PROROXAN

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C21H23NO3
Molecular Weight	337.4122
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O=C(CCN1CCC(C1)C2=CC=CC=C2)C3=CC4=C(OCCO4)C=C3

InChI

InChIKey=GZIISXIDAZYOLI-UHFFFAOYSA-N

InChI=1S/C21H23NO3/c23-19(17-6-7-20-21(14-17)25-13-12-24-20)9-11-22-10-8-18(15-22)16-4-2-1-3-5-16/h1-7,14,18H,8-13,15H2

HIDE SMILES / InChI

Molecular Formula	C21H23NO3
Molecular Weight	337.4122
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: http://paper.rsmu.ru/pirogovka_2015/articles/article.php?thesis_number=90 | https://www.ncbi.nlm.nih.gov/pubmed/26087584 | http://noillen.bitballoon.com/medicine2/pirroksan-instructio1832

Proroxan is a non-selective а-adrenoblocker. Proroxan was found to prevent the development of hypertensive crises and improve cerebral bioelectrical parameters in most of hypertensive patients. Proroxan has been used as an antihypertensive and in the treatment of Ménière’s disease, motion sickness, and allergic dermatitis.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Adrenergic receptor alpha-1 169 Target ID: CHEMBL2094251 Sources: http://paper.rsmu.ru/pirogovka_2015/articles/article.php?thesis_number=90 \| https://www.ncbi.nlm.nih.gov/pubmed/26087584 \| http://dspace.vnmu.edu.ua/bitstream/handle/123456789/1660/General_Pharmacology%20and%20drugs%20affecting%20mediatory%20processes.pdf?sequence=1 \| http://medsideen.bitballoon.com/for-the-nervous-syst102/pirroksan2432.html	Antagonist 2778
Adrenergic receptor alpha-2 113 Target ID: CHEMBL2095158 Sources: http://paper.rsmu.ru/pirogovka_2015/articles/article.php?thesis_number=90 \| https://www.ncbi.nlm.nih.gov/pubmed/26087584 \| http://dspace.vnmu.edu.ua/bitstream/handle/123456789/1660/General_Pharmacology%20and%20drugs%20affecting%20mediatory%20processes.pdf?sequence=1 \| http://medsideen.bitballoon.com/for-the-nervous-syst102/pirroksan2432.html	Antagonist 2778

Conditions

Condition	Modality	Highest Phase	Product
Hypertension 567 Sources: http://drdoping.com/instructions/Proroxan/ http://dspace.vnmu.edu.ua/bitstream/handle/123456789/1660/General_Pharmacology%20and%20drugs%20affecting%20mediatory%20processes.pdf?sequence=1	Primary	Approved 8429	Pirroksan Approved Use Proroxan has been used as an antihypertensive and in the treatment of Ménière’s disease, motion sickness, and allergic dermatitis.
Meniere's disease 16 Sources: http://drdoping.com/instructions/Proroxan/ http://medsideen.bitballoon.com/for-the-nervous-syst102/pirroksan2432.html	Primary	Approved 8429	Pirroksan Approved Use Proroxan has been used as an antihypertensive and in the treatment of Ménière’s disease, motion sickness, and allergic dermatitis.
Motion sickness 43 Sources: http://noillen.bitballoon.com/medicine2/pirroksan-instructio1832 http://medsideen.bitballoon.com/for-the-nervous-syst102/pirroksan2432.html	Primary	Approved 8429	Pirroksan Approved Use Proroxan has been used as an antihypertensive and in the treatment of Ménière’s disease, motion sickness, and allergic dermatitis.

PubMed

Title	Date	PubMed
[Adrenergic component in the hepatotropic, carcinogenic effect of diethylnitrosamine].	1977 Apr	15687

Patents

Sample Use Guides

In Vivo Use Guide

Adults: tablets - 20 mg 2-3 times a day; injection - 2-3 ml per day; The maximum daily dose is 90 mg;

Route of Administration: Other

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:00:43 GMT 2023` Edited by `admin` on `Fri Dec 15 17:00:43 GMT 2023`
Record UNII	T5WT3QN49G
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PROROXAN

Official Name

English

1-(1,4-BENZODIOXAN-6-YL)-3-(3-PHENYL-1-PYRROLIDINYL)-1-PROPANONE

Systematic Name

English

1-PROPANONE, 1-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-(3-PHENYL-1-PYRROLIDINYL)-

Systematic Name

English

PROROXAN [MART.]

Common Name

English

proroxan [INN]

Common Name

English

1-PROPANONE, 1-(1,4-BENZODIOXAN-6-YL)-3-(3-PHENYL-1-PYRROLIDINYL)-

Systematic Name

English

Proroxan [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29713