 UTC 2021 , Edited by admin on Sat Jun 26 00:01:28 UTC 2021
PRIMARY
FDA UNII
1C7AZL970U
Created by admin on Sat Jun 26 00:01:28 UTC 2021 , Edited by admin on Sat Jun 26 00:01:28 UTC 2021
PRIMARY